Protein name:
IgG receptor FcRn large subunit p51 (FcRn) ;
Alternative:
Neonatal Fc receptor ;IgG Fc fragment receptor transporter alpha chain ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer.
Function:
Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MGMPLPWALS | LLLVLLPQTW | GSETRPPLMY | HLTAVSNPST | GLPSFWATGW |
100:
LGPQQYLTYN | SLRQEADPCG | AWMWENQVSW | YWEKETTDLK | SKEQLFLEAL |
150:
KTLEKILNGT | YTLQGLLGCE | LASDNSSVPT | AVFALNGEEF | MKFNPRIGNW |
200:
TGEWPETEIV | ANLWMKQPDA | ARKESEFLLN | SCPERLLGHL | ERGRRNLEWK |
250:
EPPSMRLKAR | PGNSGSSVLT | CAAFSFYPPE | LKFRFLRNGL | ASGSGNCSTG |
300:
PNGDGSFHAW | SLLEVKRGDE | HHYQCQVEHE | GLAQPLTVDL | DSSARSSVPV |
350:
VGIVLGLLLV | VVAIAGGVLL | WGRMRSGLPA | PWLSLSGDDS | GDLLPGGNLP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Polyclonal Antibody for Mouse FcRn
Polyclonal Antibody for Mouse FcRn
Polyclonal Antibody for Mouse FcRn
Monoclonal Antibody for Mouse FcRn
Monoclonal Antibody for Mouse FcRn
Monoclonal Antibody for Mouse FcRn
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
strain :
A/J .
strain :
AKR .
strain :
BALB/c .
strain :
C3H .
strain :
DBA/2 .
strain :
P/J .
strain :
TW75 .
tissue :
Small intestine .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
FVB/N .
tissue :
Small intestine .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 167-173;IDENTIFICATION BY MASS SPECTROMETRY
strain :
OF1 .
tissue :
Hippocampus .