Ccdc88a ELISA Kit for Mouse(Mus musculus) | EIAab.comCcdc88a ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Ccdc88a (Gene name),

Girdin (Protein name ), GRDN_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Ccdc88a(Grdn;Kiaa1212);

Protein name:

Girdin;

Alternative:

Coiled-coil domain-containing protein 88A;Akt phosphorylation enhancer(APE);Girders of actin filament;G alpha-interacting vesicle-associated protein(GIV);Hook-related protein 1(HkRP1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [Pi(4)P] and weakly with phosphatidylinositol 3-phosphate [Pi(3)P] (By similarity). Interacts with microtubules. Interacts AKT1/PKB (via C-terminus). Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1.

Function:

Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation.

Subcellular Location:

Membrane Cell membrane Cytoplasm cytosol Cytoplasmic vesicle Cell projection lamellipodium Localizes to the cell membrane through interaction with phosphoinositides.

Protein Attributes:

Sequence length:

1873

Sequence:

50:

MENEIFTPLL | EQFMTSPLVT | WVKTFGPLAA | GNGTNLDEYV | ALVDGVFLNQ |

100:

VMLQINPKSE | SQRVNKKVNN | DASLRIHNLS | ILVKQIKFYY | QETLQQLIMM |

150:

PLPDILIIGK | NPFSEQGTEE | VKKLLLLLLG | CAVQCQKKEE | FIEKIQGLDF |

200:

DTKAAVAAHI | QEVTHNQENV | FDLQWMEVTD | MSQEDIEPLL | KNMVSHLRRL |

250:

IDERDEHSET | IVELSEERDG | VHFLPHASSS | AQSPCGSPGM | KRTESRQHLS |

300:

VELADAKAKI | RRLRQELEEK | TEQLLDCKQE | LEQIEVELKR | LQQENMNLLS |

350:

DARSARMYRD | ELDALREKAV | RVDKLESELS | RYKERLHDIE | FYKARVEELK |

400:

EDNQVLLETK | TMLEDQLEGT | RARSDKLHEL | EKENLQLKAK | LHDMEMERDM |

450:

DRKKIEELME | ENMTLEMAQK | QSMDESLHLG | WELEQISRTS | ELAEAPQKSL |

500:

GHEVNELTSS | KLLKLEMENQ | SLTKTVEELR | STADSAAGST | SKILKVEKEN |

550:

QRLNKKVEIL | ENEIIQEKQS | LQNCQNLSKD | LMKEKAQLEK | TIETLRENSE |

600:

RQIKILEQEN | EHLNQTVSSL | RQRSQISAEA | RVKDIEKENK | ILHESIKETC |

650:

GKLSKIEFEK | RQMKKELELY | KEKGERAEEL | ENELNHLGKE | NELLQKKITN |

700:

LKITCEKLET | LEQENSELER | ENRKFKKTLD | SFKNLTFQLE | SLEKENSQLD |

750:

EENLELRRSV | ESLKCASMRM | AQLQLENKEL | ESEKEQLRKG | LELMRASFKK |

800:

TERLEVSYQG | LDTENQRLQK | ALENSNKKIQ | QLESELQDLE | MENQTLQKSL |

850:

EELKISSKRL | EQLEKENKSL | EQETSQLEKD | KKQLEKENKR | LRQQAEIKDT |

900:

TLEENNVKIG | NLEKENKTLF | KEINVYKESC | VRLKELEKEN | KELVKRATID |

950:

IKTLVTLRED | LVSEKLKTQQ | MNNDLEKLTH | ELEKIGLNKE | RLLHDEQSTD |

1000:

DSRYKLLESK | LESTLKKSLE | IKEEKIAALE | ARLEESTNYN | QQLRHELKTV |

1050:

KKNYEALKQR | QDEERMVQSS | IPVSGEDDKW | GRESQEATRE | LLKVKDRLIE |

1100:

VERNNATLQA | EKQALKTQLK | QLETQNNNLQ | AQILALQRQT | VSLQEQNTTL |

1150:

QTQNAKLQVE | NSTLNSQSTS | LMNQNAQLLI | QQSSLENENE | SIMKEREDLK |

1200:

