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Index > Protein center > FTO(Gene name) > Human
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  • FTO (Gene name),
  • Alpha-ketoglutarate-dependent dioxygenase FTO (Protein name ),  FTO_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FTO(KIAA1752);
    Protein name:
    Alpha-ketoglutarate-dependent dioxygenase FTO;
    Alternative:
    Fat mass and obesity-associated protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. May also exist as homodimer.
    Function:
    Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    505
    Sequence:
    50:
    MKRTPTAEER | EREAKKLRLL | EELEDTWLPY | LTPKDDEFYQ | QWQLKYPKLI | 
    100:
    LREASSVSEE | LHKEVQEAFL | TLHKHGCLFR | DLVRIQGKDL | LTPVSRILIG | 
    150:
    NPGCTYKYLN | TRLFTVPWPV | KGSNIKHTEA | EIAAACETFL | KLNDYLQIET | 
    200:
    IQALEELAAK | EKANEDAVPL | CMSADFPRVG | MGSSYNGQDE | VDIKSRAAYN | 
    250:
    VTLLNFMDPQ | KMPYLKEEPY | FGMGKMAVSW | HHDENLVDRS | AVAVYSYSCE | 
    300:
    GPEEESEDDS | HLEGRDPDIW | HVGFKISWDI | ETPGLAIPLH | QGDCYFMLDD | 
    350:
    LNATHQHCVL | AGSQPRFSST | HRVAECSTGT | LDYILQRCQL | ALQNVCDDVD | 
    400:
    NDDVSLKSFE | PAVLKQGEEI | HNEVEFEWLR | QFWFQGNRYR | KCTDWWCQPM | 
    450:
    AQLEALWKKM | EGVTNAVLHE | VKREGLPVEQ | RNEILTAILA | SLTARQNLRR | 
    500:
    EWHARCQSRI | ARTLPADQKP | ECRPYWEKDD | ASMPLPFDLT | DIVSELRGQL | 
    505:
    LEAKP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    SMR:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    E4267h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    E4267r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    E4267m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    U4267h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    U4267m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    U4267r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    P4267Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    P4267Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    P4267Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Monoclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Monoclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Protein for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Protein for Human Alpha-ketoglutarate-dependent dioxygenase FTO
    Protein for Human Alpha-ketoglutarate-dependent dioxygenase FTO

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Hattori A. , Kondo Y. , Okumura K. , Ohara O.
      DNA Res.7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      tissue: Brain.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4)
      tissue: Cervix.
      tissue: Eye.
      tissue: Lung.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PREDISPOSITION OF OBESITY;TISSUE SPECIFICITY
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PREDISPOSITION OF OBESITY;TISSUE SPECIFICITY
    6. 6.
      "Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO."
      Jia G. , Yang C.G. , Yang S. , Jian X. , Yi C. , Zhou Z. , He C.
      FEBS Lett.582:3313-3319(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
    7. 7.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-216;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO."
      Jia G. , Fu Y. , Zhao X. , Dai Q. , Zheng G. , Yang Y. , Yi C. , Lindahl T. , Pan T. , Yang Y.G. , He C.
      Nat. Chem. Biol.7:885-887(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF 231-HIS--ASP-233;CHARACTERIZATION OF VARIANT GDFD GLN-316
    10. 10.
      "Crystal structure of the FTO protein reveals basis for its substrate specificity."
      Han Z. , Niu T. , Chang J. , Lei X. , Zhao M. , Wang Q. , Cheng W. , Wang J. , Feng Y. , Chai J.
      Nature464:1205-1209(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 32-505 IN COMPLEX WITH IRON IONS; N-OXALYLGLYCINE AND 3-METHYLTHYMIDINE;CATALYTIC ACTIVITY;FUNCTION;COFACTOR;ENZYME REGULATION;MUTAGENESIS OF ARG-96; TYR-108; PHE-114; GLU-234 AND CYS-392;CIRCULAR DICHROISM;DOMAIN
    11. 11.
      "Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations."
      Boissel S. , Reish O. , Proulx K. , Kawagoe-Takaki H. , Sedgwick B. , Yeo G.S. , Meyre D. , Golzio C. , Molinari F. , Kadhom N. , Etchevers H.C. , Saudek V. , Farooqi I.S. , Froguel P. , Lindahl T. , O'Rahilly S. , Munnich A. , Colleaux L.
      Am. J. Hum. Genet.85:106-111(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GDFD GLN-316;CHARACTERIZATION OF VARIANT GDFD GLN-316
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