GPSM1 ELISA Kit for Human(Homo sapiens) | EIAab.comGPSM1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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GPSM1 (Gene name),

G-protein-signaling modulator 1 (Protein name ), GPSM1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

GPSM1(AGS3);

Protein name:

G-protein-signaling modulator 1;

Alternative:

Activator of G-protein signaling 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1.

Function:

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Subcellular Location:

Cytoplasm cytosol Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side Cell membrane Peripheral membrane protein Cytoplasmic side

Protein Attributes:

Sequence length:

675

Sequence:

50:

MAGPAPPVAD | ELPGPAARRL | YSRMEASCLE | LALEGERLCK | AGDFKTGVAF |

100:

FEAAVQVGTE | DLKTLSAIYS | QLGNAYFYLK | EHGRALEYHK | HDLLLARTIG |

150:

DRMGEAKASG | NLGNTLKVLG | RFDEAAVCCQ | RHLSIAQEQG | DKVGEARALY |

200:

NIGNVYHAKG | KQLSWNAANA | TQDPGHLPPD | VRETLCKASE | FYERNLSLVK |

250:

ELGDRAAQGR | AYGNLGNTHY | LLGNFTEATT | FHKERLAIAK | EFGDKAAERR |

300:

AYSNLGNAHV | FLGRFDVAAE | YYKKTLQLSR | QLRDQAVEAQ | ACYSLGNTYT |

350:

LLQDYERAAE | YHLRHLLIAQ | ELADRVGEGR | ACWSLGNAYV | SMGRPAQALT |

400:

FAKKHLQISQ | EIGDRHGELT | ARMNVAQLQL | VLGRLTSPAA | SEKPDLAGYE |

450:

AQGARPKRTQ | RLSAETWDLL | RLPLEREQNG | DSHHSGDWRG | PSRDSLPLPV |

500:

RSRKYQEGPD | AERRPREGSH | SPLDSADVRV | HVPRTSIPRA | PSSDEECFFD |

550:

LLTKFQSSRM | DDQRCPLDDG | QAGAAEATAA | PTLEDRIAQP | SMTASPQTEE |

600:

FFDLIASSQS | RRLDDQRASV | GSLPGLRITH | SNAGHLRGHG | EPQEPGDDFF |

650:

NMLIKYQSSR | IDDQRCPPPD | VLPRGPTMPD | EDFFSLIQRV | QAKRMDEQRV |

675:

DLAGGPEQGA | GGPPEPQQQC | QPGAS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

String:

MIM:

STRING:

9606.ENSP00000392828

KEGG:

Pfam:

SMR:

UniGene:

Uniprot:

FOR

ELISA Kit for Human G-protein-signaling modulator 1

ELISA Kit for Human G-protein-signaling modulator 1

ELISA Kit for Human G-protein-signaling modulator 1

CLIA Kit for Human G-protein-signaling modulator 1

CLIA Kit for Human G-protein-signaling modulator 1

CLIA Kit for Human G-protein-signaling modulator 1

Polyclonal Antibody for Human G-protein-signaling modulator 1

Polyclonal Antibody for Human G-protein-signaling modulator 1

Polyclonal Antibody for Human G-protein-signaling modulator 1

Monoclonal Antibody for Human G-protein-signaling modulator 1

Monoclonal Antibody for Human G-protein-signaling modulator 1

Monoclonal Antibody for Human G-protein-signaling modulator 1

Protein for Human G-protein-signaling modulator 1

Protein for Human G-protein-signaling modulator 1

Protein for Human G-protein-signaling modulator 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Cismowski M.J. , Kopatz S.A. , Puhl H.L. III , Sharma S.V. , Aronstam R.S.
Submitted (2002-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Brain.
2.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue: Fetal brain.
tissue: Rhabdomyosarcoma.
5.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-675 (ISOFORM 1)
tissue: Mammary cancer.
6.

"AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin."
Natochin M. , Lester B. , Peterson Y.K. , Bernard M.L. , Lanier S.M. , Artemyev N.O.
J. Biol. Chem.275:40981-40985(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells."
Pattingre S. , de Vries L. , Bauvy C. , Chantret I. , Cluzeaud F. , Ogier-Denis E. , Vandewalle A. , Codogno P.
J. Biol. Chem.278:20995-21002(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;ALTERNATIVE SPLICING;SUBCELLULAR LOCATION
8.

"Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3."
Izaki T. , Kamakura S. , Kohjima M. , Sumimoto H.
Biochem. Biophys. Res. Commun.341:1001-1006(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INSC
9.

"The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins."
An N. , Blumer J.B. , Bernard M.L. , Lanier S.M.
J. Biol. Chem.283:24718-24728(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FRMPD1;SUBCELLULAR LOCATION
10.

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: T-cell.
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-471; SER-492 AND SER-493;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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