SLYDALIKDH | EKLELLHERQ | ASEYESLISK | HGTLKSAHKN | LEVEHKDLED |

1250:

RYNQLLKQKG | QLEDLEKMIK | TEQEKMLLES | KNHEVVASEY | KKLCGENDRL |

1300:

NYTYSQLLKE | TEILQMDHKN | LKSVLNNSKL | EQTRLEAEFS | KLKEQYQQLD |

1350:

ITSTKLNNQC | ELLSQLKGNL | EEENRHLLDQ | IQTLMLQNRT | LLEQNMESKD |

1400:

LFHVEQRQYI | DKLNELRRQK | EKLEEKIMDQ | YKFYDPSPPR | RRGNWITLKM |

1450:

RKLIKSKKDI | NRERQKSLTL | TPTRSDSSEG | FLQLPHQDSQ | DSSSVGSNSL |

1500:

EDGQTLGTKK | SSMVALKRLP | FLRNRPKDKD | KMKACYRRSM | SMNDLVQSMV |

1550:

LAGGQWTGST | ENLEVPDDIS | TGKRRKELGA | MAFSTTAINF | STVNSSAAFR |

1600:

SKQLVNNKDT | TSFEDISPQG | ISDDSSTGSR | VHASRPASLD | SGRTSTSNSN |

1650:

NNASLHEVKA | GAVNIQSRPQ | SHSSGDFSLL | HDHETWSSSG | SSPIQYLKRQ |

1700:

TRSSPMLQHK | ISETIESRAH | HKMKAGSPGS | EVVTLQQFLE | ESNKLTSIQL |

1750:

KSSSQENLLD | EVMKSLSVSS | DFLGKDKPVS | CTLARSVSGK | TPGDFYDRRT |

1800:

TKPEFLRTGP | QKTEDAYTIS | SAGKPTPSTQ | GKIKLVKETS | VSRQSKDSNP |

1850:

YATLPRASSV | ISTAEGTTRR | TSIHDFLSKD | SRLPVSVDSS | PPTAGSSSTT |

1873:

ASNVNKVQES | RNSKSRSREQ | QSS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

Pfam:

KEGG:

UniGene:

String:

Uniprot:

FOR

ELISA Kit for Mouse Girdin

ELISA Kit for Mouse Girdin

CLIA Kit for Mouse Girdin

CLIA Kit for Mouse Girdin

Polyclonal Antibody for Mouse Girdin

Polyclonal Antibody for Mouse Girdin

Monoclonal Antibody for Mouse Girdin

Monoclonal Antibody for Mouse Girdin

Protein for Mouse Girdin

Protein for Mouse Girdin

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis."
Anai M. , Shojima N. , Katagiri H. , Ogihara T. , Sakoda H. , Onishi Y. , Ono H. , Fujishiro M. , Fukushima Y. , Horike N. , Viana A. , Kikuchi M. , Noguchi N. , Takahashi S. , Takata K. , Oka Y. , Uchijima Y. , Kurihara H. , more...
J. Biol. Chem.280:18525-18535(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH AKT1;TISSUE SPECIFICITY
tissue: Embryo.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1086-1873 (ISOFORMS 2/3)
strain: C57BL/6.
tissue: Retina.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1623-1873
strain: C57BL/6J.
tissue: Embryonic stem cell.
5.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
6.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.

"A novel hook-related protein family and the characterization of hook-related protein 1."
Simpson F. , Martin S. , Evans T.M. , Kerr M. , James D.E. , Parton R.G. , Teasdale R.D. , Wicking C.
Traffic6:442-458(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
8.

"Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways."
Enomoto A. , Ping J. , Takahashi M.
Ann. N. Y. Acad. Sci.1086:169-184(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
9.

"DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212."
Kim J.Y. , Duan X. , Liu C.Y. , Jang M.H. , Guo J.U. , Pow-anpongkul N. , Kang E. , Song H. , Ming G.L.
Neuron63:761-773(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DISC1 AND AKT PROTEINS;TISSUE SPECIFICITY

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