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Index > Protein center > FLVCR1(Gene name) > Human
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  • FLVCR1 (Gene name),
  • Feline leukemia virus subgroup C receptor-related protein 1 (Protein name ),  FLVC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FLVCR1(FLVCR);
    Protein name:
    Feline leukemia virus subgroup C receptor-related protein 1(Feline leukemia virus subgroup C receptor;hFLVCR);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with HPX.
    Function:
    Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    555
    Sequence:
    50:
    MARPDDEEGA | AVAPGHPLAK | GYLPLPRGAP | VGKESVELQN | GPKAGTFPVN | 
    100:
    GAPRDSLAAA | SGVLGGPQTP | LAPEEETQAR | LLPAGAGAET | PGAESSPLPL | 
    150:
    TALSPRRFVV | LLIFSLYSLV | NAFQWIQYSI | ISNVFEGFYG | VTLLHIDWLS | 
    200:
    MVYMLAYVPL | IFPATWLLDT | RGLRLTALLG | SGLNCLGAWI | KCGSVQQHLF | 
    250:
    WVTMLGQCLC | SVAQVFILGL | PSRIASVWFG | PKEVSTACAT | AVLGNQLGTA | 
    300:
    VGFLLPPVLV | PNTQNDTNLL | ACNISTMFYG | TSAVATLLFI | LTAIAFKEKP | 
    350:
    RYPPSQAQAA | LQDSPPEEYS | YKKSIRNLFK | NIPFVLLLIT | YGIMTGAFYS | 
    400:
    VSTLLNQMIL | TYYEGEEVNA | GRIGLTLVVA | GMVGSILCGL | WLDYTKTYKQ | 
    450:
    TTLIVYILSF | IGMVIFTFTL | DLRYIIIVFV | TGGVLGFFMT | GYLPLGFEFA | 
    500:
    VEITYPESEG | TSSGLLNASA | QIFGILFTLA | QGKLTSDYGP | KAGNIFLCVW | 
    550:
    MFIGIILTAL | IKSDLRRHNI | NIGITNVDVK | AIPADSPTDQ | EPKTVMLSKQ | 
    555:
    SESAI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Feline leukemia virus subgroup C receptor
    ELISA Kit for Human Feline leukemia virus subgroup C receptor
    CLIA Kit for Human Feline leukemia virus subgroup C receptor
    CLIA Kit for Human Feline leukemia virus subgroup C receptor
    Polyclonal Antibody for Human Feline leukemia virus subgroup C receptor
    Polyclonal Antibody for Human Feline leukemia virus subgroup C receptor
    Monoclonal Antibody for Human Feline leukemia virus subgroup C receptor
    Monoclonal Antibody for Human Feline leukemia virus subgroup C receptor
    Protein for Human Feline leukemia virus subgroup C receptor
    Protein for Human Feline leukemia virus subgroup C receptor

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily."
      Tailor C.S. , Willett B.J. , Kabat D.
      J. Virol.73:6500-6505(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;CHARACTERIZATION OF FELV-C RECEPTOR FUNCTION
      tissue: Lymphocyte.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2006-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS PRO-52 AND MET-544
      tissue: Duodenum.
    6. 6.
      "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus."
      Lipovich L. , Hughes A.L. , King M.-C. , Abkowitz J.L. , Quigley J.G.
      Gene286:203-213(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
    7. 7.
      "Identification of a human heme exporter that is essential for erythropoiesis."
      Quigley J.G. , Yang Z. , Worthington M.T. , Phillips J.D. , Sabo K.M. , Sabath D.E. , Berg C.L. , Sassa S. , Wood B.L. , Abkowitz J.L.
      Cell118:757-766(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
    8. 8.
      "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1."
      Brown J.K. , Fung C. , Tailor C.S.
      J. Virol.80:1742-1751(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;GLYCOSYLATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin."
      Yang Z. , Philips J.D. , Doty R.T. , Giraudi P. , Ostrow J.D. , Tiribelli C. , Smith A. , Abkowitz J.L.
      J. Biol. Chem.285:28874-28882(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HPX
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2);FUNCTION (ISOFORM 2);SUBCELLULAR LOCATION (ISOFORM 2)
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCARP ASP-121; ARG-192 AND THR-241
    17. 17.
      "Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1."
      Ishiura H. , Fukuda Y. , Mitsui J. , Nakahara Y. , Ahsan B. , Takahashi Y. , Ichikawa Y. , Goto J. , Sakai T. , Tsuji S.
      Neurogenetics12:117-121(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PCARP ARG-493
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