NR3C1 ELISA Kit for Human(Homo sapiens) | EIAab.comNR3C1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > NR3C1(Gene name) > Human

NR3C1 (Gene name),

Glucocorticoid receptor (Protein name ), GCR_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

NR3C1(GRL);

Protein name:

Glucocorticoid receptor(GR);

Alternative:

Nuclear receptor subfamily 3 group C member 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1.

Function:

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.

Subcellular Location:

Isoform Beta Nucleus Localized largely in the nucleus.

Protein Attributes:

Sequence length:

777

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

777:

EMLAEIITNQ | IPKYSNGNIK | KLLFHQK

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000231509

SMR:

P04150

String:

P04150

UniGene:

Hs.122926

KEGG:

hsa:2908

Pfam:

PF02155

MIM:

138040

Uniprot:

P04150

FOR

ELISA Kit for Human GR

Cat.:

E1608h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human GR

Cat.:

E1608r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human GR

Cat.:

E1608m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human GR

Cat.:

E1608p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human GR

MSDS:

Please sign in first.

CLIA Kit for Human GR

Cat.:

U1608p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human GR

Cat.:

U1608m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human GR

MSDS:

Please sign in first.

CLIA Kit for Human GR

Cat.:

U1608r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human GR

Cat.:

U1608h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human GR

Cat.:

P1608Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human GR

Cat.:

P1608Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human GR

Cat.:

P1608Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human GR

Protein for Human GR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure and expression of a functional human glucocorticoid receptor cDNA."
Hollenberg S.M. , Weinberger C. , Ong E.S. , Cerelli G. , Oro A. , Lebo R. , Thompson E.B. , Rosenfeld M.G. , Evans R.M.
Nature318:635-641(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
tissue: Fibroblast.
2.

"The genomic structure of the human glucocorticoid receptor."
Encio I.J. , Detera-Wadleigh S.D.
J. Biol. Chem.266:7182-7188(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA AND BETA)
3.

"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
Wang W. , Shen P. , Thiyagarajan S. , Lin S. , Palm C. , Horvath R. , Klopstock T. , Cutler D. , Pique L. , Schrijver I. , Davis R.W. , Mindrinos M. , Speed T.P. , Scharfe C.
Nucleic Acids Res.39:44-58(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoform."
Turner J.D. , Schote A.B. , Keipes M. , Muller C.P.
Ann. N. Y. Acad. Sci.1095:334-341(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10)
5.

"Alternative splicing within the DNA binding domain creates a novel isoform of the human glucocorticoid receptor."
Munroe D.G. , Pang J. , Taylor G.R. , Lau C. , Plante R.K. , Zhou L.
Submitted (1993-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-2)
tissue: Osteosarcoma.
6.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
tissue: Kidney.
7.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
tissue: Uterine endothelium.
8.

NIEHS SNPs program
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-23 AND VAL-65
9.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
10.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
tissue: Placenta.
13.

"Purification of a human glucocorticoid receptor gene promoter-binding protein. Production of polyclonal antibodies against the purified factor."
Leclerc S. , Xie B.X. , Roy R. , Govindan M.V.
J. Biol. Chem.266:8711-8719(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-394
14.

"Human glucocorticoid receptor gene promotor-homologous down regulation."
Govindan M.V. , Pothier F. , Leclerc S. , Palaniswami R. , Xie B.
J. Steroid Biochem. Mol. Biol.40:317-323(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-394
15.

"Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product."
Weinberger C. , Hollenberg S.M. , Rosenfeld M.G. , Evans R.M.
Nature318:670-672(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAINS
16.

"Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells."
Moalli P.A. , Pillay S. , Krett N.L. , Rosen S.T.
Cancer Res.53:3877-3879(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS GP-P; GP-A ALPHA AND GP-A BETA)
17.

"Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor."
Henriksson A. , Almloef T. , Ford J. , McEwan I.J. , Gustafsson J.-A. , Wright A.P.H.
Mol. Cell. Biol.17:3065-3073(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TADA2L AND THE ADA COMPLEX;MUTAGENESIS OF PHE-191; ILE-193; LEU-194; LEU-197; TRP-213; LEU-224; LEU-225; PHE-235 AND LEU-236
18.

"Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex."
Fryer C.J. , Archer T.K.
Nature393:88-91(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THE SMARCA4 COMPLEX; NCOA1; NCOA2 AND THE CREBBP/EP300 COMPLEX
19.

"A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity."
Schneikert J. , Huebner S. , Martin E. , Cato A.B.C.
J. Cell Biol.146:929-940(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAG1
20.

"Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing."
Rivers C. , Levy A. , Hancock J. , Lightman S. , Norman M.
J. Clin. Endocrinol. Metab.84:4283-4286(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS ALPHA-2 AND BETA-2)
21.

"Steroidogenic enzyme gene expression in the human heart."
Kayes-Wandover K.M. , White P.C.
J. Clin. Endocrinol. Metab.85:2519-2525(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
22.

