GGA3 ELISA Kit for Human(Homo sapiens) | EIAab.comGGA3 ELISA Kit for Human(Homo sapiens) | EIAab.com

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GGA3 (Gene name),

ADP-ribosylation factor-binding protein GGA3 (Protein name ), GGA3_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

GGA3(KIAA0154);

Protein name:

ADP-ribosylation factor-binding protein GGA3;

Alternative:

Golgi-localized, gamma ear-containing, ARF-binding protein 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200 (By similarity). Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC.

Function:

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Subcellular Location:

Golgi apparatus trans-Golgi network membrane Peripheral membrane protein Endosome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

723

Sequence:

50:

MAEAEGESLE | SWLNKATNPS | NRQEDWEYII | GFCDQINKEL | EGPQIAVRLL |

100:

AHKIQSPQEW | EALQALTVLE | ACMKNCGRRF | HNEVGKFRFL | NELIKVVSPK |

150:

YLGDRVSEKV | KTKVIELLYS | WTMALPEEAK | IKDAYHMLKR | QGIVQSDPPI |

200:

PVDRTLIPSP | PPRPKNPVFD | DEEKSKLLAK | LLKSKNPDDL | QEANKLIKSM |

250:

VKEDEARIQK | VTKRLHTLEE | VNNNVRLLSE | MLLHYSQEDS | SDGDRELMKE |

300:

LFDQCENKRR | TLFKLASETE | DNDNSLGDIL | QASDNLSRVI | NSYKTIIEGQ |

350:

VINGEVATLT | LPDSEGNSQC | SNQGTLIDLA | ELDTTNSLSS | VLAPAPTPPS |

400:

SGIPILPPPP | QASGPPRSRS | SSQAEATLGP | SSTSNALSWL | DEELLCLGLA |

450:

DPAPNVPPKE | SAGNSQWHLL | QREQSDLDFF | SPRPGTAACG | ASDAPLLQPS |

500:

APSSSSSQAP | LPPPFPAPVV | PASVPAPSAG | SSLFSTGVAP | ALAPKVEPAV |

550:

PGHHGLALGN | SALHHLDALD | QLLEEAKVTS | GLVKPTTSPL | IPTTTPARPL |

600:

LPFSTGPGSP | LFQPLSFQSQ | GSPPKGPELS | LASIHVPLES | IKPSSALPVT |

650:

AYDKNGFRIL | FHFAKECPPG | RPDVLVVVVS | MLNTAPLPVK | SIVLQAAVPK |

700:

SMKVKLQPPS | GTELSPFSPI | QPPAAITQVM | LLANPLKEKV | RLRYKLTFAL |

723:

GEQLSTEVGE | VDQFPPVEQW | GNL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

String:

STRING:

9606.ENSP00000245541

KEGG:

Pfam:

SMR:

MIM:

Uniprot:

FOR

ELISA Kit for Human ADP-ribosylation factor-binding protein GGA3

ELISA Kit for Human ADP-ribosylation factor-binding protein GGA3

CLIA Kit for Human ADP-ribosylation factor-binding protein GGA3

CLIA Kit for Human ADP-ribosylation factor-binding protein GGA3

Polyclonal Antibody for Human ADP-ribosylation factor-binding protein GGA3

Polyclonal Antibody for Human ADP-ribosylation factor-binding protein GGA3

Monoclonal Antibody for Human ADP-ribosylation factor-binding protein GGA3

Monoclonal Antibody for Human ADP-ribosylation factor-binding protein GGA3

Protein for Human ADP-ribosylation factor-binding protein GGA3

Protein for Human ADP-ribosylation factor-binding protein GGA3

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex."
Dell'Angelica E.C. , Puertollano R. , Mullins C. , Aguilar R.C. , Vargas J.D. , Hartnell L.M. , Bonifacino J.S.
J. Cell Biol.149:81-94(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)
tissue: Heart.
2.

"A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi."
Boman A.L. , Zhang C.-J. , Zhu X. , Kahn R.A.
Mol. Biol. Cell11:1241-1255(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
3.

"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T. , Seki N. , Tanaka A. , Ishikawa K. , Nomura N.
DNA Res.2:167-174(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT)
tissue: Bone marrow.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
tissue: Testis.
5.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT)
tissue: Brain.
8.

"Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin."
Takatsu H. , Yoshino K. , Nakayama K.
Biochem. Biophys. Res. Commun.271:719-725(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNRG
9.

"The GGAs promote ARF-dependent recruitment of clathrin to the TGN."
Puertollano R. , Randazzo P.A. , Presley J.F. , Hartnell L.M. , Bonifacino J.S.
Cell105:93-102(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-194; SER-199 AND THR-217;INTERACTION WITH ARF1 AND CLATHRIN;FUNCTION
10.

"Sorting of mannose 6-phosphate receptors mediated by the GGAs."
Puertollano R. , Aguilar R.C. , Gorshkova I. , Crouch R.J. , Bonifacino J.S.
Science292:1712-1716(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH M6PR AND IGF2R
11.

"GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors."
Takatsu H. , Yoshino K. , Toda K. , Nakayama K.
Biochem. J.365:369-378(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARF1; ARF5 AND ARF6
12.

"Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics."
Wasiak S. , Legendre-Guillemin V. , Puertollano R. , Blondeau F. , Girard M. , de Heuvel E. , Boismenu D. , Bell A.W. , Bonifacino J.S. , McPherson P.S.
J. Cell Biol.158:855-862(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPN4
13.

"Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif."
Doray B. , Bruns K. , Ghosh P. , Kornfeld S.A.
Proc. Natl. Acad. Sci. U.S.A.99:8072-8077(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 391-ASP--LEU-395;INTERACTION WITH IGF2R;AUTOINHIBITION
14.

"Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins."
He X. , Zhu G. , Koelsch G. , Rodgers K.K. , Zhang X.C. , Tang J.
Biochemistry42:12174-12180(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BACE1
15.

"Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."
Mattera R. , Arighi C.N. , Lodge R. , Zerial M. , Bonifacino J.S.
EMBO J.22:78-88(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RABEP1 AND RABGEF1
16.

"Mammalian GGAs act together to sort mannose 6-phosphate receptors."
Ghosh P. , Griffith J. , Geuze H.J. , Kornfeld S.
J. Cell Biol.163:755-766(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GGA1 AND GGA2
17.

"GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination."
Shiba Y. , Katoh Y. , Shiba T. , Yoshino K. , Takatsu H. , Kobayashi H. , Shin H.-W. , Wakatsuki S. , Nakayama K.
J. Biol. Chem.279:7105-7111(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-247; LEU-262; LEU-276; LEU-280; ASP-284 AND TYR-293;INTERACTION WITH UBC;UBIQUITINATION
18.

"Definition of the consensus motif recognized by gamma-adaptin ear domains."
Mattera R. , Ritter B. , Sidhu S.S. , McPherson P.S. , Bonifacino J.S.
J. Biol. Chem.279:8018-8028(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NECAP1; NECAP2 AND AFTPH
19.

"The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites."
Mattera R. , Puertollano R. , Smith W.J. , Bonifacino J.S.
J. Biol. Chem.279:31409-31418(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LYS-258 AND SER-283;INTERACTION WITH RABEP1
20.

"Interactions of GGA3 with the ubiquitin sorting machinery."
Puertollano R. , Bonifacino J.S.
Nat. Cell Biol.6:244-251(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF LEU-276;INTERACTION WITH UBC AND TSG101
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism."
Kato Y. , Misra S. , Puertollano R. , Hurley J.H. , Bonifacino J.S.
Nat. Struct. Biol.9:532-536(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-166
23.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-574

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