FHIT ELISA Kit for Human(Homo sapiens) | EIAab.comFHIT ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FHIT(Gene name) > Human

FHIT (Gene name),

Bis(5'-adenosyl)-triphosphatase (Protein name ), FHIT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

FHIT;

Protein name:

Bis(5'-adenosyl)-triphosphatase;

Alternative:

Diadenosine 5',5'''-P1,P3-triphosphate hydrolase;AP3A hydrolase(AP3Aase);Fragile histidine triad protein;Dinucleosidetriphosphatase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

147

Sequence:

50:

100:

147:

PRKAGDFHRN | DSIYEELQKH | DKEDFPASWR | SEEEMAAEAA | ALRVYFQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

601153

SMR:

P49789

KEGG:

hsa:2272

UniGene:

Hs.655995

String:

P49789

Pfam:

PF01230

STRING:

9606.ENSP00000342087

Uniprot:

P49789

FOR

ELISA Kit for Human Bis(5'-adenosyl)-triphosphatase

CLIA Kit for Human Bis(5'-adenosyl)-triphosphatase

Polyclonal Antibody for Human Bis(5'-adenosyl)-triphosphatase

Monoclonal Antibody for Human Bis(5'-adenosyl)-triphosphatase

Protein for Human Bis(5'-adenosyl)-triphosphatase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers."
Ohta M. , Inoue H. , Cotticelli M.G. , Kastury K. , Baffa R. , Palazzo J. , Siprashvili Z. , Mori M. , McCue P. , Druck T. , Croce C.M. , Huebner K.
Cell84:587-597(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.

"Structure and expression of the human FHIT gene in normal and tumor cells."
Druck T. , Hadaczek P. , Fu T.B. , Ohta M. , Siprashvili Z. , Baffa R. , Negrini M. , Kastury K. , Veronese M.L. , Rosen D. , Rothstein J. , McCue P. , Cotticelli M.G. , Inoue H. , Croce C.M. , Huebner K.
Cancer Res.57:504-512(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
Corominas R. , Yang X. , Lin G.N. , Kang S. , Shen Y. , Ghamsari L. , Broly M. , Rodriguez M. , Tam S. , Wanamaker S.A. , Fan C. , Yi S. , Tasan M. , Lemmens I. , Kuang X. , Zhao N. , Malhotra D. , Michaelson J.J. , more...
Nat. Commun.5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Mutational analysis of FHIT gene."
Naqvi S.R.A. , Malik A. , Kukreti H. , Chaudhary A. , Anand R. , Deo S.S. , Shukla N.K. , Husain S.A. , Pasha S.T.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-146
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
8.

"Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5''-P1,P3-triphosphate hydrolase."
Barnes L.D. , Garrison P.N. , Siprashvili Z. , Guranowski A. , Robinson A.K. , Ingram S.W. , Croce C.M. , Ohta M. , Huebner K.
Biochemistry35:11529-11535(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF HIS-35; HIS-94; HIS-96 AND HIS-98
9.

"The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8."
Gemmill R.M. , West J.D. , Boldog F. , Tanaka N. , Robinson L.J. , Smith D.I. , Li F. , Drabkin H.A.
Proc. Natl. Acad. Sci. U.S.A.95:9572-9577(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH RNF139
10.

"Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9."
Shi Y. , Zou M. , Farid N.R. , Paterson M.C.
Biochem. J.352:443-448(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2I
11.

"Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding."
Trapasso F. , Krakowiak A. , Cesari R. , Arkles J. , Yendamuri S. , Ishii H. , Vecchione A. , Kuroki T. , Bieganowski P. , Pace H.C. , Huebner K. , Croce C.M. , Brenner C.
Proc. Natl. Acad. Sci. U.S.A.100:1592-1597(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF ILE-10; LEU-25 AND HIS-96
12.

"The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit."
Huang K. , Arabshahi A. , Wei Y. , Frey P.A.
Biochemistry43:7637-7642(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;CATALYTIC ACTIVITY;MUTAGENESIS OF HIS-96
13.

"Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells."
Nishizaki M. , Sasaki J. , Fang B. , Atkinson E.N. , Minna J.D. , Roth J.A. , Ji L.
Cancer Res.64:5745-5752(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MDM2
14.

"Fhit is a physiological target of the protein kinase Src."
Pekarsky Y. , Garrison P.N. , Palamarchuk A. , Zanesi N. , Aqeilan R.I. , Huebner K. , Barnes L.D. , Croce C.M.
Proc. Natl. Acad. Sci. U.S.A.101:3775-3779(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY SRC;SUBUNIT;SUBCELLULAR LOCATION;MASS SPECTROMETRY;DISEASE;PHOSPHORYLATION AT TYR-114 AND TYR-145;MUTAGENESIS OF TYR-114 AND TYR-145
15.

"Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential."
Semba S. , Trapasso F. , Fabbri M. , McCorkell K.A. , Volinia S. , Druck T. , Iliopoulos D. , Pekarsky Y. , Ishii H. , Garrison P.N. , Barnes L.D. , Croce C.M. , Huebner K.
Oncogene25:2860-2872(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-114;FUNCTION
16.

"The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity."
Weiske J. , Albring K.F. , Huber O.
Proc. Natl. Acad. Sci. U.S.A.104:20344-20349(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1;IDENTIFICATION IN A COMPLEX WITH CTNNB1 AND LEF1;FUNCTION
17.

"Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis."
Rimessi A. , Marchi S. , Fotino C. , Romagnoli A. , Huebner K. , Croce C.M. , Pinton P. , Rizzuto R.
Proc. Natl. Acad. Sci. U.S.A.106:12753-12758(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION IN APOPTOSIS
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family."
Lima C.D. , D'Amico K.L. , Naday I. , Rosenbaum G. , Westbrook E.M. , Hendrickson W.A.
Structure5:763-774(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS)
20.

"Structure-based analysis of catalysis and substrate definition in the HIT protein family."
Lima C.D. , Klein M.G. , Hendrickson W.A.
Science278:286-290(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEXES WITH SUBSTRATES;CATALYTIC ACTIVITY;FUNCTION;SUBUNIT;ACTIVE SITE;ABSENCE OF METAL COFACTOR
21.

"Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit."
Pace H.C. , Garrison P.N. , Robinson A.K. , Barnes L.D. , Draganescu A. , Roesler A. , Blackburn G.M. , Siprashvili Z. , Croce C.M. , Huebner K. , Brenner C.
Proc. Natl. Acad. Sci. U.S.A.95:5484-5489(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEXES WITH SUBSTRATE ANALOGS;SUBUNIT;CATALYTIC ACTIVITY;COFACTOR;MUTAGENESIS OF HIS-96

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