Protein name:
F-box/SPRY domain-containing protein 1 ;
Alternative:
F-box only protein 45 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein) complex (By similarity). Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to its ubiquination and degradation (By similarity). Interacts (via SRY domain) with UNC13A; leading to its degradation by the proteasome.
Function:
Component of E3 ubiquitin ligase complexes (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.
Subcellular Location:
Cell junction
synapse
postsynaptic cell membrane
Cell junction
synapse
presynaptic cell membrane
Protein Attributes:
50:
LASRALVCKH | WYRCLHGDEN | SEVWRSLCAR | SLEEAMRTDI | LCNLPSYKAK |
100:
VRAFQHAFST | NDCSRNVYIK | KNGFTLHRNP | IAQSTDGART | KIGFSEGRHA |
150:
WEVWWEGPLG | TVAVIGIATK | RAPMQCQGYV | ALLGSDDQSW | GWNLVDNNLL |
200:
HNGEVNGSFP | QCNNAPKYQI | GERIRVILDM | EDKTLAFERG | YEFLGVAFRG |
230:
LPKACLYPAV | SAVYGNTEVT | LVYLGKPLDG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Rat F-box/SPRY domain-containing protein 1
ELISA Kit for Rat F-box/SPRY domain-containing protein 1
ELISA Kit for Rat F-box/SPRY domain-containing protein 1
CLIA Kit for Rat F-box/SPRY domain-containing protein 1
CLIA Kit for Rat F-box/SPRY domain-containing protein 1
CLIA Kit for Rat F-box/SPRY domain-containing protein 1
Polyclonal Antibody for Rat F-box/SPRY domain-containing protein 1
Polyclonal Antibody for Rat F-box/SPRY domain-containing protein 1
Polyclonal Antibody for Rat F-box/SPRY domain-containing protein 1
Monoclonal Antibody for Rat F-box/SPRY domain-containing protein 1
Monoclonal Antibody for Rat F-box/SPRY domain-containing protein 1
Monoclonal Antibody for Rat F-box/SPRY domain-containing protein 1
Protein for Rat F-box/SPRY domain-containing protein 1
Protein for Rat F-box/SPRY domain-containing protein 1
Protein for Rat F-box/SPRY domain-containing protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
"Fbxo45, a novel ubiquitin ligase, regulates synaptic activity."
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J. Biol. Chem.285:3840-3849(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION