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Index > Protein center > Fxn(Gene name) > Rat
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  • Fxn (Gene name),
  • Frataxin, mitochondrial (Protein name ),  FRDA_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fxn;
    Protein name:
    Frataxin, mitochondrial(Fxn);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Monomer (probable predominant form). Oligomer. Interacts with LYRM4 AND HSPA9. Interacts with ACO1. Interacts with ISCU. Interacts with FECH; one iron-bound FXN monomer seems to interact with a FECH homodimer. Interacts with SDHA and SDHB (By similarity). Interacts with ACO2; the interation is dependent on citrate.
    Function:
    Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1.
    Subcellular Location:
    Cytoplasm Mitochondrion
    Protein Attributes:
    Sequence length:
    208
    Sequence:
    50:
    MWTFGRRAAA | GLLPRTASRA | SAWVRNPRGR | ERIGTCGRRG | LHVTANADAI | 
    100:
    RHSHLNLHYL | GQILNIKKQS | VCVVHLRNSG | TLGNPSSLDE | TAYERLAEET | 
    150:
    LDALAEFFED | LADKPYTLKD | YDVSFGDGVL | TIKLGGDLGT | YVINKQTPLL | 
    200:
    YLWFSGPCSG | PKRYDWTGKN | WVYSHDGVSL | HELLARELTE | ALNTKLDLSS | 
    208:
    LAYSGKGT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Fxn
    Cat.:
    E15247r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Fxn
    Cat.:
    E15247h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Fxn
    Cat.:
    E15247b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Fxn
    Cat.:
    E15247m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Fxn
    Cat.:
    U15247m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Fxn
    Cat.:
    U15247h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Fxn
    Cat.:
    U15247r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Fxn
    Cat.:
    U15247b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Fxn
    Cat.:
    P15247Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Fxn
    Cat.:
    P15247Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Fxn
    Polyclonal Antibody for Rat Fxn
    Cat.:
    P15247Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Fxn
    Monoclonal Antibody for Rat Fxn
    Monoclonal Antibody for Rat Fxn
    Monoclonal Antibody for Rat Fxn
    Protein for Rat Fxn
    Protein for Rat Fxn
    Protein for Rat Fxn
    Protein for Rat Fxn

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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity."
      Bulteau A.L. , O'Neill H.A. , Kennedy M.C. , Ikeda-Saito M. , Isaya G. , Szweda L.I.
      Science305:242-245(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS IRON CHAPERONE;INTERACTION WITH ACO2
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