Protein name:
Growth factor receptor-bound protein 10 ;
Alternative:
Maternally expressed gene 1 protein ;GRB10 adapter protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain. Poorly binds to the EGFR. Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex (By similarity). Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15. When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6. Binds to activated NRAS.
Function:
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Subcellular Location:
Cytoplasm
When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R before the sorting of the receptor to the lysosomal compartment.
Protein Attributes:
50:
MNNDINSSVE | SLNSACNMQS | DTDTAPLLED | GQHASNQGAA | SSSRGQPQAS |
100:
PRQKMQRSQP | VHILRRLQEE | DQQLRTASLP | AIPNPFPELT | GAAPGSPPSV |
150:
APSSLPPPPS | QPPAKHCGRC | EKWIPGENTR | GNGKRKIWRW | QFPPGFQLSK |
200:
LTRPGLWTKT | TARFSKKQPK | NQCPTDTVNP | VARMPTSQME | KLRLRKDVKV |
250:
FSEDGTSKVV | EILTDMTARD | LCQLLVYKSH | CVDDNSWTLV | EHHPQLGLER |
300:
CLEDHEIVVQ | VESTMPSESK | FLFRKNYAKY | EFFKNPVNFF | PDQMVNWCQQ |
350:
SNGGQAQLLQ | NFLNTSSCPE | IQGFLQVKEV | GRKSWKKLYV | CLRRSGLYYS |
400:
TKGTSKEPRH | LQLLADLEES | SIFYLIAGKK | QYNAPNEHGM | CIKPNKAKTE |
450:
MKELRLLCAE | DEQIRTCWMT | AFRLLKYGML | LYQNYRIPQR | KGLPPPFNAP |
500:
MRSVSENSLV | AMDFSGQIGR | VIDNPAEAQS | AALEEGHAWR | KRSTRMNILS |
550:
SQSPLHPSTL | NAVIHRTQHW | FHGRISREES | HRIIKQQGLV | DGLFLLRDSQ |
600:
SNPKAFVLTL | CHHQKIKNFQ | ILPCEDDGQT | FFTLDDGNTK | FSDLIQLVDF |
621:
YQLNKGVLPC | KLKHHCIRVA | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Pig
Human
ELISA Kit for Mouse Growth factor receptor-bound protein 10
ELISA Kit for Mouse Growth factor receptor-bound protein 10
ELISA Kit for Mouse Growth factor receptor-bound protein 10
ELISA Kit for Mouse Growth factor receptor-bound protein 10
CLIA Kit for Mouse Growth factor receptor-bound protein 10
CLIA Kit for Mouse Growth factor receptor-bound protein 10
CLIA Kit for Mouse Growth factor receptor-bound protein 10
CLIA Kit for Mouse Growth factor receptor-bound protein 10
Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
Polyclonal Antibody for Mouse Growth factor receptor-bound protein 10
Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
Monoclonal Antibody for Mouse Growth factor receptor-bound protein 10
Protein for Mouse Growth factor receptor-bound protein 10
Protein for Mouse Growth factor receptor-bound protein 10
Protein for Mouse Growth factor receptor-bound protein 10
Protein for Mouse Growth factor receptor-bound protein 10
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH INSR AND IGF1R;TISSUE SPECIFICITY
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Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
C57BL/6J .
tissue :
Embryo .
tissue :
Embryonic head .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue :
Eye .
tissue :
Olfactory epithelium .
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IMPRINTING;DEVELOPMENTAL STAGE
7.
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR1; INSR; IGF1R; MET AND PDGFRB
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IMPRINTING
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GIGYF1 AND GIGYF2
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH IGF1R AND NEDD4
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE;IMPRINTING;DEVELOPMENTAL STAGE
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic brain .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AKT1 AND YWHAE;PHOSPHORYLATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH INSR
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH LRP6
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION