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Index > Protein center > GPD1L(Gene name) > Human
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  • GPD1L (Gene name),
  • Glycerol-3-phosphate dehydrogenase 1-like protein (Protein name ),  GPD1L_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GPD1L(KIAA0089);
    Protein name:
    Glycerol-3-phosphate dehydrogenase 1-like protein(GPD1-L);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SCN5A.
    Function:
    Play a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
    Subcellular Location:
    Cytoplasm Localized to the region of the plasma membrane.
    Protein Attributes:
    Sequence length:
    351
    Sequence:
    50:
    MAAAPLKVCI | VGSGNWGSAV | AKIIGNNVKK | LQKFASTVKM | WVFEETVNGR | 
    100:
    KLTDIINNDH | ENVKYLPGHK | LPENVVAMSN | LSEAVQDADL | LVFVIPHQFI | 
    150:
    HRICDEITGR | VPKKALGITL | IKGIDEGPEG | LKLISDIIRE | KMGIDISVLM | 
    200:
    GANIANEVAA | EKFCETTIGS | KVMENGLLFK | ELLQTPNFRI | TVVDDADTVE | 
    250:
    LCGALKNIVA | VGAGFCDGLR | CGDNTKAAVI | RLGLMEMIAF | ARIFCKGQVS | 
    300:
    TATFLESCGV | ADLITTCYGG | RNRRVAEAFA | RTGKTIEELE | KEMLNGQKLQ | 
    350:
    GPQTSAEVYR | ILKQKGLLDK | FPLFTAVYQI | CYESRPVQEM | LSCLQSHPEH | 
    351:
    T
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human GPD1-L
    ELISA Kit for Human GPD1-L
    CLIA Kit for Human GPD1-L
    CLIA Kit for Human GPD1-L
    Polyclonal Antibody for Human GPD1-L
    Polyclonal Antibody for Human GPD1-L
    Monoclonal Antibody for Human GPD1-L
    Monoclonal Antibody for Human GPD1-L
    Protein for Human GPD1-L
    Protein for Human GPD1-L

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Miyajima N. , Tanaka A. , Sazuka T. , Seki N. , Sato S. , Tabata S. , Ishikawa K. , Kawarabayasi Y. , Kotani H. , Nomura N.
      DNA Res.2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Placenta.
    5. 5.
      "GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A."
      Valdivia C.R. , Ueda K. , Ackerman M.J. , Makielski J.C.
      Am. J. Physiol.297:H1446-H1452(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANTS LYS-83 AND VAL-280;INTERACTION WITH SCN5A
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANT VAL-280
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein."
      Structural genomics consortium (SGC)
      Submitted (2007-05) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 1-349 IN COMPLEX WITH NAD AND PHOSPHATE IONS
    9. 9.
      "Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome."
      Van Norstrand D.W. , Valdivia C.R. , Tester D.J. , Ueda K. , London B. , Makielski J.C. , Ackerman M.J.
      Circulation116:2253-2259(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SIDS LYS-83; VAL-124 AND CYS-273;CHARACTERIZATION OF VARIANTS SIDS LYS-83; VAL-124 AND CYS-273
    10. 10.
      "Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias."
      London B. , Michalec M. , Mehdi H. , Zhu X. , Kerchner L. , Sanyal S. , Viswanathan P.C. , Pfahnl A.E. , Shang L.L. , Madhusudanan M. , Baty C.J. , Lagana S. , Aleong R. , Gutmann R. , Ackerman M.J. , McNamara D.M. , Weiss R. , Dudley S.C. Jr.
      Circulation116:2260-2268(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;VARIANT BRGDA2 VAL-280;CHARACTERIZATION OF VARIANT BRGDA2 VAL-280
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