Gene name:
HCAR3(GPR109B;HCA3;HM74B;NIACR2);
Protein name:
Hydroxycarboxylic acid receptor 3;
Alternative:
G-protein coupled receptor HM74;G-protein coupled receptor 109B;Niacin receptor 2;G-protein coupled receptor HM74B;Nicotinic acid receptor 2;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MNRHHLQDHF | LEIDKKNCCV | FRDDFIAKVL | PPVLGLEFIF | GLLGNGLALW |
100:
IFCFHLKSWK | SSRIFLFNLA | VADFLLIICL | PFVMDYYVRR | SDWKFGDIPC |
150:
RLVLFMFAMN | RQGSIIFLTV | VAVDRYFRVV | HPHHALNKIS | NWTAAIISCL |
200:
LWGITVGLTV | HLLKKKLLIQ | NGPANVCISF | SICHTFRWHE | AMFLLEFLLP |
250:
LGIILFCSAR | IIWSLRQRQM | DRHAKIKRAI | TFIMVVAIVF | VICFLPSVVV |
300:
RIRIFWLLHT | SGTQNCEVYR | SVDLAFFITL | SFTYMNSMLD | PVVYYFSSPS |
350:
FPNFFSTLIN | RCLQRKMTGE | PDNNRSTSVE | LTGDPNKTRG | APEALMANSG |
387:
EPWSPSYLGP | TSNNHSKKGH | CHQEPASLEK | QLGCCIE

Vaild Sequence:
Related Databases
Uniprot: