FKBP4 ELISA Kit for Rabbit(Oryctolagus cuniculus) | EIAab.comFKBP4 ELISA Kit for Rabbit(Oryctolagus cuniculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > FKBP4(Gene name) > Rabbit

FKBP4 (Gene name),

Peptidyl-prolyl cis-trans isomerase FKBP4 (Protein name ), FKBP4_RABIT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

FKBP4(P59);

Protein name:

Peptidyl-prolyl cis-trans isomerase FKBP4(PPIase FKBP4);

Alternative:

59 kDa immunophilin(p59);52 kDa FK506-binding protein(52 kDa FKBP;FKBP-52);FKBP59;FK506-binding protein 4(FKBP-4);Immunophilin FKBP52;HSP-binding immunophilin(HBI);Rotamase;

Organism:

Rabbit (Oryctolagus cuniculus).

General Annotation

Sub Unit:

Homodimer (By similarity). Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH) (By similarity). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex (By similarity). Associates with tubulin (By similarity). Interacts with MAPT/TAU; the interaction is enhanced for phosphorylated MAPT/TAU (By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent (By similarity). Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction.

Function:

Immunophilin protein with PPIase and co-chaperone activities. Component of unliganded steroid receptors heterocomplexes thought interaction with heat-shock protein 90 (HSP90) (By similarity). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

Subcellular Location:

Cytoplasm cytosol Nucleus Cytoplasm cytoskeleton

Protein Attributes:

Sequence length:

458

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

458:

QSQVETEA

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Ocu.1944

String:

P27124

SMR:

P27124

Pfam:

PF00254

STRING:

9986.ENSOCUP00000012554

Uniprot:

P27124

FOR

ELISA Kit for Rabbit PPIase FKBP4

Cat.:

E11170h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rabbit PPIase FKBP4

MSDS:

Please sign in first.

ELISA Kit for Rabbit PPIase FKBP4

Cat.:

E11170m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rabbit PPIase FKBP4

Cat.:

E11170r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rabbit PPIase FKBP4

Cat.:

E11170b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rabbit PPIase FKBP4

Cat.:

U11170r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rabbit PPIase FKBP4

Cat.:

U11170m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rabbit PPIase FKBP4

MSDS:

Please sign in first.

CLIA Kit for Rabbit PPIase FKBP4

Cat.:

U11170b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rabbit PPIase FKBP4

Cat.:

U11170h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Rabbit PPIase FKBP4

Cat.:

P11170Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rabbit PPIase FKBP4

Cat.:

P11170Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rabbit PPIase FKBP4

Cat.:

P11170Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Rabbit PPIase FKBP4

Protein for Rabbit PPIase FKBP4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody."
Lebeau M.-C. , Massol N. , Herrick J. , Faber L.E. , Renoir J.-M. , Radanyi C. , Baulieu E.-E.
J. Biol. Chem.267:4281-4284(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit."
Deshpande K.L. , Seubert P.H. , Tillman D.M. , Farkas W.R. , Katze J.R.
Arch. Biochem. Biophys.326:1-7(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-26
strain: New Zealand white.
tissue: Liver.
3.

"An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein."
Callebaut I. , Renoir J.-M. , Lebeau M.-C. , Massol N. , Burny A. , Baulieu E.-E. , Mornon J.-P.
Proc. Natl. Acad. Sci. U.S.A.89:6270-6274(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAINS
4.

"Overexpression of p59-HBI (FKBP59), full length and domains, and characterization of PPlase activity."
Chambraud B. , Rouviere-Fourmy N. , Radanyi C. , Hsiao K. , Peattie D.A. , Livingston D.J. , Baulieu E.E.
Biochem. Biophys. Res. Commun.196:160-166(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PPIASE ACTIVITY
5.

"Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin."
Silverstein A.M. , Galigniana M.D. , Chen M.S. , Owens-Grillo J.K. , Chinkers M. , Pratt W.B.
J. Biol. Chem.272:16224-16230(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH NR3C1 AND HSP90AA1
6.

"Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52."
Miyata Y. , Chambraud B. , Radanyi C. , Leclerc J. , Lebeau M.-C. , Renoir J.-M. , Shirai R. , Catelli M.-G. , Yahara I. , Baulieu E.-E.
Proc. Natl. Acad. Sci. U.S.A.94:14500-14505(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CK2
7.

"Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein."
Silverstein A.M. , Galigniana M.D. , Kanelakis K.C. , Radanyi C. , Renoir J.-M. , Pratt W.B.
J. Biol. Chem.274:36980-36986(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR3C1; DYNEIN AND HSP90
8.

"Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-CoA alpha-hydroxylase is a new FKBP-associated protein."
Chambraud B. , Radanyi C. , Camonis J.H. , Rajkowski K. , Schumacher M. , Baulieu E.-E.
Proc. Natl. Acad. Sci. U.S.A.96:2104-2109(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHYH
9.

"Localization of the chaperone domain of FKBP52."
Pirkl F. , Fischer E. , Modrow S. , Buchner J.
J. Biol. Chem.276:37034-37041(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A CO-CHAPERONE;DOMAINS
10.

"Three-dimensional structure of the immunophilin-like domain of FKBP59 in solution."
Craescu C.T. , Rouviere N. , Popescu A. , Cerpolini E. , Lebeau M.-C. , Baulieu E.-E. , Mispelter J.
Biochemistry35:11045-11052(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-149

Product Feedback Wall

* Email:
*Comments: