Protein name:
Zinc finger protein GLI1 ;
Alternative:
Glioma-associated oncogene homolog ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ZIC1; the interaction enhances transcription activation (By similarity). Interacts with KIF7.
Function:
Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
Subcellular Location:
Cytoplasm
Nucleus
Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.
Protein Attributes:
50:
MFNPMTPPQV | NSYSEPCCLR | PLHSQGVPSM | GTEGLSGLPF | CHQANFMSGS |
100:
QGYGAARETS | SCTEGSLFPP | PPPPRSSVKL | TKKRALSISP | LSDASLDLQT |
150:
VIRTSPSSLV | AFINSRCTSP | GGSYGHLSIG | TMSPSLGFPP | QMSHQKGTSP |
200:
PYGVQPCVPH | DSTRGSMMLH | PQARGPRATC | QLKSELDMMV | GKCPEDPLEG |
250:
DMSSPNSTGI | QDHLLGMLDG | REDLEREEKP | EPESVYETDC | RWDGCSQEFD |
300:
SQEQLVHHIN | SEHIHGERKE | FVCHWGGCSR | ELRPFKAQYM | LVVHMRRHTG |
350:
EKPHKCTFEG | CRKSYSRLEN | LKTHLRSHTG | EKPYMCEQEG | CSKAFSNASD |
400:
RAKHQNRTHS | NEKPYVCKLP | GCTKRYTDPS | SLRKHVKTVH | GPDAHVTKRH |
450:
RGDGPLPRAQ | PLSTVEPKRE | REGGSGREES | RLTVPESAMP | QQSPGAQSSC |
500:
SSDHSPAGSA | ANTDSGVEMA | GNAGGSTEDL | SSLDEGPCVS | ATGLSTLRRL |
550:
ENLRLDQLHQ | LRPIGSRGLK | LPSLTHAGAP | VSRRLGPPVS | LDRRSSSSSS |
600:
MSSAYTVSRR | SSLASPFPPG | TPPENGASSL | PGLTPAQHYM | LRARYASARG |
650:
SGTPPTAAHS | LDRMGGLSVP | PWRSRTEYPG | YNPNAGVTRR | ASDPARAADH |
700:
PAPARVQRFK | SLGCVHTPPS | VATGRNFDPH | HPTSVYSPQP | PSITENVAMD |
750:
TRGLQEEPEV | GTSVMGNGLN | PYMDFSSTDT | LGYGGPEGTA | AEPYEARGPG |
800:
SLPLGPGPPT | NYGPGHCAQQ | VSYPDPTPEN | WGEFPSHAGV | YPSNKAPGAA |
850:
YSQCPRLEHY | GQVQVKPEQG | CPVGSDSTGL | APCLNAHPSE | GSPGPQPLFS |
900:
HHPQLPQPQY | PQSGPYPQPP | HGYLSTEPRL | GLNFNPSSSH | STGQLKAQLV |
950:
CNYVQSQQEL | LWEGRNRGGL | PNQELPYQSP | KFLGGSQVSQ | SPAKTPAAAA |
1000:
AAYGSGFAPA | SANHKSGSYP | APSPCHETFT | VGVNRPSHRP | AAPPRLLPPL |
1050:
SPCYGPLKVG | DTNPSCGHPE | VGRLGAGPAL | YPPPEGQVCN | ALDSLDLDNT |
1100:
QLDFVAILDE | AQGLSPPLSH | EQGDSSKNTP | SPSGPPNMAV | GNMSVLLGSL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Chicken
ELISA Kit for Mouse Zinc finger protein GLI1
ELISA Kit for Mouse Zinc finger protein GLI1
ELISA Kit for Mouse Zinc finger protein GLI1
CLIA Kit for Mouse Zinc finger protein GLI1
CLIA Kit for Mouse Zinc finger protein GLI1
CLIA Kit for Mouse Zinc finger protein GLI1
Polyclonal Antibody for Mouse Zinc finger protein GLI1
Polyclonal Antibody for Mouse Zinc finger protein GLI1
Polyclonal Antibody for Mouse Zinc finger protein GLI1
Monoclonal Antibody for Mouse Zinc finger protein GLI1
Monoclonal Antibody for Mouse Zinc finger protein GLI1
Monoclonal Antibody for Mouse Zinc finger protein GLI1
Protein for Mouse Zinc finger protein GLI1
Protein for Mouse Zinc finger protein GLI1
Protein for Mouse Zinc finger protein GLI1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
ICR .
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
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Goodstadt L.
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Hillier L.W.
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Zody M.C.
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Goldstein S.
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She X.
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 272-837
strain :
CD-1 .
tissue :
Embryo .
6.
"The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."
Endoh-Yamagami S.
,
Evangelista M.
,
Wilson D.
,
Wen X.
,
Theunissen J.W.
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Phamluong K.
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Peterson A.S.
Curr. Biol.19:1320-1326(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KIF7