Protein name:
Transcription factor GATA-4 ;
Alternative:
GATA-binding factor 4 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1 (By similarity). Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.
Function:
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MYQSLAMAAN | HGPPPGAYEA | GGPGAFMHGA | GAASSPVYVP | TPRVPSSVLG |
100:
LSYLQGGGAG | SASGGASGGS | SGGAASGAGP | GTQQGSPGWS | QAGADGAAYT |
150:
PPPVSPRFSF | PGTTGSLAAA | AAAAAAREAA | AYSSGGGAAG | AGLAGREQYG |
200:
RAGFAGSYSS | PYPAYMADVG | ASWAAAAAAS | AGPFDSPVLH | SLPGRANPAA |
250:
RHPNLDMFDD | FSEGRECVNC | GAMSTPLWRR | DGTGHYLCNA | CGLYHKMNGI |
300:
NRPLIKPQRR | LSASRRVGLS | CANCQTTTTT | LWRRNAEGEP | VCNACGLYMK |
350:
LHGVPRPLAM | RKEGIQTRKR | KPKNLNKSKT | PAAPSGSESL | PPASGASSNS |
400:
SNATTSSSEE | MRPIKTEPGL | SSHYGHSSSV | SQTFSVSAMS | GHGPSIHPVL |
442:
SALKLSPQGY | ASPVSQSPQT | SSKQDSWNSL | VLADSHGDII | TA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Dog
ELISA Kit for Human Transcription factor GATA-4
ELISA Kit for Human Transcription factor GATA-4
ELISA Kit for Human Transcription factor GATA-4
ELISA Kit for Human Transcription factor GATA-4
ELISA Kit for Human Transcription factor GATA-4
CLIA Kit for Human Transcription factor GATA-4
CLIA Kit for Human Transcription factor GATA-4
CLIA Kit for Human Transcription factor GATA-4
CLIA Kit for Human Transcription factor GATA-4
CLIA Kit for Human Transcription factor GATA-4
Polyclonal Antibody for Human Transcription factor GATA-4
Polyclonal Antibody for Human Transcription factor GATA-4
Polyclonal Antibody for Human Transcription factor GATA-4
Polyclonal Antibody for Human Transcription factor GATA-4
Polyclonal Antibody for Human Transcription factor GATA-4
Monoclonal Antibody for Human Transcription factor GATA-4
Monoclonal Antibody for Human Transcription factor GATA-4
Monoclonal Antibody for Human Transcription factor GATA-4
Monoclonal Antibody for Human Transcription factor GATA-4
Monoclonal Antibody for Human Transcription factor GATA-4
Protein for Human Transcription factor GATA-4
Protein for Human Transcription factor GATA-4
Protein for Human Transcription factor GATA-4
Protein for Human Transcription factor GATA-4
Protein for Human Transcription factor GATA-4
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Heart .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
"DNA sequence and analysis of human chromosome 8."
Nusbaum C.
,
Mikkelsen T.S.
,
Zody M.C.
,
Asakawa S.
,
Taudien S.
,
Garber M.
,
Kodira C.D.
,
Schueler M.G.
,
Shimizu A.
,
Whittaker C.A.
,
Chang J.L.
,
Cuomo C.A.
,
Dewar K.
,
FitzGerald M.G.
,
Yang X.
,
Allen N.R.
,
Anderson S.
,
Asakawa T.
,
Blechschmidt K.
,
Bloom T.
,
Borowsky M.L.
,
Butler J.
,
Cook A.
,
Corum B.
,
DeArellano K.
,
DeCaprio D.
,
Dooley K.T.
,
Dorris L. III
,
Engels R.
,
Gloeckner G.
,
Hafez N.
,
Hagopian D.S.
,
Hall J.L.
,
Ishikawa S.K.
,
Jaffe D.B.
,
Kamat A.
,
Kudoh J.
,
Lehmann R.
,
Lokitsang T.
,
Macdonald P.
,
Major J.E.
,
Matthews C.D.
