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Index > Protein center > GABRB2(Gene name) > Human
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  • GABRB2 (Gene name),
  • Gamma-aminobutyric acid receptor subunit beta-2 (Protein name ),  GBRB2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GABRB2;
    Protein name:
    Gamma-aminobutyric acid receptor subunit beta-2;
    Alternative:
    GABA(A) receptor subunit beta-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents.
    Function:
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    Subcellular Location:
    Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    512
    Sequence:
    50:
    MWRVRKRGYF | GIWSFPLIIA | AVCAQSVNDP | SNMSLVKETV | DRLLKGYDIR | 
    100:
    LRPDFGGPPV | AVGMNIDIAS | IDMVSEVNMD | YTLTMYFQQA | WRDKRLSYNV | 
    150:
    IPLNLTLDNR | VADQLWVPDT | YFLNDKKSFV | HGVTVKNRMI | RLHPDGTVLY | 
    200:
    GLRITTTAAC | MMDLRRYPLD | EQNCTLEIES | YGYTTDDIEF | YWRGDDNAVT | 
    250:
    GVTKIELPQF | SIVDYKLITK | KVVFSTGSYP | RLSLSFKLKR | NIGYFILQTY | 
    300:
    MPSILITILS | WVSFWINYDA | SAARVALGIT | TVLTMTTINT | HLRETLPKIP | 
    350:
    YVKAIDMYLM | GCFVFVFMAL | LEYALVNYIF | FGRGPQRQKK | AAEKAASANN | 
    400:
    EKMRLDVNKI | FYKDIKQNGT | QYRSLWDPTG | NLSPTRRTTN | YDFSLYTMDP | 
    450:
    HENILLSTLE | IKNEMATSEA | VMGLGDPRST | MLAYDASSIQ | YRKAGLPRHS | 
    500:
    FGRNALERHV | AQKKSRLRRR | ASQLKITIPD | LTDVNAIDRW | SRIFFPVVFS | 
    512:
    FFNIVYWLYY | VN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit beta-2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit beta-2
    Protein for Human Gamma-aminobutyric acid receptor subunit beta-2
    Protein for Human Gamma-aminobutyric acid receptor subunit beta-2
    Protein for Human Gamma-aminobutyric acid receptor subunit beta-2
    Protein for Human Gamma-aminobutyric acid receptor subunit beta-2

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    Precision
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    Linearity
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    References
    1. 1.
      "Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors."
      Hadingham K.L. , Wingrove P.B. , Wafford K.A. , Bain C. , Kemp J.A. , Palmer K.J. , Wilson A.W. , Wilcox A.S. , Sikela J.M. , Ragan C.I.
      Mol. Pharmacol.44:1211-1218(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
      tissue: Brain.
    2. 2.
      "Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor."
      McKinley D.D. , Lennon D.J. , Carter D.B.
      Brain Res. Mol. Brain Res.28:175-179(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    3. 3.
      "Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders."
      Zhao C. , Xu Z. , Wang F. , Chen J. , Ng S.K. , Wong P.W. , Yu Z. , Pun F.W. , Ren L. , Lo W.S. , Tsang S.Y. , Xue H.
      PLoS ONE4:E6977-E6977(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);TISSUE SPECIFICITY;MUTAGENESIS OF THR-389;FUNCTION;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    7. 7.
      "Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia."
      Zhao C. , Xu Z. , Chen J. , Yu Z. , Tong K.L. , Lo W.S. , Pun F.W. , Ng S.K. , Tsang S.Y. , Xue H.
      Mol. Psychiatry11:1092-1105(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J. , Vasilescu J. , Lambert J.-P. , Smith J.C. , Figeys D.
      Proteomics7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-45
      tissue: Mammary cancer.
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