Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > HCAR3(Gene name) > Human
  • Add your favorite
  • HCAR3 (Gene name),
  • Hydroxycarboxylic acid receptor 3 (Protein name ),  HCAR3_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    HCAR3(GPR109B;HCA3;HM74B;NIACR2);
    Protein name:
    Hydroxycarboxylic acid receptor 3;
    Alternative:
    G-protein coupled receptor HM74;G-protein coupled receptor 109B;Niacin receptor 2;G-protein coupled receptor HM74B;Nicotinic acid receptor 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    387
    Sequence:
    50:
    MNRHHLQDHF | LEIDKKNCCV | FRDDFIAKVL | PPVLGLEFIF | GLLGNGLALW | 
    100:
    IFCFHLKSWK | SSRIFLFNLA | VADFLLIICL | PFVMDYYVRR | SDWKFGDIPC | 
    150:
    RLVLFMFAMN | RQGSIIFLTV | VAVDRYFRVV | HPHHALNKIS | NWTAAIISCL | 
    200:
    LWGITVGLTV | HLLKKKLLIQ | NGPANVCISF | SICHTFRWHE | AMFLLEFLLP | 
    250:
    LGIILFCSAR | IIWSLRQRQM | DRHAKIKRAI | TFIMVVAIVF | VICFLPSVVV | 
    300:
    RIRIFWLLHT | SGTQNCEVYR | SVDLAFFITL | SFTYMNSMLD | PVVYYFSSPS | 
    350:
    FPNFFSTLIN | RCLQRKMTGE | PDNNRSTSVE | LTGDPNKTRG | APEALMANSG | 
    387:
    EPWSPSYLGP | TSNNHSKKGH | CHQEPASLEK | QLGCCIE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hydroxycarboxylic acid receptor 3
    CLIA Kit for Human Hydroxycarboxylic acid receptor 3
    Polyclonal Antibody for Human Hydroxycarboxylic acid receptor 3
    Monoclonal Antibody for Human Hydroxycarboxylic acid receptor 3
    Protein for Human Hydroxycarboxylic acid receptor 3

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
      Nomura H. , Nielsen B.W. , Matsushima K.
      Int. Immunol.5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS PRO-173; LEU-198; ARG-253; MET-317 AND MET-346
      tissue: Monocyte.
    2. 2.
      "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M. , Sato T. , Okouchi I. , Arita M. , Futami K. , Matsumoto S. , Tsutsumi S. , Aburatani H. , Asai K. , Akiyama Y.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-173; LEU-198; ARG-253; MET-317 AND MET-346
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PRO-173; LEU-198; ARG-253; MET-317 AND MET-346
      tissue: Neutrophil.
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2007-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PRO-173; LEU-198; ARG-253; MET-317 AND MET-346
      tissue: Pancreas.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;CHARACTERIZATION
    8. 8.
      "Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis."
      Ahmed K. , Tunaru S. , Langhans C.-D. , Hanson J. , Michalski C.W. , Koelker S. , Jones P.M. , Okun J.G. , Offermanns S.
      J. Biol. Chem.284:21928-21933(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ARG-111
    9. 9.
      "International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)."
      Offermanns S. , Colletti S.L. , Lovenberg T.W. , Semple G. , Wise A. , Ijzerman A.P.
      Pharmacol. Rev.63:269-290(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5
    Top Searches
    Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    鄂ICP备10015095号-1

    鄂公网安备 42018502005535号

    Twitter