FKBP4 ELISA Kit for Human(Homo sapiens) | EIAab.comFKBP4 ELISA Kit for Human(Homo sapiens)

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FKBP4 (Gene name),

Peptidyl-prolyl cis-trans isomerase FKBP4 (Protein name ), FKBP4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FKBP4(FKBP52);

Protein name:

Peptidyl-prolyl cis-trans isomerase FKBP4(PPIase FKBP4);

Alternative:

52 kDa FK506-binding protein(52 kDa FKBP;FKBP-52);51 kDa FK506-binding protein(FKBP51);FK506-binding protein 4(FKBP-4);59 kDa immunophilin(p59);HSP-binding immunophilin(HBI);FKBP59;Rotamase;Immunophilin FKBP52;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with HSF1 in the HSP90 complex. Associates with tubulin (By similarity). Interacts with MAPT/TAU (By similarity). Interacts with NR3C1 and dynein (By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction.

Function:

Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

Subcellular Location:

Cytoplasm cytosol Nucleus Cytoplasm cytoskeleton

Protein Attributes:

Sequence length:

459

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

459:

SQSQVETEA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00254

SMR:

Q02790

KEGG:

hsa:2288

MIM:

600611

UniGene:

Hs.524183

String:

Q02790

STRING:

9606.ENSP00000001008

Uniprot:

Q02790

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ELISA Kit for Human PPIase FKBP4

Cat.:

E11170h

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96T

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ELISA Kit for Human PPIase FKBP4

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ELISA Kit for Human PPIase FKBP4

Cat.:

E11170m

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Packing:

96T

ELISA Kit for Human PPIase FKBP4

Cat.:

E11170r

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96T

ELISA Kit for Human PPIase FKBP4

Cat.:

E11170b

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Packing:

96T

CLIA Kit for Human PPIase FKBP4

Cat.:

U11170r

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Packing:

96T

CLIA Kit for Human PPIase FKBP4

Cat.:

U11170m

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MSDS:

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Packing:

96T

CLIA Kit for Human PPIase FKBP4

MSDS:

Please sign in first.

CLIA Kit for Human PPIase FKBP4

Cat.:

U11170b

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Packing:

96T

CLIA Kit for Human PPIase FKBP4

Cat.:

U11170h

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Manual:

Looking for manual.

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Packing:

96T

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Polyclonal Antibody for Human PPIase FKBP4

Cat.:

P11170Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human PPIase FKBP4

Cat.:

P11170Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human PPIase FKBP4

Cat.:

P11170Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human PPIase FKBP4

Protein for Human PPIase FKBP4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes."
Peattie D.A. , Harding M.W. , Fleming M.A. , Decenzo M.T. , Lippke J.A. , Livingston D.J. , Benasutti M.
Proc. Natl. Acad. Sci. U.S.A.89:10974-10978(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;ENZYME REGULATION;TISSUE SPECIFICITY
tissue: Placenta.
2.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
tissue: Uterus.
5.

Bienvenut W.V. , Lourenco F. , Olson M.F.
Submitted (2010-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-28; 40-73; 75-121; 139-152; 158-179; 187-206; 211-250; 257-274; 277-313; 319-354; 359-399; 409-426 AND 446-459;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT MET-1 AND THR-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Mammary carcinoma.
tissue: Ovarian carcinoma.
6.

"Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex."
Tai P.-K.K. , Albers M.W. , Chang H. , Faber L.E. , Schreiber S.L.
Science256:1315-1318(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-25;SUBUNIT;FUNCTION
tissue: Thymus.
7.

"The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins."
Sanchez E.R. , Faber L.E. , Henzel W.J. , Pratt W.B.
Biochemistry29:5145-5152(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION
tissue: Lymphocyte.
8.

"The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13."
Yem A.W. , Tomasselli A.G. , Heinrikson R.L. , Zurcher-Neely H. , Ruff V.A. , Johnson R.A. , Deibel M.R. Jr.
J. Biol. Chem.267:2868-2871(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-18
tissue: T-cell.
9.

"Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex."
Wiederrecht G. , Hung S. , Chan H.K. , Marcy A. , Martin M. , Calaycay J. , Boulton D. , Sigal N. , Kincaid R.L. , Siekierka J.J.
J. Biol. Chem.267:21753-21760(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 16-32;SUBUNIT
10.

"The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52."
Bruner K.L. , Derfoul A. , Robertson N.M. , Guerriero G. , Fernandes-Alnemri T. , Alnemri E.S. , Litwack G.
Recept. Signal Transduct.7:85-98(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TERNARY COMPLEX WITH HSP90; HSP70 AND NR3C2;DISSOCIATION UPON ALDOSTERONE BINDING
11.

"Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex."
Guo Y. , Guettouche T. , Fenna M. , Boellmann F. , Pratt W.B. , Toft D.O. , Smith D.F. , Voellmy R.
J. Biol. Chem.276:45791-45799(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HSF1
12.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451 AND SER-453;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening."
Shim S. , Yuan J.P. , Kim J.Y. , Zeng W. , Huang G. , Milshteyn A. , Kern D. , Muallem S. , Ming G.L. , Worley P.F.
Neuron64:471-483(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRPC1;FUNCTION;MUTAGENESIS OF 67-PHE-ASP-68
17.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-282;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats."
Shimamoto S. , Kubota Y. , Tokumitsu H. , Kobayashi R.
FEBS Lett.584:1119-1125(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S100A1; S100A2 AND S100A6
19.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress."
Gallo L.I. , Lagadari M. , Piwien-Pilipuk G. , Galigniana M.D.
J. Biol. Chem.286:30152-30160(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;INTERACTION WITH GLUCOCORTICOID RECEPTOR
22.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451 AND SER-453;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Structure of the N-terminal domain of human FKBP52."
Li P. , Ding Y. , Wu B. , Shu C. , Shen B. , Rao Z.
Acta Crystallogr. D59:16-22(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 2-139
24.

"3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex."
Wu B. , Li P. , Liu Y. , Lou Z. , Ding Y. , Shu C. , Ye S. , Bartlam M. , Shen B. , Rao Z.
Proc. Natl. Acad. Sci. U.S.A.101:8348-8353(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2-458 IN COMPLEX WITH HSP90;SUBUNIT

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