MCM3AP ELISA Kit for Human(Homo sapiens) | EIAab.comMCM3AP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MCM3AP(Gene name) > Human

MCM3AP (Gene name),

Germinal-center associated nuclear protein (Protein name ), GANP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MCM3AP(GANP;KIAA0572;MAP80);

Protein name:

Germinal-center associated nuclear protein(GANP);

Alternative:

2.3.1.-;MCM3 acetylating protein(MCM3AP);80 kDa MCM3-associated protein;MCM3 acetyltransferase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with AICDA/AID (By similarity). Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, two copies of ENY2, PCID2, DSS1, and either centrin CETN2 or CETN3. Isoform MCM3AP interacts with MCM3. Interacts with NXF1 (By via FG-repeats).

Function:

Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.

Subcellular Location:

Isoform MCM3AP Cytoplasm Nucleus Nucleoplasm Binding to MCM3 is required for nuclear import, associates with chromatin.

Protein Attributes:

Sequence length:

1980

Sequence:

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1980:

KHLERLIRSS | REEEVASELH | LSALLDMVDI |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

603294

UniGene:

Hs.389037

STRING:

9606.ENSP00000291688

SMR:

O60318

Pfam:

PF03399

KEGG:

hsa:8888

Uniprot:

O60318

FOR

ELISA Kit for Human GANP

CLIA Kit for Human GANP

Polyclonal Antibody for Human GANP

Monoclonal Antibody for Human GANP

Protein for Human GANP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication."
Abe E. , Kuwahara K. , Yoshida M. , Suzuki M. , Terasaki H. , Matsuo Y. , Takahashi E. , Sakaguchi N.
Gene255:219-227(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

NIEHS SNPs program
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-102; VAL-288; LEU-333; LEU-413; LEU-1051; MET-1062; TRP-1314; GLU-1449; ILE-1576; THR-1795; ARG-1870 AND VAL-1941
3.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-102
tissue: Brain.
5.

"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1980
tissue: Brain.
6.

"Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization."
Takei Y. , Tsujimoto G.
J. Biol. Chem.273:22177-22180(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1260-1980
7.

"MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3."
Takei Y. , Swietlik M. , Tanoue A. , Tsujimoto G. , Kouzarides T. , Laskey R.
EMBO Rep.2:119-123(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM MCM3AP);SUBCELLULAR LOCATION (ISOFORM MCM3AP);INTERACTION WITH MCM3;MUTAGENESIS OF 1730-HIS--GLY-1733
8.

"The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3."
Takei Y. , Assenberg M. , Tsujimoto G. , Laskey R.
J. Biol. Chem.277:43121-43125(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM MCM3AP)
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
12.

"mRNA export from mammalian cell nuclei is dependent on GANP."
Wickramasinghe V.O. , McMurtrie P.I. , Mills A.D. , Takei Y. , Penrhyn-Lowe S. , Amagase Y. , Main S. , Marr J. , Stewart M. , Laskey R.A.
Curr. Biol.20:25-31(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM GANP);SUBCELLULAR LOCATION;FG-REPEATS;INTERACTION WITH NXF1
13.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP."
Wickramasinghe V.O. , McMurtrie P.I. , Marr J. , Amagase Y. , Main S. , Mills A.D. , Laskey R.A. , Takei Y.
J. Mol. Biol.406:355-361(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE PROMOTER USAGE;SUBCELLULAR LOCATION
15.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export."
Jani D. , Lutz S. , Hurt E. , Laskey R.A. , Stewart M. , Wickramasinghe V.O.
Nucleic Acids Res.40:4562-4573(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1163-1235 IN COMPLEX WITH ENY2;FUNCTION;SUBUNIT;IDENTIFICATION IN THE TREX-2 COMPLEX;SUBCELLULAR LOCATION
17.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-409 AND ILE-1576
18.

"Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing."
Schuurs-Hoeijmakers J.H. , Vulto-van Silfhout A.T. , Vissers L.E. , van de Vondervoort I.I. , van Bon B.W. , de Ligt J. , Gilissen C. , Hehir-Kwa J.Y. , Neveling K. , del Rosario M. , Hira G. , Reitano S. , Vitello A. , Failla P. , Greco D. , Fichera M. , Galesi O. , Kleefstra T. , more...
J. Med. Genet.50:802-811(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-915

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