Hand1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comHand1 ELISA Kit for Rat(Rattus norvegicus)

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Hand1 (Gene name),

Heart- and neural crest derivatives-expressed protein 1 (Protein name ), HAND1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Hand1(Ehand);

Protein name:

Heart- and neural crest derivatives-expressed protein 1;

Alternative:

Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(eHAND);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC.

Function:

Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box).

Subcellular Location:

Nucleus nucleoplasm Nucleus nucleolus Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity.

Protein Attributes:

Sequence length:

216

Sequence:

50:

100:

150:

200:

216:

GRTGWPQQVW | ALELNQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000003486

KEGG:

rno:59112

String:

P97832

UniGene:

Rn.100787

UniGene:

Rn.224598

Pfam:

PF00010

Uniprot:

P97832

FOR

ELISA Kit for Rat Heart- and neural crest derivatives-expressed protein 1

CLIA Kit for Rat Heart- and neural crest derivatives-expressed protein 1

Polyclonal Antibody for Rat Heart- and neural crest derivatives-expressed protein 1

Monoclonal Antibody for Rat Heart- and neural crest derivatives-expressed protein 1

Protein for Rat Heart- and neural crest derivatives-expressed protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of helix-loop-helix proteins in vascular smooth muscle."
Kemp P. , Grainger D. , Metcalfe J.
Submitted (1999-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Wistar.
tissue: Aorta.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.

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