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Index > Protein center > Grb10(Gene name) > Mouse
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  • Grb10 (Gene name),
  • Growth factor receptor-bound protein 10 (Protein name ),  GRB10_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Grb10(Meg1);
    Protein name:
    Growth factor receptor-bound protein 10;
    Alternative:
    Maternally expressed gene 1 protein;GRB10 adapter protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain. Poorly binds to the EGFR. Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex (By similarity). Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15. When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6. Binds to activated NRAS.
    Function:
    Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
    Subcellular Location:
    Cytoplasm When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R before the sorting of the receptor to the lysosomal compartment.
    Protein Attributes:
    Sequence length:
    621
    Sequence:
    50:
    MNNDINSSVE | SLNSACNMQS | DTDTAPLLED | GQHASNQGAA | SSSRGQPQAS | 
    100:
    PRQKMQRSQP | VHILRRLQEE | DQQLRTASLP | AIPNPFPELT | GAAPGSPPSV | 
    150:
    APSSLPPPPS | QPPAKHCGRC | EKWIPGENTR | GNGKRKIWRW | QFPPGFQLSK | 
    200:
    LTRPGLWTKT | TARFSKKQPK | NQCPTDTVNP | VARMPTSQME | KLRLRKDVKV | 
    250:
    FSEDGTSKVV | EILTDMTARD | LCQLLVYKSH | CVDDNSWTLV | EHHPQLGLER | 
    300:
    CLEDHEIVVQ | VESTMPSESK | FLFRKNYAKY | EFFKNPVNFF | PDQMVNWCQQ | 
    350:
    SNGGQAQLLQ | NFLNTSSCPE | IQGFLQVKEV | GRKSWKKLYV | CLRRSGLYYS | 
    400:
    TKGTSKEPRH | LQLLADLEES | SIFYLIAGKK | QYNAPNEHGM | CIKPNKAKTE | 
    450:
    MKELRLLCAE | DEQIRTCWMT | AFRLLKYGML | LYQNYRIPQR | KGLPPPFNAP | 
    500:
    MRSVSENSLV | AMDFSGQIGR | VIDNPAEAQS | AALEEGHAWR | KRSTRMNILS | 
    550:
    SQSPLHPSTL | NAVIHRTQHW | FHGRISREES | HRIIKQQGLV | DGLFLLRDSQ | 
    600:
    SNPKAFVLTL | CHHQKIKNFQ | ILPCEDDGQT | FFTLDDGNTK | FSDLIQLVDF | 
    621:
    YQLNKGVLPC | KLKHHCIRVA | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Growth factor receptor-bound protein 10
    ELISA Kit for Mouse Growth factor receptor-bound protein 10
    ELISA Kit for Mouse Growth factor receptor-bound protein 10
    ELISA Kit for Mouse Growth factor receptor-bound protein 10
    CLIA Kit for Mouse Growth factor receptor-bound protein 10
    CLIA Kit for Mouse Growth factor receptor-bound protein 10
    CLIA Kit for Mouse Growth factor receptor-bound protein 10
    CLIA Kit for Mouse Growth factor receptor-bound protein 10
    Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
    Protein for Mouse Growth factor receptor-bound protein 10
    Protein for Mouse Growth factor receptor-bound protein 10
    Protein for Mouse Growth factor receptor-bound protein 10
    Protein for Mouse Growth factor receptor-bound protein 10

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    References
    1. 1.
      "The cloning of Grb10 reveals a new family of SH2 domain proteins."
      Ooi J. , Yajnik V. , Immanuel D. , Gordon M. , Moskow J.J. , Buchberg A. , Margolis B.
      Oncogene10:1621-1630(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH EGFR;TISSUE SPECIFICITY;PHOSPHORYLATION
      strain: Swiss.
    2. 2.
      "The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts."
      Laviola L. , Giorgino F. , Chow J.C. , Baquero J.A. , Hansen H. , Ooi J. , Zhu J. , Riedel H. , Smith R.J.
      J. Clin. Invest.99:830-837(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH INSR AND IGF1R;TISSUE SPECIFICITY
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Embryonic head.
    4. 4.
      Griffiths C. , Sycamore N.
      Submitted (2004-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Eye.
      tissue: Olfactory epithelium.
    6. 6.
      "Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene."
      Miyoshi N. , Kuroiwa Y. , Kohda T. , Shitara H. , Yonekawa H. , Kawabe T. , Hasegawa H. , Barton S.C. , Surani M.A. , Kaneko-Ishino T. , Ishino F.
      Proc. Natl. Acad. Sci. U.S.A.95:1102-1107(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IMPRINTING;DEVELOPMENTAL STAGE
    7. 7.
      "Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis."
      Wang J. , Dai H. , Yousaf N. , Moussaif M. , Deng Y. , Boufelliga A. , Swamy O.R. , Leone M.E. , Riedel H.
      Mol. Cell. Biol.19:6217-6228(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR1; INSR; IGF1R; MET AND PDGFRB
    8. 8.
      "Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion."
      Blagitko N. , Mergenthaler S. , Schulz U. , Wollmann H.A. , Craigen W. , Eggermann T. , Ropers H.-H. , Kalscheuer V.M.
      Hum. Mol. Genet.9:1587-1595(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IMPRINTING
    9. 9.
      "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling."
      Giovannone B. , Lee E. , Laviola L. , Giorgino F. , Cleveland K.A. , Smith R.J.
      J. Biol. Chem.278:31564-31573(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GIGYF1 AND GIGYF2
    10. 10.
      "The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor."
      Vecchione A. , Marchese A. , Henry P. , Rotin D. , Morrione A.
      Mol. Cell. Biol.23:3363-3372(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IGF1R AND NEDD4
    11. 11.
      "Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism."
      Charalambous M. , Smith F.M. , Bennett W.R. , Crew T.E. , Mackenzie F. , Ward A.
      Proc. Natl. Acad. Sci. U.S.A.100:8292-8297(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;IMPRINTING;DEVELOPMENTAL STAGE
    12. 12.
      "Phosphoproteomic analysis of the developing mouse brain."
      Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
      Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic brain.
    13. 13.
      "Phosphorylation of grb10 regulates its interaction with 14-3-3."
      Urschel S. , Bassermann F. , Bai R.Y. , Munch S. , Peschel C. , Duyster J.
      J. Biol. Chem.280:16987-16993(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKT1 AND YWHAE;PHOSPHORYLATION
    14. 14.
      "Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling."
      Mori K. , Giovannone B. , Smith R.J.
      Mol. Cell. Endocrinol.230:39-50(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH INSR
    15. 15.
      "GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway."
      Tezuka N. , Brown A.M. , Yanagawa S.
      Biochem. Biophys. Res. Commun.356:648-654(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LRP6
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    17. 17.
      "Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization."
      Monami G. , Emiliozzi V. , Morrione A.
      J. Cell. Physiol.216:426-437(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
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