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Index > Protein center > GAPDH(Gene name) > Bovine
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  • GAPDH (Gene name),
  • Glyceraldehyde-3-phosphate dehydrogenase (Protein name ),  G3P_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    GAPDH(GAPD);
    Protein name:
    Glyceraldehyde-3-phosphate dehydrogenase(GAPDH);
    Alternative:
    2.6.99.-;Peptidyl-cysteine S-nitrosylase GAPDH);
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Homotetramer. Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation.
    Function:
    Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
    Subcellular Location:
    Cytoplasm cytosol Nucleus Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.
    Protein Attributes:
    Sequence length:
    333
    Sequence:
    50:
    MVKVGVNGFG | RIGRLVTRAA | FNSGKVDIVA | INDPFIDLHY | MVYMFQYDST | 
    100:
    HGKFNGTVKA | ENGKLVINGK | AITIFQERDP | ANIKWGDAGA | EYVVESTGVF | 
    150:
    TTMEKAGAHL | KGGAKRVIIS | APSADAPMFV | MGVNHEKYNN | TLKIVSNASC | 
    200:
    TTNCLAPLAK | VIHDHFGIVE | GLMTTVHAIT | ATQKTVDGPS | GKLWRDGRGA | 
    250:
    AQNIIPASTG | AAKAVGKVIP | ELNGKLTGMA | FRVPTPNVSV | VDLTCRLEKP | 
    300:
    AKYDEIKKVV | KQASEGPLKG | ILGYTEDQVV | SCDFNSDTHS | STFDAGAGIA | 
    333:
    LNDHFVKLIS | WYDNEFGYSN | RVVDLMVHMA | SKE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine GAPDH
    Cat.:
    E1932m
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    Packing:
    96T
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    ELISA Kit for Bovine GAPDH
    Cat.:
    E1932h
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    Packing:
    96T
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    ELISA Kit for Bovine GAPDH
    Cat.:
    E1932d
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    96T
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    ELISA Kit for Bovine GAPDH
    Cat.:
    E1932r
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    96T
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    ELISA Kit for Bovine GAPDH
    MSDS:
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    ELISA Kit for Bovine GAPDH
    Cat.:
    E1932p
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    Packing:
    96T
    ELISA Kit for Bovine GAPDH
    Cat.:
    E1932b
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    96T
    ELISA Kit for Bovine GAPDH
    Cat.:
    E1932c
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    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    Cat.:
    U1932b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    Cat.:
    U1932d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    Cat.:
    U1932m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    Cat.:
    U1932p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    Cat.:
    U1932c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    Cat.:
    U1932r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    Cat.:
    U1932h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine GAPDH
    MSDS:
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    Polyclonal Antibody for Bovine GAPDH
    Cat.:
    P1932Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine GAPDH
    Cat.:
    P1932Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine GAPDH
    Polyclonal Antibody for Bovine GAPDH
    Polyclonal Antibody for Bovine GAPDH
    Polyclonal Antibody for Bovine GAPDH
    Polyclonal Antibody for Bovine GAPDH
    Polyclonal Antibody for Bovine GAPDH
    Cat.:
    P1932Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine GAPDH
    Monoclonal Antibody for Bovine GAPDH
    Monoclonal Antibody for Bovine GAPDH
    Monoclonal Antibody for Bovine GAPDH
    Monoclonal Antibody for Bovine GAPDH
    Monoclonal Antibody for Bovine GAPDH
    Monoclonal Antibody for Bovine GAPDH
    Monoclonal Antibody for Bovine GAPDH
    Protein for Bovine GAPDH
    Protein for Bovine GAPDH
    Protein for Bovine GAPDH
    Protein for Bovine GAPDH
    Cat.:
    R1932h
    Price:
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Bovine GAPDH
    Protein for Bovine GAPDH
    Protein for Bovine GAPDH
    Protein for Bovine GAPDH

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    References
    1. 1.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2005-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Crossbred X Angus.
      tissue: Ileum.
    2. 2.
      "Structural evidence for a liver-specific glyceraldehyde-3-phosphate dehydrogenase."
      Kulbe K.D. , Jackson K.W. , Tang J.
      Biochem. Biophys. Res. Commun.67:35-42(1975) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-31
      tissue: Liver.
    3. 3.
      "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies."
      Olah J. , Toekesi N. , Vincze O. , Horvath I. , Lehotzky A. , Erdei A. , Szajli E. , Medzihradszky K.F. , Orosz F. , Kovacs G.G. , Ovadi J.
      FEBS Lett.580:5807-5814(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11;INTERACTION WITH TPPP
    4. 4.
      Mertens B. , Muriuki C.
      Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-321
      tissue: Lymphocyte.
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