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Index > Protein center > G2E3(Gene name) > Human
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  • G2E3 (Gene name),
  • G2/M phase-specific E3 ubiquitin-protein ligase (Protein name ),  G2E3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    G2E3(KIAA1333);
    Protein name:
    G2/M phase-specific E3 ubiquitin-protein ligase;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
    Subcellular Location:
    Nucleus nucleolus Cytoplasm Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage.
    Protein Attributes:
    Sequence length:
    706
    Sequence:
    50:
    MNESKPGDSQ | NLACVFCRKH | DDCPNKYGEK | KTKEKWNLTV | HYYCLLMSSG | 
    100:
    IWQRGKEEEG | VYGFLIEDIR | KEVNRASKLK | CCVCKKNGAS | IGCVAPRCKR | 
    150:
    SYHFPCGLQR | ECIFQFTGNF | ASFCWDHRPV | QIITSNNYRE | SLPCTICLEF | 
    200:
    IEPIPSYNIL | RSPCCKNAWF | HRDCLQVQAI | NAGVFFFRCT | ICNNSDIFQK | 
    250:
    EMLRMGIHIP | EKDASWELEE | NAYQELLQHY | ERCDVRRCRC | KEGRDYNAPD | 
    300:
    SKWEIKRCQC | CGSSGTHLAC | SSLRSWEQNW | ECLECRGIIY | NSGEFQKAKK | 
    350:
    HVLPNSNNVG | ITDCLLEESS | PKLPRQSPGS | QSKDLLRQGS | KFRRNVSTLL | 
    400:
    IELGFQIKKK | TKRLYINKAN | IWNSALDAFR | NRNFNPSYAI | EVAYVIENDN | 
    450:
    FGSEHPGSKQ | EFLSLLMQHL | ENSSLFEGSL | SKNLSLNSQA | LKENLYYEAG | 
    500:
    KMLAISLVHG | GPSPGFFSKT | LFNCLVYGPE | NTQPILDDVS | DFDVAQIIIR | 
    550:
    INTATTVADL | KSIINECYNY | LELIGCLRLI | TTLSDKYMLV | KDILGYHVIQ | 
    600:
    RVHTPFESFK | QGLKTLGVLE | KIQAYPEAFC | SILCHKPESL | SAKILSELFT | 
    650:
    VHTLPDVKAL | GFWNSYLQAV | EDGKSTTTME | DILIFATGCS | SIPPAGFKPT | 
    700:
    PSIECLHVDF | PVGNKCNNCL | AIPITNTYKE | FQENMDFTIR | NTLRLEKEES | 
    706:
    SHYIGH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    MIM:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human G2/M phase-specific E3 ubiquitin-protein ligase
    ELISA Kit for Human G2/M phase-specific E3 ubiquitin-protein ligase
    ELISA Kit for Human G2/M phase-specific E3 ubiquitin-protein ligase
    CLIA Kit for Human G2/M phase-specific E3 ubiquitin-protein ligase
    CLIA Kit for Human G2/M phase-specific E3 ubiquitin-protein ligase
    CLIA Kit for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Polyclonal Antibody for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Polyclonal Antibody for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Polyclonal Antibody for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Monoclonal Antibody for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Monoclonal Antibody for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Monoclonal Antibody for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Protein for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Protein for Human G2/M phase-specific E3 ubiquitin-protein ligase
    Protein for Human G2/M phase-specific E3 ubiquitin-protein ligase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization."
      Brooks W.S. , Banerjee S. , Crawford D.F.
      Exp. Cell Res.313:665-676(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;MUTAGENESIS OF 30-LYS-LYS-31 AND CYS-666
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];TISSUE SPECIFICITY
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Hepatoma.
      tissue: Teratocarcinoma.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    5. 5.
      "The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators."
      Crawford D.F. , Piwnica-Worms H.
      J. Biol. Chem.276:37166-37177(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    6. 6.
      "G2E3 is a dual function ubiquitin ligase required for early embryonic development."
      Brooks W.S. , Helton E.S. , Banerjee S. , Venable M. , Johnson L. , Schoeb T.R. , Kesterson R.A. , Crawford D.F.
      J. Biol. Chem.283:22304-22315(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;MUTAGENESIS OF CYS-84; CYS-147; CYS-258; CYS-261 AND CYS-666
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