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Index > Protein center > Fcgrt(Gene name) > Rat
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  • Fcgrt (Gene name),
  • IgG receptor FcRn large subunit p51 (Protein name ),  FCGRN_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Fcgrt(Fcrn);
    Protein name:
    IgG receptor FcRn large subunit p51(FcRn);
    Alternative:
    Neonatal Fc receptor;IgG Fc fragment receptor transporter alpha chain;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MCH class I-like heterodimer.
    Function:
    Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    366
    Sequence:
    50:
    MGMSQPGVLL | SLLLVLLPQT | WGAEPRLPLM | YHLAAVSDLS | TGLPSFWATG | 
    100:
    WLGAQQYLTY | NNLRQEADPC | GAWIWENQVS | WYWEKETTDL | KSKEQLFLEA | 
    150:
    IRTLENQING | TFTLQGLLGC | ELAPDNSSLP | TAVFALNGEE | FMRFNPRTGN | 
    200:
    WSGEWPETDI | VGNLWMKQPE | AARKESEFLL | TSCPERLLGH | LERGRQNLEW | 
    250:
    KEPPSMRLKA | RPGNSGSSVL | TCAAFSFYPP | ELKFRFLRNG | LASGSGNCST | 
    300:
    GPNGDGSFHA | WSLLEVKRGD | EHHYQCQVEH | EGLAQPLTVD | LDSPARSSVP | 
    350:
    VVGIILGLLL | VVVAIAGGVL | LWNRMRSGLP | APWLSLSGDD | SGDLLPGGNL | 
    366:
    PPEAEPQGVN | AFPATS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat FcRn
    Cat.:
    E13790h
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    Packing:
    96T
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    ELISA Kit for Rat FcRn
    Cat.:
    E13790r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat FcRn
    Cat.:
    E13790m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Rat FcRn
    Cat.:
    U13790h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat FcRn
    MSDS:
    Please sign in first.
    CLIA Kit for Rat FcRn
    Cat.:
    U13790m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat FcRn
    Polyclonal Antibody for Rat FcRn
    Polyclonal Antibody for Rat FcRn
    Monoclonal Antibody for Rat FcRn
    Monoclonal Antibody for Rat FcRn
    Monoclonal Antibody for Rat FcRn
    Protein for Rat FcRn
    Protein for Rat FcRn
    Protein for Rat FcRn

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "An Fc receptor structurally related to MHC class I antigens."
      Simister N.E. , Mostov K.E.
      Nature337:184-187(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      strain: Wistar.
    2. 2.
      "Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog."
      Simister N.E. , Mostov K.E.
      Cold Spring Harb. Symp. Quant. Biol.54:571-580(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Epithelium.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    4. 4.
      "Crystal structure of the complex of rat neonatal Fc receptor with Fc."
      Burmeister W.P. , Huber A.H. , Bjorkman P.J.
      Nature372:379-383(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    5. 5.
      "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor."
      Vaughn D.E. , Bjorkman P.J.
      Structure6:63-73(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
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