Protein name:
Gamma-aminobutyric acid receptor subunit beta-2 ;
Alternative:
GABA(A) receptor subunit beta-2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents.
Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular Location:
Cell junction
synapse
postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MWRVRKRGYF | GIWSFPLIIA | AVCAQSVNDP | SNMSLVKETV | DRLLKGYDIR |
100:
LRPDFGGPPV | AVGMNIDIAS | IDMVSEVNMD | YTLTMYFQQA | WRDKRLSYNV |
150:
IPLNLTLDNR | VADQLWVPDT | YFLNDKKSFV | HGVTVKNRMI | RLHPDGTVLY |
200:
GLRITTTAAC | MMDLRRYPLD | EQNCTLEIES | YGYTTDDIEF | YWRGDDNAVT |
250:
GVTKIELPQF | SIVDYKLITK | KVVFSTGSYP | RLSLSFKLKR | NIGYFILQTY |
300:
MPSILITILS | WVSFWINYDA | SAARVALGIT | TVLTMTTINT | HLRETLPKIP |
350:
YVKAIDMYLM | GCFVFVFMAL | LEYALVNYIF | FGRGPQRQKK | AAEKAASANN |
400:
EKMRLDVNKI | FYKDIKQNGT | QYRSLWDPTG | NLSPTRRTTN | YDFSLYTMDP |
450:
HENILLSTLE | IKNEMATSEA | VMGLGDPRST | MLAYDASSIQ | YRKAGLPRHS |
500:
FGRNALERHV | AQKKSRLRRR | ASQLKITIPD | LTDVNAIDRW | SRIFFPVVFS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Bovine
ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
Protein for Human Gamma-aminobutyric acid receptor subunit beta-2
Protein for Human Gamma-aminobutyric acid receptor subunit beta-2
Protein for Human Gamma-aminobutyric acid receptor subunit beta-2
Protein for Human Gamma-aminobutyric acid receptor subunit beta-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);TISSUE SPECIFICITY;MUTAGENESIS OF THR-389;FUNCTION;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING
tissue :
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Nat. Genet.36:40-45(2004)
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
5.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-45
tissue :
Mammary cancer .