Grm1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGrm1 ELISA Kit for Rat(Rattus norvegicus)

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Grm1 (Gene name),

Metabotropic glutamate receptor 1 (Protein name ), GRM1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Grm1(Gprc1a;Mglur1);

Protein name:

Metabotropic glutamate receptor 1(mGluR1);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3 (By similarity). Interacts with SIAH1 and GRASP.

Function:

Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1199

Sequence:

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1050:

1100:

1150:

1199:

TPPSPFRDSV | ASGSSVPSSP | VSESVLCTPP | NVTYASVILR | DYKQSSSTL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.87787

String:

P23385

KEGG:

rno:24414

SMR:

P23385

Pfam:

PF00003

Uniprot:

P23385

FOR

ELISA Kit for Rat mGluR1

CLIA Kit for Rat mGluR1

Polyclonal Antibody for Rat mGluR1

Monoclonal Antibody for Rat mGluR1

Protein for Rat mGluR1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Sequence and expression of a metabotropic glutamate receptor."
Masu M. , Tanabe Y. , Tsuchida K. , Shigemoto R. , Nakanishi S.
Nature349:760-765(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
strain: Sprague-Dawley.
tissue: Brain.
2.

"Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain."
Houamed K.M. , Kuijper J.L. , Gilbert T.L. , Haldeman B.A. , O'Hara P.J. , Mulvihill E.R. , Almers W. , Hagen F.S.
Science252:1318-1321(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
tissue: Brain.
3.

"A family of metabotropic glutamate receptors."
Tanabe Y. , Masu M. , Ishii T. , Shigemoto R. , Nakanishi S.
Neuron8:169-179(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 1B)
tissue: Brain.
4.

"Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes."
Pin J.-P. , Waeber C. , Prezeau L. , Bockaert J. , Heinemann S.F.
Proc. Natl. Acad. Sci. U.S.A.89:10331-10335(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 1C);FUNCTION
tissue: Brain.
5.

"Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors."
Ishikawa K. , Nash S.R. , Nishimune A. , Neki A. , Kaneko S. , Nakanishi S.
Genes Cells4:381-390(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIAH1
6.

"Cys-140 is critical for metabotropic glutamate receptor-1 dimerization."
Ray K. , Hauschild B.C.
J. Biol. Chem.275:34245-34251(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERCHAIN DISULFIDE BOND;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-67; CYS-109 AND CYS-140
7.

"Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
Kitano J. , Kimura K. , Yamazaki Y. , Soda T. , Shigemoto R. , Nakajima Y. , Nakanishi S.
J. Neurosci.22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRASP
8.

"Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor."
Kunishima N. , Shimada Y. , Tsuji Y. , Sato T. , Yamamoto M. , Kumasaka T. , Nakanishi S. , Jingami H. , Morikawa K.
Nature407:971-977(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 33-522 ALONE AND IN COMPLEX WITH GLUTAMATE;SUBUNIT;GLYCOSYLATION AT ASN-98 AND ASN-223;GLUTAMATE-BINDING SITES;DISULFIDE BONDS
9.

"Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+."
Tsuchiya D. , Kunishima N. , Kamiya N. , Jingami H. , Morikawa K.
Proc. Natl. Acad. Sci. U.S.A.99:2660-2665(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 33-522 IN COMPLEX WITH GLUTAMATE AND ANTAGONIST;SUBUNIT;DISULFIDE BONDS

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