Mcm3ap ELISA Kit for Mouse(Mus musculus) | EIAab.comMcm3ap ELISA Kit for Mouse(Mus musculus)

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Mcm3ap (Gene name),

Germinal-center associated nuclear protein (Protein name ), GANP_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mcm3ap(Ganp;Map80);

Protein name:

Germinal-center associated nuclear protein(GANP);

Alternative:

GC-associated DNA primase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, two copies of ENY2, PCID2, DSS1, and either centrin CETN2 or CETN3. Interacts with NXF1 (By via FG-repeats) (By similarity). Interacts with MCM3. Interacts with AICDA/AID.

Function:

Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity). Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells.

Subcellular Location:

Cytoplasm Nucleus Nucleus Nuclear pore complex In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene.

Protein Attributes:

Sequence length:

1971

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SRAEEAASEL | HLSALLEMVD | M

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.30098

SMR:

Q9WUU9

KEGG:

mmu:54387

Pfam:

PF03399

Uniprot:

Q9WUU9

FOR

ELISA Kit for Mouse GANP

CLIA Kit for Mouse GANP

Polyclonal Antibody for Mouse GANP

Monoclonal Antibody for Mouse GANP

Protein for Mouse GANP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication."
Kuwahara K. , Yoshida M. , Kondo E. , Sakata A. , Watanabe Y. , Abe E. , Kouno Y. , Tomiyasu S. , Fujimura S. , Tokuhisa T. , Kimura H. , Ezaki T. , Sakaguchi N.
Blood95:2321-2328(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH MCM3;TISSUE SPECIFICITY
strain: BALB/c X NZB.
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
4.

"Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions."
Kuwahara K. , Tomiyasu S. , Fujimura S. , Nomura K. , Xing Y. , Nishiyama N. , Ogawa M. , Imajoh-Ohmi S. , Izuta S. , Sakaguchi N.
Proc. Natl. Acad. Sci. U.S.A.98:10279-10283(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-502;MUTAGENESIS OF SER-502
5.

"GANP suppresses DNA recombination, measured by direct-repeat beta-galactosidase gene construct, but does not suppress the type of recombination applying to immunoglobulin genes in mammalian cells."
Yoshida M. , Kuwahara K. , Shimasaki T. , Nakagata N. , Matsuoka M. , Sakaguchi N.
Genes Cells12:1205-1213(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
6.

"Molecular mechanism of immunoglobulin V-region diversification regulated by transcription and RNA metabolism in antigen-driven B cells."
Sakaguchi N. , Maeda K. , Kuwahara K.
Scand. J. Immunol.73:520-526(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH AICDA;SUBCELLULAR LOCATION
7.

"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J. , Newman J.C. , Held J.M. , Cusack M.P. , Sorensen D.J. , Li B. , Schilling B. , Mooney S.D. , Kahn C.R. , Verdin E. , Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-483 AND LYS-484;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.

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