FCGR3B ELISA Kit for Human(Homo sapiens) | EIAab.comFCGR3B ELISA Kit for Human(Homo sapiens) | EIAab.com

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FCGR3B (Gene name),

Low affinity immunoglobulin gamma Fc region receptor III-B (Protein name ), FCG3B_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

FCGR3B(CD16B;FCG3;FCGR3;IGFR3);

Protein name:

Low affinity immunoglobulin gamma Fc region receptor III-B;

Alternative:

FcR-10;Fc-gamma RIII-beta(Fc-gamma RIII;Fc-gamma RIIIb;FcRIII;FcRIIIb);IgG Fc receptor III-1;

CD:

CD16b;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Interacts with INPP5D/SHIP1.

Function:

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Subcellular Location:

Cell membrane Lipid-anchor GPI-anchor Secreted Secreted after cleavage.

Protein Attributes:

Sequence length:

233

Sequence:

50:

MWQLLLPTAL | LLLVSAGMRT | EDLPKAVVFL | EPQWYSVLEK | DSVTLKCQGA |

100:

YSPEDNSTQW | FHNESLISSQ | ASSYFIDAAT | VNDSGEYRCQ | TNLSTLSDPV |

150:

QLEVHIGWLL | LQAPRWVFKE | EDPIHLRCHS | WKNTALHKVT | YLQNGKDRKY |

200:

FHHNSDFHIP | KATLKDSGSY | FCRGLVGSKN | VSSETVNITI | TQGLAVSTIS |

233:

SFSPPGYQVS | FCLVMVLLFA | VDTGLYFSVK | TNI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

String:

SMR:

MIM:

STRING:

9606.ENSP00000294800

KEGG:

UniGene:

Uniprot:

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ELISA Kit for Human Low affinity immunoglobulin gamma Fc region receptor III-B

Cat.:

E9986h

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Packing:

96T

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CLIA Kit for Human Low affinity immunoglobulin gamma Fc region receptor III-B

Cat.:

U9986h

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96T

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Polyclonal Antibody for Human Low affinity immunoglobulin gamma Fc region receptor III-B

Cat.:

P9986Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Low affinity immunoglobulin gamma Fc region receptor III-B

Protein for Human Low affinity immunoglobulin gamma Fc region receptor III-B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions."
Ravetch J.V. , Perussia B.
J. Exp. Med.170:481-497(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*02)
2.

"The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein."
Simmons D. , Seed B.
Nature333:568-570(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*02)
tissue: Placenta.
3.

Simmons D. , Seed B.
Nature340:662-662(1989)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Human Fc-gamma-RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG."
Peltz G.A. , Grundy H.O. , Lebo R.V. , Yssel H. , Barsh G.S. , Moore K.W.
Proc. Natl. Acad. Sci. U.S.A.86:1013-1017(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*01)
tissue: Leukocyte.
5.

"A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms."
Scallon B.J. , Scigliano E. , Freedman V.H. , Miedel M.C. , Pan Y.C. , Unkeless J.C. , Kochan J.P.
Proc. Natl. Acad. Sci. U.S.A.86:5079-5083(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles."
Bertrand G. , Duprat E. , Lefranc M.-P. , Marti J. , Coste J.
Tissue Antigens64:119-131(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*02)
tissue: Peripheral blood.
7.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ASN-65
8.

"The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions."
Gessner J.E. , Grussenmeyer T. , Kolanus W. , Schmidt R.E.
J. Biol. Chem.270:1350-1361(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72 (ALLELE FCGR3B*02)
tissue: Placenta.
9.

"The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex."
Sondermann P. , Huber R. , Oosthuizen V. , Jacob U.
Nature406:267-273(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) IN COMPLEX WITH IGG1 FC
10.

"Crystal structure of the extracellular domain of a human Fc gamma RIII."
Zhang Y. , Boesen C.C. , Radaev S. , Brooks A.G. , Fridman W.H. , Sautes-Fridman C. , Sun P.D.
Immunity13:387-395(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 19-192
11.

"Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb."
Bux J. , Stein E.L. , Bierling P. , Fromont P. , Clay M. , Stroncek D. , Santoso S.
Blood89:1027-1034(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SH ASP-78

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