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Index > Protein center > Foxo3(Gene name) > Mouse
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  • Foxo3 (Gene name),
  • Forkhead box protein O3 (Protein name ),  FOXO3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Foxo3(Fkhr2;Foxo3a);
    Protein name:
    Forkhead box protein O3;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1 (By similarity). Interacts with DDIT3/CHOP.
    Function:
    Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
    Subcellular Location:
    Cytoplasm Cytosol Nucleus Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
    Protein Attributes:
    Sequence length:
    672
    Sequence:
    50:
    MAEAPASPVP | LSPLEVELDP | EFEPQSRPRS | CTWPLQRPEL | QASPAKPSGE | 
    100:
    TAADSMIPEE | DDDEDDEDGG | GRASSAMVIG | GGVSSTLGSG | LLLEDSAMLL | 
    150:
    APGGQDLGSG | PASAAGALSG | GTPTQLQPQQ | PLPQPQPGAA | GGSGQPRKCS | 
    200:
    SRRNAWGNLS | YADLITRAIE | SSPDKRLTLS | QIYEWMVRCV | PYFKDKGDSN | 
    250:
    SSAGWKNSIR | HNLSLHSRFM | RVQNEGTGKS | SWWIINPDGG | KSGKAPRRRA | 
    300:
    VSMDNSNKYT | KSRGRAAKKK | AALQAAPESA | DDSPSQLSKW | PGSPTSRSSD | 
    350:
    ELDAWTDFRS | RTNSNASTVS | GRLSPILAST | ELDDVQDDDG | PLSPMLYSSS | 
    400:
    ASLSPSVSKP | CTVELPRLTD | MAGTMNLNDG | LAENLMDDLL | DNIALPPSQP | 
    450:
    SPPGGLMQRG | SSFPYTAKSS | GLGSPTGSFN | STVFGPSSLN | SLRQSPMQTI | 
    500:
    QENRPATFSS | VSHYGNQTLQ | DLLASDSLSH | SDVMMTQSDP | LMSQASTAVS | 
    550:
    AQNARRNVML | RNDPMMSFAA | QPTQGSLVNQ | NLLHHQHQTQ | GALGGSRALS | 
    600:
    NSVSNMGLSD | SSSLGSAKHQ | QQSPASQSMQ | TLSDSLSGSS | LYSASANLPV | 
    650:
    MGHDKFPSDL | DLDMFNGSLE | CDMESIIRSE | LMDADGLDFN | FDSLISTQNV | 
    672:
    VGLNVGNFTG | AKQASSQSWV | PG
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Forkhead box protein O3
    Cat.:
    E0762h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Forkhead box protein O3
    Cat.:
    E0762m
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Mouse Forkhead box protein O3
    Cat.:
    U0762h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Forkhead box protein O3
    Cat.:
    U0762m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Forkhead box protein O3
    Cat.:
    P0762Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Forkhead box protein O3
    Cat.:
    P0762Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Forkhead box protein O3
    Monoclonal Antibody for Mouse Forkhead box protein O3
    Protein for Mouse Forkhead box protein O3
    Protein for Mouse Forkhead box protein O3

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse."
      Biggs W.H. III , Cavenee W.K. , Arden K.C.
      Mamm. Genome12:416-425(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Cerebellum.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-255
    6. 6.
      "SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction."
      Wang F. , Nguyen M. , Qin F.X. , Tong Q.
      Aging Cell6:505-514(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;DEACETYLATION BY SIRT2;INTERACTION WITH SIRT2
    7. 7.
      "Novel repressor regulates insulin sensitivity through interaction with Foxo1."
      Nakae J. , Cao Y. , Hakuno F. , Takemori H. , Kawano Y. , Sekioka R. , Abe T. , Kiyonari H. , Tanaka T. , Sakai J. , Takahashi S. , Itoh H.
      EMBO J.31:2275-2295(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-241;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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