GABBR1 ELISA Kit for Human(Homo sapiens) | EIAab.comGABBR1 ELISA Kit for Human(Homo sapiens)

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GABBR1 (Gene name),

Gamma-aminobutyric acid type B receptor subunit 1 (Protein name ), GABR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GABBR1(GPRC3A);

Protein name:

Gamma-aminobutyric acid type B receptor subunit 1(GABA-B receptor 1;GABA-B-R1;GABA-BR1;GABABR1;Gb1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.

Function:

Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Subcellular Location:

Isoform 1E Secreted

Protein Attributes:

Sequence length:

961

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

961:

CDGSRVHLLY | K

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

603540

STRING:

9606.ENSP00000388035

String:

Q9UBS5

UniGene:

Hs.167017

SMR:

Q9UBS5

KEGG:

hsa:2550

Pfam:

PF00003

Uniprot:

Q9UBS5

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ELISA Kit for Human GABA-B receptor 1

Cat.:

E2151h

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Manual:

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96T

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ELISA Kit for Human GABA-B receptor 1

Cat.:

E2151r

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96T

ELISA Kit for Human GABA-B receptor 1

Cat.:

E2151m

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96T

CLIA Kit for Human GABA-B receptor 1

Cat.:

U2151m

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96T

CLIA Kit for Human GABA-B receptor 1

Cat.:

U2151r

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MSDS:

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Packing:

96T

CLIA Kit for Human GABA-B receptor 1

Cat.:

U2151h

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96T

Polyclonal Antibody for Human GABA-B receptor 1

Cat.:

P2151Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human GABA-B receptor 1

Cat.:

P2151Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human GABA-B receptor 1

Cat.:

P2151Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human GABA-B receptor 1

Protein for Human GABA-B receptor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels."
Kaupmann K. , Schuler V. , Mosbacher J. , Bischoff S. , Bittiger H. , Heid J. , Froestl W. , Leonhard S. , Pfaff T. , Karschin A. , Bettler B.
Proc. Natl. Acad. Sci. U.S.A.95:14991-14996(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Cerebellum.
2.

"Heterodimerization is required for the formation of a functional GABA(B) receptor."
White J.H. , Wise A. , Main M.J. , Green A. , Fraser N.J. , Disney G.H. , Barnes A.A. , Emson P. , Foord S.M. , Marshall F.H.
Nature396:679-682(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B AND 1C);FUNCTION;SUBUNIT;INTERACTION WITH GABBR2;SUBCELLULAR LOCATION
tissue: Cerebellum.
3.

"Human mRNA for GABA-B1a receptor."
Stropp U. , Raming K.
Submitted (1998-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A)
tissue: Brain.
4.

"GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene."
Grifa A. , Totaro A. , Rommens J.M. , Carella M. , Roetto A. , Borgato L. , Zelante L. , Gasparini P.
Biochem. Biophys. Res. Commun.250:240-245(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A)
tissue: Fetal brain.
5.

"Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization."
Goei V.L. , Choi J. , Ahn J. , Bowlus C.L. , Raha-Chowdhury R. , Gruen J.R.
Biol. Psychiatry44:659-666(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1A)
6.

Fraser N.J.
Submitted (1998-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1C)
tissue: Cerebellum.
7.

"Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy."
Peters H.C. , Kaemmer G. , Volz A. , Kaupmann K. , Ziegler A. , Bettler B. , Epplen J.T. , Sander T. , Riess O.
Neurogenetics2:47-54(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1A AND 1B);VARIANTS VAL-20 AND SER-489
tissue: Fetal brain.
8.

"Molecular cloning of human GABABR1 and its tissue distribution."
Makoff A.
Brain Res. Mol. Brain Res.64:137-140(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A)
tissue: Cerebellum.
9.

"Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor."
Schwarz D.A. , Barry G. , Eliasof S.D. , Petroski R.E. , Conlon P.J. , Maki R.A.
J. Biol. Chem.275:32174-32181(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1E);VARIANT SER-489
tissue: Prostate.
10.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT VAL-20
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1B)
tissue: Brain.
13.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
14.

"Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor."
Sullivan R. , Chateauneuf A. , Coulombe N. , Kolakowski L.F. Jr. , Johnson M.P. , Hebert T.E. , Ethier N. , Belley M. , Metters K. , Abramovitz M. , O'Neill G.P. , Ng G.Y.K.
J. Pharmacol. Exp. Ther.293:460-467(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR2
15.

"Role of heteromer formation in GABAB receptor function."
Kuner R. , Koehr G. , Gruenewald S. , Eisenhardt G. , Bach A. , Kornau H.-C.
Science283:74-77(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR2
16.

"Marlin-1, a novel RNA-binding protein associates with GABA receptors."
Couve A. , Restituito S. , Brandon J.M. , Charles K.J. , Bawagan H. , Freeman K.B. , Pangalos M.N. , Calver A.R. , Moss S.J.
J. Biol. Chem.279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAKMIP1
17.

"Subcellular distribution of GABA(B) receptor homo- and hetero-dimers."
Villemure J.F. , Adam L. , Bevan N.J. , Gearing K. , Chenier S. , Bouvier M.
Biochem. J.388:47-55(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
18.

"Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor."
Nomura R. , Suzuki Y. , Kakizuka A. , Jingami H.
J. Biol. Chem.283:4665-4673(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GABBR2
19.

"Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2."
Geng Y. , Xiong D. , Mosyak L. , Malito D.L. , Kniazeff J. , Chen Y. , Burmakina S. , Quick M. , Bush M. , Javitch J.A. , Pin J.P. , Fan Q.R.
Nat. Neurosci.15:970-978(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PARTIAL PROTEIN SEQUENCE;AGONIST BINDING;MUTAGENESIS OF TYR-230 AND TYR-234;INTERACTION WITH GABBR2
20.

"Structural mechanism of ligand activation in human GABA(B) receptor."
Geng Y. , Bush M. , Mosyak L. , Wang F. , Fan Q.R.
Nature504:254-259(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 165-576 IN COMPLEXES WITH GABBR2; AGONISTS AND ANTAGONISTS;FUNCTION;SUBUNIT;DISULFIDE BOND;GLYCOSYLATION AT ASN-440 AND ASN-482;MUTAGENESIS OF TRP-182; HIS-287; TYR-367 AND TRP-395
21.

"Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy."
Sander T. , Peters C. , Kaemmer G. , Samochowiec J. , Zirra M. , Mischke D. , Ziegler A. , Kaupmann K. , Bettler B. , Epplen J.T. , Riess O.
Am. J. Med. Genet.88:305-310(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-20 AND SER-489

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