"A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."
Mahajan M.A. , Samuels H.H.
Mol. Cell. Biol.20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
23.

"Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor."
Diamond M.I. , Robinson M.R. , Yamamoto K.R.
Proc. Natl. Acad. Sci. U.S.A.97:657-661(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EFFECT ON EXPANDED POLYGLUTAMINE PROTEIN
24.

"Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids."
Wallace A.D. , Cidlowski J.A.
J. Biol. Chem.276:42714-42721(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLUCOCORTICOID-MEDIATED DOWN-REGULATION
25.

"High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids."
Strickland I. , Kisich K. , Hauk P.J. , Vottero A. , Chrousos G.P. , Klemm D.J. , Leung D.Y.M.
J. Exp. Med.193:585-593(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REDUCTION OF CELL DEATH IN RESPONSE TO CORTICOSTEROIDS
26.

"Molecular identification and characterization of A and B forms of the glucocorticoid receptor."
Yudt M.R. , Cidlowski J.A.
Mol. Endocrinol.15:1093-1103(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION;MUTAGENESIS OF MET-1 AND MET-27
27.

"Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor."
Tian S. , Poukka H. , Palvimo J.J. , Jaenne O.A.
Biochem. J.367:907-911(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;MUTAGENESIS OF LYS-277; LYS-293 AND LYS-703
28.

"Deciphering the phosphorylation 'code' of the glucocorticoid receptor in vivo."
Wang Z. , Frederick J. , Garabedian M.J.
J. Biol. Chem.277:26573-26580(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-203 AND SER-211
29.

"Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."
Wong C.-W. , McNally C. , Nickbarg E. , Komm B.S. , Cheskis B.J.
Proc. Natl. Acad. Sci. U.S.A.99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELP1
30.

"The origin and functions of multiple human glucocorticoid receptor isoforms."
Lu N.Z. , Cidlowski J.A.
Ann. N. Y. Acad. Sci.1024:102-123(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ALTERNATIVE SPLICING;ALTERNATIVE INITIATION
31.

"Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation."
Guerrero-Santoro J. , Yang L. , Stallcup M.R. , DeFranco D.B.
J. Cell. Biochem.92:810-819(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
32.

"HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b."
Shimizu N. , Ouchida R. , Yoshikawa N. , Hisada T. , Watanabe H. , Okamoto K. , Kusuhara M. , Handa H. , Morimoto C. , Tanaka H.
Proc. Natl. Acad. Sci. U.S.A.102:8555-8560(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HEXIM1
33.

"GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway."
Chadli A. , Graham J.D. , Abel M.G. , Jackson T.A. , Gordon D.F. , Wood W.M. , Felts S.J. , Horwitz K.B. , Toft D.
Mol. Cell. Biol.26:1722-1730(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UNC45A
34.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
35.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
36.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134 AND SER-267;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
37.

"Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications."
Nader N. , Chrousos G.P. , Kino T.
FASEB J.23:1572-1583(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACETYLATION AT LYS-480; LYS-492; LYS-494 AND LYS-495;MUTAGENESIS OF LYS-480; LYS-492; LYS-494 AND LYS-495;INTERACTION WITH CLOCK
38.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
39.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
40.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
41.

"Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor."
Psarra A.M. , Sekeris C.E.
Biochim. Biophys. Acta1813:1814-1821(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
42.

"The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress."
Gallo L.I. , Lagadari M. , Piwien-Pilipuk G. , Galigniana M.D.
J. Biol. Chem.286:30152-30160(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT
43.

"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Lamia K.A. , Papp S.J. , Yu R.T. , Barish G.D. , Uhlenhaut N.H. , Jonker J.W. , Downes M. , Evans R.M.
Nature480:552-556(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRY1 AND CRY2
44.

"Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man."
Charmandari E. , Chrousos G.P. , Lambrou G.I. , Pavlaki A. , Koide H. , Ng S.S. , Kino T.
PLoS ONE6:E25612-E25612(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;INTERACTION WITH CLOCK
45.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
46.

"RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity."
Druker J. , Liberman A.C. , Antunica-Noguerol M. , Gerez J. , Paez-Pereda M. , Rein T. , Iniguez-Lluhi J.A. , Holsboer F. , Arzt E.
Mol. Cell. Biol.33:2116-2127(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LYS-703
47.

"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition."
Bledsoe R.K. , Montana V.G. , Stanley T.B. , Delves C.J. , Apolito C.J. , McKee D.D. , Consler T.G. , Parks D.J. , Stewart E.L. , Willson T.M. , Lambert M.H. , Moore J.T. , Pearce K.H. , Xu H.E.
Cell110:93-105(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 521-777 OF MUTANT SER-602 IN COMPLEX WITH NCOA2; DEXAMETHASONE AND RU-486;MUTAGENESIS OF ARG-585; ASP-590; PHE-602; PRO-625 AND ILE-628
48.

