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Index > Protein center > Gprc6a(Gene name) > Mouse
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  • Gprc6a (Gene name),
  • G-protein coupled receptor family C group 6 member A (Protein name ),  GPC6A_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Gprc6a;
    Protein name:
    G-protein coupled receptor family C group 6 member A;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritionnal and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    928
    Sequence:
    50:
    MALLITVVTC | FMIILDTSQS | CHTPDDFVAI | TSPGHIMIGG | LFAIHEKMLS | 
    100:
    SDDHPRRPQI | QKCAGFEISV | FLQTLAMIHS | IEMINNSTLL | SGVKLGYEIY | 
    150:
    DTCTEVTAAM | AATLRFLSKF | NCSRETVVFQ | CDYSSYMPRV | KAVIGAGYSE | 
    200:
    TSIAVSRMLN | LQLMPQVSYE | STAEILSDKI | RFPSFLRTVP | SDFYQTKAMA | 
    250:
    HLIRQSGWNW | IGAITTDDDY | GRLALNTFAI | QAAENNVCIA | FKEVLPAFLS | 
    300:
    DNTIEVRINQ | TLEKIIAEAQ | VNVIVVFLRK | FHVFNLFTKA | IERKISKIWI | 
    350:
    ASDNWSTATK | IITIPNVKKL | GKVVGFAFRR | GNTSSFHSFL | QTLHMYPNDN | 
    400:
    NKPLHEFAML | VSACKYIKDG | DLSQCISNYS | QATLTYDTTK | TIENHLFKRN | 
    450:
    DFLWHYTEPG | LIYSIQLAVF | ALGHAIRDLC | QARDCKKPNA | FQPWELLAVL | 
    500:
    KNVTFTDGRN | SFHFDAHGDL | NTGYDVVLWK | ETNGLMTVTK | MAEYDLQRDV | 
    550:
    FITTNQETKH | EFRKLKQILS | KCSKECSPGQ | MKKATGSQHS | CCYECVSCPE | 
    600:
    NHYSNETDMD | HCLLCNNETH | WAPVRSTTCF | EKEVEYLDWD | DSLALLLIAL | 
    650:
    SLLGIAFVLA | IGIIFTRNLK | TPVVKSSGGL | VVCYVMLICH | ALNFASTGFF | 
    700:
    IGEPQDFACK | TRQTLFGVSF | TLCVSCILTK | SLKILLAFSF | DPKLTMFLKC | 
    750:
    LYRPVPIVLT | CTGIQVVICT | LWLVLAAPSV | EENISLPRVI | ILECEEGSAL | 
    800:
    AFGTMLGYIT | VLAFICFVFA | FKGRKLPENY | NEAKFLTFGM | LIYFIAWITF | 
    850:
    IPVYTTTFGK | YLPAVEIIVI | LISNYGILCC | IFFPKCYIIL | CKQKTNTKSA | 
    900:
    FLQMVYNYSA | HSVDSLALSH | VSLDSTSYDT | ATTNQSPGNK | MTACQNDNHL | 
    928:
    PAQVLPHTGT | AKTIKASKTL | RQKRSSSI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    E6430h
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    96T
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    ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    E6430r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    E6430b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    E6430m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    U6430h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    U6430b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    U6430m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    U6430r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    P6430Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    P6430Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Cat.:
    P6430Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
    Protein for Mouse G-protein coupled receptor family C group 6 member A
    Protein for Mouse G-protein coupled receptor family C group 6 member A
    Protein for Mouse G-protein coupled receptor family C group 6 member A
    Protein for Mouse G-protein coupled receptor family C group 6 member A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of a family C orphan G-protein coupled receptor."
      Kuang D. , Yao Y. , Lam J. , Tsushima R.G. , Hampson D.R.
      J. Neurochem.93:383-391(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);SUBCELLULAR LOCATION;SUBUNIT;GLYCOSYLATION;TISSUE SPECIFICITY
      strain: CD-1.
    2. 2.
      "Cloning of a metabotropic glutamate/pheromone receptor (Gprc6a)."
      Lorenz-Depiereux B. , Dorner M. , Strom T.M.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Swiss Webster / NIH.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids."
      Wellendorph P. , Hansen K.B. , Balsgaard A. , Greenwood J.R. , Egebjerg J. , Brauener-Osborne H.
      Mol. Pharmacol.67:589-597(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Identification of a novel extracellular cation-sensing G-protein-coupled receptor."
      Pi M. , Faber P. , Ekema G. , Jackson P.D. , Ting A. , Wang N. , Fontilla-Poole M. , Mays R.W. , Brunden K.R. , Harrington J.J. , Quarles L.D.
      J. Biol. Chem.280:40201-40209(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    6. 6.
      "GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome."
      Pi M. , Chen L. , Huang M.Z. , Zhu W. , Ringhofer B. , Luo J. , Christenson L. , Li B. , Zhang J. , Jackson P.D. , Faber P. , Brunden K.R. , Harrington J.J. , Quarles L.D.
      PLoS ONE3:E3858-E3858(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "GPRC6A mediates the non-genomic effects of steroids."
      Pi M. , Parrill A.L. , Quarles L.D.
      J. Biol. Chem.285:39953-39964(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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