Gene name:
FIP1L1 (FIP1;RHE) ;
Protein name:
Pre-mRNA 3'-end-processing factor FIP1 (hFip1) ;
Alternative:
Factor interacting with PAP ;FIP1-like 1 protein ;Rearranged in hypereosinophilia ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4, CSTF2, CSTF3 and PAPOLA.
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSAGEVERLV | SELSGGTGGD | EEEEWLYGGP | WDVHVHSDLA | KDLDENEVER |
100:
PEEENASANP | PSGIEDETAE | NGVPKPKVTE | TEDDSDSDSD | DDEDDVHVTI |
150:
GDIKTGAPQY | GSYGTAPVNL | NIKTGGRVYG | TTGTKVKGVD | LDAPGSINGV |
200:
PLLEVDLDSF | EDKPWRKPGA | DLSDYFNYGF | NEDTWKAYCE | KQKRIRMGLE |
250:
VIPVTSTTNK | ITAEDCTMEV | TPGAEIQDGR | FNLFKVQQGR | TGNSEKETAL |
300:
PSTKAEFTSP | PSLFKTGLPP | SRNSTSSQSQ | TSTASRKANS | SVGKWQDRYG |
350:
RAESPDLRRL | PGAIDVIGQT | ITISRVEGRR | RANENSNIQV | LSERSATEVD |
400:
NNFSKPPPFF | PPGAPPTHLP | PPPFLPPPPT | VSTAPPLIPP | PGFPPPPGAP |
450:
PPSLIPTIES | GHSSGYDSRS | ARAFPYGNVA | FPHLPGSAPS | WPSLVDTSKQ |
500:
WDYYARREKD | RDRERDRDRE | RDRDRDRERE | RTRERERERD | HSPTPSVFNS |
550:
DEERYRYREY | AERGYERHRA | SREKEERHRE | RRHREKEETR | HKSSRSNSRR |
594:
RHESEEGDSH | RRHKHKKSKR | SKEGKEAGSE | PAPEQESTEA | TPAE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human hFip1
ELISA Kit for Human hFip1
ELISA Kit for Human hFip1
Polyclonal Antibody for Human hFip1
Polyclonal Antibody for Human hFip1
Polyclonal Antibody for Human hFip1
Monoclonal Antibody for Human hFip1
Monoclonal Antibody for Human hFip1
Monoclonal Antibody for Human hFip1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION IN PRE-MRNA 3'-END PROCESSING;IDENTIFICATION IN THE CPSF COMPLEX;IDENTIFICATION IN A COMPLEX WITH CPSF1 AND PAPOLA;INTERACTION WITH CPSF1; CPSF4; CSTF2; CSTF3 AND PAPOLA;RNA-BINDING;IDENTIFICATION BY MASS SPECTROMETRY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Uterus .
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Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue :
Hippocampus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
tissue :
Brain .
tissue :
Eye .
tissue :
Placenta .
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-339;DISEASE;IDENTIFICATION BY MASS SPECTROMETRY OF THE FIP1L1-PDGFRA FUSION PROTEIN
tissue :
Eosinophil .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RNA-BINDING
9.
"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome."
Cools J.
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N. Engl. J. Med.348:1201-1214(2003)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISEASE
10.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-87; SER-89; SER-259; SER-492; SER-496 AND SER-500;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-87; SER-89; SER-492; THR-494; SER-496 AND SER-500;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-294;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
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Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; SER-304; SER-492 AND SER-554;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-87; SER-259; SER-304; SER-492 AND SER-496;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]