"The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism."
Kauppi B. , Jakob C. , Faernegaardh M. , Yang J. , Ahola H. , Alarcon M. , Calles K. , Engstrom O. , Harlan J. , Muchmore S. , Ramqvist A.-K. , Thorell S. , Oehman L. , Greer J. , Gustafsson J.-A. , Carlstedt-Duke J. , Carlquist M.
J. Biol. Chem.278:22748-22754(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 500-777 OF MUTANT SER-602 IN COMPLEX WITH COACTIVATOR PEPTIDE; DEXAMETHASONE AND WITH RU-486
49.

"Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance."
Hurley D.M. , Accili D. , Stratakis C.A. , Karl M. , Vamvakopoulos N. , Rorer E. , Constantine K. , Taylor S.I. , Chrousos G.P.
J. Clin. Invest.87:680-686(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT GCRES VAL-641
50.

"Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells."
Powers J.H. , Hillmann A.G. , Tang D.C. , Harmon J.M.
Cancer Res.53:4059-4065(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TYR-421 AND PHE-753
51.

"Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene."
Karl M. , Lamberts S.W.J. , Detera-Wadleigh S.D. , Encio I.J. , Stratakis C.A. , Hurley D.M. , Accili D. , Chrousos G.P.
J. Clin. Endocrinol. Metab.76:683-689(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-363
52.

"A mutation of the glucocorticoid receptor in primary cortisol resistance."
Malchoff D.M. , Brufsky A. , Reardon G. , McDermott P. , Javier E.C. , Bergh C.H. , Rowe D. , Malchoff C.D.
J. Clin. Invest.91:1918-1925(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GCRES ILE-729
53.

"Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes."
Ashraf J. , Thompson E.B.
Mol. Endocrinol.7:631-642(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PHE-753
54.

"Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance."
Koper J.W. , Stolk R.P. , de Lange P. , Huizenga N.A.T.M. , Molijn G.-J. , Pols H.A.P. , Grobbee D.E. , Karl M. , de Jong F.H. , Brinkmann A.O. , Lamberts S.W.J.
Hum. Genet.99:663-668(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-23 AND SER-363
55.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-23; VAL-65 AND SER-363
56.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
57.

"Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia."
Feng J. , Zheng J. , Bennett W.P. , Heston L.L. , Jones I.R. , Craddock N. , Sommer S.S.
Am. J. Med. Genet.96:412-417(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-23; LEU-29; PHE-112; ASN-233 AND SER-363
58.

"Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance."
Ruiz M. , Lind U. , Gaafvels M. , Eggertsen G. , Carlstedt-Duke J. , Nilsson L. , Holtmann M. , Stierna P. , Wikstroem A.-C. , Werner S.
Clin. Endocrinol. (Oxf.)55:363-371(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GCRES HIS-477 AND SER-679
59.

"The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus."
Dobson M.G. , Redfern C.P.F. , Unwin N. , Weaver J.U.
J. Clin. Endocrinol. Metab.86:2270-2274(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-363
60.

"Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking."
Kino T. , Stauber R.H. , Resau J.H. , Pavlakis G.N. , Chrousos G.P.
J. Clin. Endocrinol. Metab.86:5600-5608(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT GCRES ASN-559
61.

"A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels."
van Rossum E.F.C. , Koper J.W. , Huizenga N.A.T.M. , Uitterlinden A.G. , Janssen J.A.M.J.L. , Brinkmann A.O. , Grobbee D.E. , de Jong F.H. , van Duyn C.M. , Pols H.A.P. , Lamberts S.W.J.
Diabetes51:3128-3134(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-23
62.

"Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene."
Mendonca B.B. , Leite M.V. , de Castro M. , Kino T. , Elias L.L.K. , Bachega T.A.S. , Arnhold I.J.P. , Chrousos G.P. , Latronico A.C.
J. Clin. Endocrinol. Metab.87:1805-1809(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PSEUDOHERMAPHRODITISM ALA-571
63.

"A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators."
Vottero A. , Kino T. , Combe H. , Lecomte P. , Chrousos G.P.
J. Clin. Endocrinol. Metab.87:2658-2667(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GCRES MET-747;ALTERED INTERACTION WITH THE COACTIVATOR NCOA2
64.

"Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men."
van Rossum E.F.C. , Feelders R.A. , van den Beld A.W. , Uitterlinden A.G. , Janssen J.A.M.J.L. , Ester W. , Brinkmann A.O. , Grobbee D.E. , de Jong F.H. , Pols H.A.P. , Koper J.W. , Lamberts S.W.J.
Am. J. Med.117:158-162(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-23
65.

"The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults."
van Rossum E.F.C. , Voorhoeve P.G. , te Velde S.J. , Koper J.W. , Delemarre-van de Waal H.A. , Kemper H.C.G. , Lamberts S.W.J.
J. Clin. Endocrinol. Metab.89:4004-4009(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-23

Product Feedback Wall

* Email:
*Comments: