GRIA4 ELISA Kit for Human(Homo sapiens) | EIAab.comGRIA4 ELISA Kit for Human(Homo sapiens) | EIAab.com

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GRIA4 (Gene name),

Glutamate receptor 4 (Protein name ), GRIA4_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

GRIA4(GLUR4);

Protein name:

Glutamate receptor 4(GluR-4;GluR4);

Alternative:

GluR-D;AMPA-selective glutamate receptor 4;Glutamate receptor ionotropic, AMPA 4(GluA4);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5.

Function:

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Interaction with CNIH2 and CNIH3 promotes cell surface expression.

Protein Attributes:

Sequence length:

902

Sequence:

50:

MRIISRQIVL | LFSGFWGLAM | GAFPSSVQIG | GLFIRNTDQE | YTAFRLAIFL |

100:

HNTSPNASEA | PFNLVPHVDN | IETANSFAVT | NAFCSQYSRG | VFAIFGLYDK |

150:

RSVHTLTSFC | SALHISLITP | SFPTEGESQF | VLQLRPSLRG | ALLSLLDHYE |

200:

WNCFVFLYDT | DRGYSILQAI | MEKAGQNGWH | VSAICVENFN | DVSYRQLLEE |

250:

LDRRQEKKFV | IDCEIERLQN | ILEQIVSVGK | HVKGYHYIIA | NLGFKDISLE |

300:

RFIHGGANVT | GFQLVDFNTP | MVIKLMDRWK | KLDQREYPGS | ETPPKYTSAL |

350:

TYDGVLVMAE | TFRSLRRQKI | DISRRGNAGD | CLANPAAPWG | QGIDMERTLK |

400:

QVRIQGLTGN | VQFDHYGRRV | NYTMDVFELK | STGPRKVGYW | NDMDKLVLIQ |

450:

DVPTLGNDTA | AIENRTVVVT | TIMESPYVMY | KKNHEMFEGN | DKYEGYCVDL |

500:

ASEIAKHIGI | KYKIAIVPDG | KYGARDADTK | IWNGMVGELV | YGKAEIAIAP |

550:

LTITLVREEV | IDFSKPFMSL | GISIMIKKPQ | KSKPGVFSFL | DPLAYEIWMC |

600:

IVFAYIGVSV | VLFLVSRFSP | YEWHTEEPED | GKEGPSDQPP | NEFGIFNSLW |

650:

FSLGAFMQQG | CDISPRSLSG | RIVGGVWWFF | TLIIISSYTA | NLAAFLTVER |

700:

MVSPIESAED | LAKQTEIAYG | TLDSGSTKEF | FRRSKIAVYE | KMWTYMRSAE |

750:

PSVFTRTTAE | GVARVRKSKG | KFAFLLESTM | NEYIEQRKPC | DTMKVGGNLD |

800:

SKGYGVATPK | GSSLRTPVNL | AVLKLSEAGV | LDKLKNKWWY | DKGECGPKDS |

850:

GSKDKTSALS | LSNVAGVFYI | LVGGLGLAML | VALIEFCYKS | RAEAKRMKLT |

900:

FSEAIRNKAR | LSITGSVGEN | GRVLTPDCPK | AVHTGTAIRQ | SSGLAVIASD |

902:

LP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

UniGene:

STRING:

9606.ENSP00000282499

String:

MIM:

KEGG:

SMR:

Uniprot:

FOR

ELISA Kit for Human GluR-4

ELISA Kit for Human GluR-4

ELISA Kit for Human GluR-4

CLIA Kit for Human GluR-4

CLIA Kit for Human GluR-4

CLIA Kit for Human GluR-4

Polyclonal Antibody for Human GluR-4

Polyclonal Antibody for Human GluR-4

Polyclonal Antibody for Human GluR-4

Monoclonal Antibody for Human GluR-4

Monoclonal Antibody for Human GluR-4

Monoclonal Antibody for Human GluR-4

Protein for Human GluR-4

Protein for Human GluR-4

Protein for Human GluR-4

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4."
Fletcher E.J. , Nutt S.L. , Hoo K.H. , Elliott C.E. , Korczak B. , McWhinnie E.A. , Kamboj R.K.
Recept. Channels3:21-31(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
4.

"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
Kato A.S. , Gill M.B. , Ho M.T. , Yu H. , Tu Y. , Siuda E.R. , Wang H. , Qian Y.W. , Nisenbaum E.S. , Tomita S. , Bredt D.S.
Neuron68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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