GCSAM ELISA Kit for Human(Homo sapiens) | EIAab.comGCSAM ELISA Kit for Human(Homo sapiens)

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GCSAM (Gene name),

Germinal center-associated signaling and motility protein (Protein name ), GCSAM_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GCSAM(GAL;GCET2);

Protein name:

Germinal center-associated signaling and motility protein;

Alternative:

Germinal center-associated lymphoma protein(hGAL);Germinal center B-cell-expressed transcript 2 protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ACTB and MYH2; the interaction with MYH2 is increased by IL6-induced phosphorylation. Interacts (via C-terminus) with ARHGEF11 (via DH domain). Interacts with ARHGEF12. Interacts with SYK; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity.

Function:

Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

Subcellular Location:

Cytoplasm Cell membrane It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.

Protein Attributes:

Sequence length:

178

Sequence:

50:

100:

150:

178:

LMPHRISSHF | LQQPRPLMAP | SETQFSHL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.49614

MIM:

607792

STRING:

9606.ENSP00000309487

KEGG:

hsa:257144

Uniprot:

Q8N6F7

FOR

ELISA Kit for Human Germinal center-associated signaling and motility protein

CLIA Kit for Human Germinal center-associated signaling and motility protein

Polyclonal Antibody for Human Germinal center-associated signaling and motility protein

Monoclonal Antibody for Human Germinal center-associated signaling and motility protein

Protein for Human Germinal center-associated signaling and motility protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells."
Pan Z. , Shen Y. , Du C. , Zhou G. , Rosenwald A. , Staudt L.M. , Greiner T.C. , McKeithan T.W. , Chan W.C.
Am. J. Pathol.163:135-144(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
2.

"HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma."
Lossos I.S. , Alizadeh A.A. , Rajapaksa R. , Tibshirani R. , Levy R.
Blood101:433-440(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION;TISSUE SPECIFICITY
3.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Lymphoma.
5.

"Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation."
Natkunam Y. , Lossos I.S. , Taidi B. , Zhao S. , Lu X. , Ding F. , Hammer A.S. , Marafioti T. , Byrne G.E. Jr. , Levy S. , Warnke R.A. , Levy R.
Blood105:3979-3986(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration."
Lu X. , Chen J. , Malumbres R. , Cubedo Gil E. , Helfman D.M. , Lossos I.S.
Blood110:4268-4277(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MYH2 AND ACTB;PHOSPHORYLATION BY LYN;MUTAGENESIS OF TYR-128 AND TYR-148
7.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-148;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
8.

"HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway."
Jiang X. , Lu X. , McNamara G. , Liu X. , Cubedo E. , Sarosiek K.A. , Sanchez-Garcia I. , Helfman D.M. , Lossos I.S.
Blood116:5217-5227(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH ARHGEF11 AND ARHGEF12
9.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation."
Romero-Camarero I. , Jiang X. , Natkunam Y. , Lu X. , Vicente-Duenas C. , Gonzalez-Herrero I. , Flores T. , Garcia J.L. , McNamara G. , Kunder C. , Zhao S. , Segura V. , Fontan L. , Martinez-Climent J.A. , Garcia-Criado F.J. , Theis J.D. , Dogan A. , Campos-Sanchez E. , more...
Nat. Commun.4:1338-1338(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS REGULATOR OF B-CELL RECEPTOR SIGNALING;INTERACTION WITH SYK;SUBCELLULAR LOCATION;MUTAGENESIS OF 106-TYR-TYR-107; TYR-128 AND TYR-148

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