Gene name:
Foxo3 (Fkhr2;Foxo3a) ;
Protein name:
Forkhead box protein O3 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1 (By similarity). Interacts with DDIT3/CHOP.
Function:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Subcellular Location:
Cytoplasm
Cytosol
Nucleus
Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Protein Attributes:
50:
MAEAPASPVP | LSPLEVELDP | EFEPQSRPRS | CTWPLQRPEL | QASPAKPSGE |
100:
TAADSMIPEE | DDDEDDEDGG | GRASSAMVIG | GGVSSTLGSG | LLLEDSAMLL |
150:
APGGQDLGSG | PASAAGALSG | GTPTQLQPQQ | PLPQPQPGAA | GGSGQPRKCS |
200:
SRRNAWGNLS | YADLITRAIE | SSPDKRLTLS | QIYEWMVRCV | PYFKDKGDSN |
250:
SSAGWKNSIR | HNLSLHSRFM | RVQNEGTGKS | SWWIINPDGG | KSGKAPRRRA |
300:
VSMDNSNKYT | KSRGRAAKKK | AALQAAPESA | DDSPSQLSKW | PGSPTSRSSD |
350:
ELDAWTDFRS | RTNSNASTVS | GRLSPILAST | ELDDVQDDDG | PLSPMLYSSS |
400:
ASLSPSVSKP | CTVELPRLTD | MAGTMNLNDG | LAENLMDDLL | DNIALPPSQP |
450:
SPPGGLMQRG | SSFPYTAKSS | GLGSPTGSFN | STVFGPSSLN | SLRQSPMQTI |
500:
QENRPATFSS | VSHYGNQTLQ | DLLASDSLSH | SDVMMTQSDP | LMSQASTAVS |
550:
AQNARRNVML | RNDPMMSFAA | QPTQGSLVNQ | NLLHHQHQTQ | GALGGSRALS |
600:
NSVSNMGLSD | SSSLGSAKHQ | QQSPASQSMQ | TLSDSLSGSS | LYSASANLPV |
650:
MGHDKFPSDL | DLDMFNGSLE | CDMESIIRSE | LMDADGLDFN | FDSLISTQNV |
672:
VGLNVGNFTG | AKQASSQSWV | PG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Forkhead box protein O3
ELISA Kit for Mouse Forkhead box protein O3
CLIA Kit for Mouse Forkhead box protein O3
CLIA Kit for Mouse Forkhead box protein O3
Polyclonal Antibody for Mouse Forkhead box protein O3
Polyclonal Antibody for Mouse Forkhead box protein O3
Monoclonal Antibody for Mouse Forkhead box protein O3
Monoclonal Antibody for Mouse Forkhead box protein O3
Protein for Mouse Forkhead box protein O3
Protein for Mouse Forkhead box protein O3
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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C57BL/6J .
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Cerebellum .
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-241;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .