GSK3A ELISA Kit for Human(Homo sapiens) | EIAab.comGSK3A ELISA Kit for Human(Homo sapiens)

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GSK3A (Gene name),

Glycogen synthase kinase-3 alpha (Protein name ), GSK3A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GSK3A;

Protein name:

Glycogen synthase kinase-3 alpha(GSK-3 alpha);

Alternative:

2.7.11.1;Serine/threonine-protein kinase GSK3A);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-catenin.

Function:

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

483

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

483:

TTTLTPSSQA | LTETPTSSDW | QSTDATPTLT | NSS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

606784

UniGene:

Hs.466828

String:

P49840

SMR:

P49840

Pfam:

PF00069

STRING:

9606.ENSP00000222330

KEGG:

hsa:2931

Uniprot:

P49840

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ELISA Kit for Human GSK-3 alpha

Cat.:

E0767m

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96T

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ELISA Kit for Human GSK-3 alpha

Cat.:

E0767r

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96T

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ELISA Kit for Human GSK-3 alpha

Cat.:

E0767h

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96T

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CLIA Kit for Human GSK-3 alpha

Cat.:

U0767h

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MSDS:

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Packing:

96T

CLIA Kit for Human GSK-3 alpha

Cat.:

U0767m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human GSK-3 alpha

Cat.:

U0767r

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Packing:

96T

Polyclonal Antibody for Human GSK-3 alpha

Cat.:

P0767Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GSK-3 alpha

Cat.:

P0767Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GSK-3 alpha

Cat.:

P0767Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human GSK-3 alpha

Protein for Human GSK-3 alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Glycogen synthase kinase 3 and dorsoventral patterning in Xenopus embryos."
He X. , Saint-Jeannet J.P. , Woodgett J.R. , Varmus H.E. , Dawid I.B.
Submitted (1995-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Foreskin.
2.

"Isolation of cDNA clones for human glycogen synthase kinase 3alpha."
Hoshino T. , Kondo K. , Ishiguro K. , Takashima A. , Imahori K.
Submitted (1997-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Eye.
tissue: Pancreas.
5.

"Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes."
Nikoulina S.E. , Ciaraldi T.P. , Mudaliar S. , Mohideen P. , Carter L. , Henry R.R.
Diabetes49:263-271(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH DIABETES MELLITUS
6.

"GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides."
Phiel C.J. , Wilson C.A. , Lee V.M. , Klein P.S.
Nature423:435-439(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH ALZHEIMER DISEASE;FUNCTION
7.

"GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt."
Asuni A.A. , Hooper C. , Reynolds C.H. , Lovestone S. , Anderton B.H. , Killick R.
Eur. J. Neurosci.24:3387-3392(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN WNT SIGNALING;INTERACTION WITH AXIN1 AND CTNNB1/BETA-CATENIN
8.

"Glycogen synthase kinase-3: properties, functions, and regulation."
Ali A. , Hoeflich K.P. , Woodgett J.R.
Chem. Rev.101:2527-2540(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;ENZYME REGULATION
9.

"The role of GSK3 in glucose homeostasis and the development of insulin resistance."
Lee J. , Kim M.S.
Diabetes Res. Clin. Pract.77:S49-S57(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
10.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND SER-72;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Glycogen synthase kinase 3: more than a namesake."
Rayasam G.V. , Tulasi V.K. , Sodhi R. , Davis J.A. , Ray A.
Br. J. Pharmacol.156:885-898(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;ENZYME REGULATION
14.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-77 AND SER-97;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-461

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