Grik1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGrik1 ELISA Kit for Rat(Rattus norvegicus)

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Grik1 (Gene name),

Glutamate receptor, ionotropic kainate 1 (Protein name ), GRIK1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Grik1(Glur5);

Protein name:

Glutamate receptor, ionotropic kainate 1(GluK1);

Alternative:

Glutamate receptor 5(GluR-5;GluR5);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17.

Function:

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

949

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

949:

SFNAIMEELG | ISLKNQKKLK | KKSRTKGKSS | FTSILTCHQR | RTQRKETVA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P22756

Pfam:

PF01094

UniGene:

Rn.10449

KEGG:

rno:29559

String:

P22756

STRING:

10116.ENSRNOP00000045594

Uniprot:

P22756

FOR

ELISA Kit for Rat GluK1

CLIA Kit for Rat GluK1

Polyclonal Antibody for Rat GluK1

Monoclonal Antibody for Rat GluK1

Protein for Rat GluK1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A glutamate receptor channel with high affinity for domoate and kainate."
Sommer B. , Burnashev N. , Verdoorn T.A. , Keinaenen K. , Sakmann B. , Seeburg P.H.
EMBO J.11:1651-1656(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
tissue: Brain.
2.

"Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development."
Bettler B. , Boulter J. , Hermans-Borgmeyer I. , O'Shea-Greenfield A. , Deneris E.S. , Moll C. , Borgmeyer U. , Hollmann M. , Heinemann S.F.
Neuron5:583-595(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
3.

"Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway."
Salinas G.D. , Blair L.A. , Needleman L.A. , Gonzales J.D. , Chen Y. , Li M. , Singer J.D. , Marshall J.
J. Biol. Chem.281:40164-40173(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLHL17
4.

"High-affinity kainate and domoate receptors in rat brain."
Lomeli H. , Wisden W. , Koehler M. , Keinaenen K. , Sommer B. , Seeburg P.H.
FEBS Lett.307:139-143(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
5.

"Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate."
Naur P. , Vestergaard B. , Skov L.K. , Egebjerg J. , Gajhede M. , Kastrup J.S.
FEBS Lett.579:1154-1160(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 445-820 IN COMPLEX WITH GLUTAMATE;SUBUNIT
6.

"Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity."
Mayer M.L.
Neuron45:539-552(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 446-821 IN COMPLEX WITH GLUTAMATE
7.

"Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists."
Mayer M.L. , Ghosal A. , Dolman N.P. , Jane D.E.
J. Neurosci.26:2852-2861(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 446-820 IN COMPLEXES WITH UBP302 AND UBP310;FUNCTION;SUBUNIT

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