Gene name:
Hand2 (Dhand;Hed;Thing2) ;
Protein name:
Heart- and neural crest derivatives-expressed protein 2 ;
Alternative:
Helix-loop-helix transcription factor expressed in embryo and deciduum ;Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND) ;Thing-2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related transcription factors).
Function:
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSLVGGFPHH | PVVHHEGYPF | AAAAAAAAAA | AASRCSHEEN | PYFHGWLIGH |
100:
PEMSPPDYSM | ALSYSPEYAS | GAAGLDHSHY | GGVPPGAGPP | GLGGPRPVKR |
150:
RGTANRKERR | RTQSINSAFA | ELRECIPNVP | ADTKLSKIKT | LRLATSYIAY |
200:
LMDLLAKDDQ | NGEAEAFKAE | IKKTDVKEEK | RKKELNEILK | STVSSNDKKT |
217:
KGRTGWPQHV | WALELKQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
Rat
ELISA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
ELISA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
ELISA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
ELISA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
CLIA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
CLIA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
CLIA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
CLIA Kit for Mouse Heart- and neural crest derivatives-expressed protein 2
Polyclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Polyclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Polyclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Polyclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Monoclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Monoclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Monoclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Monoclonal Antibody for Mouse Heart- and neural crest derivatives-expressed protein 2
Protein for Mouse Heart- and neural crest derivatives-expressed protein 2
Protein for Mouse Heart- and neural crest derivatives-expressed protein 2
Protein for Mouse Heart- and neural crest derivatives-expressed protein 2
Protein for Mouse Heart- and neural crest derivatives-expressed protein 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Embryo .
2.
"The transcriptional landscape of the mammalian genome."
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 92-203
strain :
129/Sv .
tissue :
Embryoid bodies .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DEVELOPMENTAL STAGE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DEVELOPMENTAL STAGE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DEVELOPMENTAL STAGE