Fbxo45 ELISA Kit for Mouse(Mus musculus) | EIAab.comFbxo45 ELISA Kit for Mouse(Mus musculus)

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Fbxo45 (Gene name),

F-box/SPRY domain-containing protein 1 (Protein name ), FBSP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fbxo45;

Protein name:

F-box/SPRY domain-containing protein 1;

Alternative:

F-box only protein 45(mFbxo45);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein) complex. Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to its ubiquination and degradation (By similarity). Interacts (via SRY domain) with UNC13A; leading to its degradation by the proteasome.

Function:

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Cell junction synapse presynaptic cell membrane

Protein Attributes:

Sequence length:

286

Sequence:

50:

100:

150:

200:

250:

286:

GVAFRGLPKA | CLYPAVSAVY | GNTEVTLVYL | GKPLDG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:268882

SMR:

Q8K3B1

Pfam:

PF00622

UniGene:

Mm.256137

String:

Q8K3B1

Uniprot:

Q8K3B1

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ELISA Kit for Mouse F-box/SPRY domain-containing protein 1

Cat.:

E3813m

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96T

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ELISA Kit for Mouse F-box/SPRY domain-containing protein 1

Cat.:

E3813h

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Packing:

96T

ELISA Kit for Mouse F-box/SPRY domain-containing protein 1

Cat.:

E3813r

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96T

CLIA Kit for Mouse F-box/SPRY domain-containing protein 1

Cat.:

U3813h

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Packing:

96T

CLIA Kit for Mouse F-box/SPRY domain-containing protein 1

Cat.:

U3813m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse F-box/SPRY domain-containing protein 1

Cat.:

U3813r

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96T

Polyclonal Antibody for Mouse F-box/SPRY domain-containing protein 1

Cat.:

P3813Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse F-box/SPRY domain-containing protein 1

Cat.:

P3813Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse F-box/SPRY domain-containing protein 1

Cat.:

P3813Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse F-box/SPRY domain-containing protein 1

Protein for Mouse F-box/SPRY domain-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
strain: FVB/N.
tissue: Brain.
tissue: Mammary gland.
tissue: Olfactory epithelium.
2.

"Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
Saiga T. , Fukuda T. , Matsumoto M. , Tada H. , Okano H.J. , Okano H. , Nakayama K.I.
Mol. Cell. Biol.29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MYCBP2 AND SKP1;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE;MUTAGENESIS OF ARG-42
3.

"Fbxo45, a novel ubiquitin ligase, regulates synaptic activity."
Tada H. , Okano H.J. , Takagi H. , Shibata S. , Yao I. , Matsumoto M. , Saiga T. , Nakayama K.I. , Kashima H. , Takahashi T. , Setou M. , Okano H.
J. Biol. Chem.285:3840-3849(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH UNC13A AND SKP1

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