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Index > Protein center > GABARAPL2(Gene name) > Human
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  • GABARAPL2 (Gene name),
  • Gamma-aminobutyric acid receptor-associated protein-like 2 (Protein name ),  GBRL2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GABARAPL2(FLC3A;GEF2);
    Protein name:
    Gamma-aminobutyric acid receptor-associated protein-like 2;
    Alternative:
    Ganglioside expression factor 2(GEF-2);GABA(A) receptor-associated protein-like 2;Golgi-associated ATPase enhancer of 16 kDa(GATE-16);General protein transport factor p16;MAP1 light chain 3-related protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.
    Function:
    Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.
    Subcellular Location:
    Golgi apparatus
    Protein Attributes:
    Sequence length:
    117
    Sequence:
    50:
    MKWMFKEDHS | LEHRCVESAK | IRAKYPDRVP | VIVEKVSGSQ | IVDIDKRKYL | 
    100:
    VPSDITVAQF | MWIIRKRIQL | PSEKAIFLFV | DKTVPQSSLT | MGQLYEKEKD | 
    117:
    EDGFLYVAYS | GENTFGF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    KEGG:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    ELISA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    ELISA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    ELISA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    CLIA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    CLIA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    CLIA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    CLIA Kit for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein for Human Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein for Human Gamma-aminobutyric acid receptor-associated protein-like 2

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    Linearity
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    References
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      "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."
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      Brain Res. Mol. Brain Res.85:1-12(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INTERACTION WITH ULK1
      tissue: Frontal cortex.
    2. 2.
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      Storch S. , Braulke T.
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      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
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      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
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      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Testis.
    9. 9.
      "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
      Tanida I. , Tanida-Miyake E. , Ueno T. , Kominami E.
      J. Biol. Chem.276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG7
    10. 10.
      "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
      Tanida I. , Tanida-Miyake E. , Komatsu M. , Ueno T. , Kominami E.
      J. Biol. Chem.277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG3
    11. 11.
      "GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3."
      Tanida I. , Komatsu M. , Ueno T. , Kominami E.
      Biochem. Biophys. Res. Commun.300:637-644(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIPIDATION AT GLY-116;INTERACTION WITH ATG3 AND ATG7;SUBCELLULAR LOCATION
    12. 12.
      "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation."
      Kabeya Y. , Mizushima N. , Yamamoto A. , Oshitani-Okamoto S. , Ohsumi Y. , Yoshimori T.
      J. Cell Sci.117:2805-2812(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE;SUBCELLULAR LOCATION;MUTAGENESIS OF GLY-116
    13. 13.
      "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
      Pankiv S. , Clausen T.H. , Lamark T. , Brech A. , Bruun J.A. , Outzen H. , Overvatn A. , Bjorkoy G. , Johansen T.
      J. Biol. Chem.282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1;SUBCELLULAR LOCATION
    14. 14.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH TP53INP2
    16. 16.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-24;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis."
      Weidberg H. , Shvets E. , Shpilka T. , Shimron F. , Shinder V. , Elazar Z.
      EMBO J.29:1792-1802(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "Network organization of the human autophagy system."
      Behrends C. , Sowa M.E. , Gygi S.P. , Harper J.W.
      Nature466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TECPR2
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."
      Itoh T. , Kanno E. , Uemura T. , Waguri S. , Fukuda M.
      J. Cell Biol.192:839-853(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D25
    21. 21.
      "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
      Tang Z. , Lin M.G. , Stowe T.R. , Chen S. , Zhu M. , Stearns T. , Franco B. , Zhong Q.
      Nature502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION PCM1
    22. 22.
      "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
      Seillier M. , Peuget S. , Gayet O. , Gauthier C. , N'guessan P. , Monte M. , Carrier A. , Iovanna J.L. , Dusetti N.J.
      Cell Death Differ.19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53INP1
    23. 23.
      "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."
      Alemu E.A. , Lamark T. , Torgersen K.M. , Birgisdottir A.B. , Larsen K.B. , Jain A. , Olsvik H. , Overvatn A. , Kirkin V. , Johansen T.
      J. Biol. Chem.287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG13 AND ULK1
    24. 24.
      "Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."
      Popovic D. , Akutsu M. , Novak I. , Harper J.W. , Behrends C. , Dikic I.
      Mol. Cell. Biol.32:1733-1744(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D5
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
    26. 26.
      "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
      Sancho A. , Duran J. , Garcia-Espana A. , Mauvezin C. , Alemu E.A. , Lamark T. , Macias M.J. , Desalle R. , Royo M. , Sala D. , Chicote J.U. , Palacin M. , Johansen T. , Zorzano A.
      PLoS ONE7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53INP1 AND TP53INP2
    27. 27.
      "Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."
      Zhu Y. , Massen S. , Terenzio M. , Lang V. , Chen-Lindner S. , Eils R. , Novak I. , Dikic I. , Hamacher-Brady A. , Brady N.R.
      J. Biol. Chem.288:1099-1113(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BNIP3;FUNCTION
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