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Index > Protein center > GEMIN6(Gene name) > Human
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  • GEMIN6 (Gene name),
  • Gem-associated protein 6 (Protein name ),  GEMI6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GEMIN6;
    Protein name:
    Gem-associated protein 6(Gemin-6);
    Alternative:
    SIP2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN7, SNRPB, SNRPD2, SNRPD3 and SNRPE.
    Function:
    The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.
    Subcellular Location:
    Nucleus nucleoplasm Nucleus gem Cytoplasm Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
    Protein Attributes:
    Sequence length:
    167
    Sequence:
    50:
    MSEWMKKGPL | EWQDYIYKEV | RVTASEKNEY | KGWVLTTDPV | SANIVLVNFL | 
    100:
    EDGSMSVTGI | MGHAVQTVET | MNEGDHRVRE | KLMHLFTSGD | CKAYSPEDLE | 
    150:
    ERKNSLKKWL | EKNHIPITEQ | GDAPRTLCVA | GVLTIDPPYG | PENCSSSNEI | 
    167:
    ILSRVQDLIE | GHLTASQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Gemin-6
    ELISA Kit for Human Gemin-6
    ELISA Kit for Human Gemin-6
    CLIA Kit for Human Gemin-6
    CLIA Kit for Human Gemin-6
    CLIA Kit for Human Gemin-6
    Polyclonal Antibody for Human Gemin-6
    Polyclonal Antibody for Human Gemin-6
    Polyclonal Antibody for Human Gemin-6
    Monoclonal Antibody for Human Gemin-6
    Monoclonal Antibody for Human Gemin-6
    Monoclonal Antibody for Human Gemin-6
    Protein for Human Gemin-6
    Protein for Human Gemin-6
    Protein for Human Gemin-6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component."
      Pellizzoni L. , Baccon J. , Rappsilber J. , Mann M. , Dreyfuss G.
      J. Biol. Chem.277:7540-7545(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 155-167;FUNCTION;INTERACTION WITH SNRPB; SNRPD2; SNRPD3 AND SNRPE;SUBCELLULAR LOCATION
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Small intestine.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-140
      tissue: Ovary.
    6. 6.
      "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex."
      Baccon J. , Pellizzoni L. , Rappsilber J. , Mann M. , Dreyfuss G.
      J. Biol. Chem.277:31957-31962(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GEMIN7
    7. 7.
      "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
      Chari A. , Golas M.M. , Klingenhager M. , Neuenkirchen N. , Sander B. , Englbrecht C. , Sickmann A. , Stark H. , Fischer U.
      Cell135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SNRNP BIOGENESIS;IDENTIFICATION IN SMN-SM COMPLEX
    8. 8.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure."
      Ma Y. , Dostie J. , Dreyfuss G. , Van Duyne G.D.
      Structure13:883-892(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-86 IN COMPLEX WITH GEMIN7;INTERACTION WITH SNRPB; SNRPD2; SNRPD3 AND SNRPE
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