HAND1 ELISA Kit for Human(Homo sapiens) | EIAab.comHAND1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HAND1(Gene name) > Human

HAND1 (Gene name),

Heart- and neural crest derivatives-expressed protein 1 (Protein name ), HAND1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HAND1(BHLHA27;EHAND);

Protein name:

Heart- and neural crest derivatives-expressed protein 1;

Alternative:

Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(eHAND);Class A basic helix-loop-helix protein 27(bHLHa27);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC.

Function:

Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box).

Subcellular Location:

Nucleus nucleoplasm Nucleus nucleolus Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity.

Protein Attributes:

Sequence length:

215

Sequence:

50:

100:

150:

200:

215:

RTGWPQQVWA | LELNQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000231121

KEGG:

hsa:9421

MIM:

602406

UniGene:

Hs.152531

String:

O96004

Pfam:

PF00010

SMR:

O96004

Uniprot:

O96004

FOR

ELISA Kit for Human Heart- and neural crest derivatives-expressed protein 1

CLIA Kit for Human Heart- and neural crest derivatives-expressed protein 1

Polyclonal Antibody for Human Heart- and neural crest derivatives-expressed protein 1

Monoclonal Antibody for Human Heart- and neural crest derivatives-expressed protein 1

Protein for Human Heart- and neural crest derivatives-expressed protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart."
Knoefler M. , Meinhardt G. , Vasicek R. , Husslein P. , Egarter C.
Gene224:77-86(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Heart.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.

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