,
Mauceli E.
,
Menzel U.
,
Mihalev A.H.
,
Minoshima S.
,
Murayama Y.
,
Naylor J.W.
,
Nicol R.
,
Nguyen C.
,
O'Leary S.B.
,
O'Neill K.
,
Parker S.C.J.
,
Polley A.
,
Raymond C.K.
,
Reichwald K.
,
Rodriguez J.
,
Sasaki T.
,
Schilhabel M.
,
Siddiqui R.
,
Smith C.L.
,
Sneddon T.P.
,
Talamas J.A.
,
Tenzin P.
,
Topham K.
,
Venkataraman V.
,
Wen G.
,
Yamazaki S.
,
Young S.K.
,
Zeng Q.
,
Zimmer A.R.
,
Rosenthal A.
,
Birren B.W.
,
Platzer M.
,
Shimizu N.
,
Lander E.S.
more...
Nature439:331-335(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Heart .
tissue :
Lung .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN CARDIAC HYPERTROPHY;IDENTIFICATION IN COMPLEX WITH CCNT1; EP300 AND GATA4
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;DNA-BINDING;INTERACTION WITH NR5A1 AND ZFPM2;VARIANT TACHD ARG-221;CHARACTERIZATION OF VARIANT TACHD ARG-221
8.
"GATA4 loss-of-function mutations underlie familial tetralogy of fallot."
Yang Y.Q.
,
Gharibeh L.
,
Li R.G.
,
Xin Y.F.
,
Wang J.
,
Liu Z.M.
,
Qiu X.B.
,
Xu Y.J.
,
Xu L.
,
Qu X.K.
,
Liu X.
,
Fang W.Y.
,
Huang R.T.
,
Xue S.
,
Nemer G.
Hum. Mutat.34:1662-1671(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TBX5;VARIANTS TOF PRO-9; VAL-51 AND SER-285;CHARACTERIZATION OF VARIANTS TOF PRO-9; VAL-51 AND SER-285
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 262-321
10.
"GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5."
Garg V.
,
Kathiriya I.S.
,
Barnes R.
,
Schluterman M.K.
,
King I.N.
,
Butler C.A.
,
Rothrock C.R.
,
Eapen R.S.
,
Hirayama-Yamada K.
,
Joo K.
,
Matsuoka R.
,
Cohen J.C.
,
Srivastava D.
Nature424:443-447(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASD2 SER-296
11.
"Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect."
Hirayama-Yamada K.
,
Kamisago M.
,
Akimoto K.
,
Aotsuka H.
,
Nakamura Y.
,
Tomita H.
,
Furutani M.
,
Imamura S.
,
Takao A.
,
Nakazawa M.
,
Matsuoka R.
Am. J. Med. Genet. A135:47-52(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ASD2 PHE-52 AND SER-296
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ASD2 ALA-93; GLU-316 AND ASN-425;VARIANT VSD1 VAL-411
13.
"Spectrum of heart disease associated with murine and human GATA4 mutation."
Rajagopal S.K.
,
Ma Q.
,
Obler D.
,
Shen J.
,
Manichaikul A.
,
Tomita-Mitchell A.
,
Boardman K.
,
Briggs C.
,
Garg V.
,
Srivastava D.
,
Goldmuntz E.
,
Broman K.W.
,
Benson D.W.
,
Smoot L.B.
,
Pu W.T.
J. Mol. Cell. Cardiol.43:677-685(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ASD2 CYS-296 AND MET-403;VARIANTS AVSD4 SER-163 AND VAL-346
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS VSD1 VAL-6; SER-46 DEL; SER-163; LYS-359; THR-429 AND VAL-442;VARIANTS TOF ALA-118 INS AND GLN-407
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASD2 MET-280
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT VSD1 GLN-407;VARIANT TOF SER-163
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASD2 VAL-310
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT VSD1 ARG-296
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT VSD1 TRP-43;CHARACTERIZATION OF VARIANT VSD1 TRP-43