Gene name:
FTO (KIAA1752) ;
Protein name:
Alpha-ketoglutarate-dependent dioxygenase FTO ;
Alternative:
Fat mass and obesity-associated protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Monomer. May also exist as homodimer.
Function:
Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MKRTPTAEER | EREAKKLRLL | EELEDTWLPY | LTPKDDEFYQ | QWQLKYPKLI |
100:
LREASSVSEE | LHKEVQEAFL | TLHKHGCLFR | DLVRIQGKDL | LTPVSRILIG |
150:
NPGCTYKYLN | TRLFTVPWPV | KGSNIKHTEA | EIAAACETFL | KLNDYLQIET |
200:
IQALEELAAK | EKANEDAVPL | CMSADFPRVG | MGSSYNGQDE | VDIKSRAAYN |
250:
VTLLNFMDPQ | KMPYLKEEPY | FGMGKMAVSW | HHDENLVDRS | AVAVYSYSCE |
300:
GPEEESEDDS | HLEGRDPDIW | HVGFKISWDI | ETPGLAIPLH | QGDCYFMLDD |
350:
LNATHQHCVL | AGSQPRFSST | HRVAECSTGT | LDYILQRCQL | ALQNVCDDVD |
400:
NDDVSLKSFE | PAVLKQGEEI | HNEVEFEWLR | QFWFQGNRYR | KCTDWWCQPM |
450:
AQLEALWKKM | EGVTNAVLHE | VKREGLPVEQ | RNEILTAILA | SLTARQNLRR |
500:
EWHARCQSRI | ARTLPADQKP | ECRPYWEKDD | ASMPLPFDLT | DIVSELRGQL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
ELISA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
ELISA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
CLIA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
CLIA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
CLIA Kit for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Polyclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Polyclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Polyclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Monoclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Monoclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Monoclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Protein for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Protein for Human Alpha-ketoglutarate-dependent dioxygenase FTO
Protein for Human Alpha-ketoglutarate-dependent dioxygenase FTO
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4)
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Cited for : VARIANT GDFD GLN-316;CHARACTERIZATION OF VARIANT GDFD GLN-316