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Index > Protein center > HECW2(Gene name) > Human
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  • HECW2 (Gene name),
  • E3 ubiquitin-protein ligase HECW2 (Protein name ),  HECW2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HECW2(KIAA1301;NEDL2);
    Protein name:
    E3 ubiquitin-protein ligase HECW2;
    Alternative:
    NEDD4-like E3 ubiquitin-protein ligase 2;HECT, C2 and WW domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TP73.
    Function:
    E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1572
    Sequence:
    50:
    MASSAREHLL | FVRRRNPQMR | YTLSPENLQS | LAAQSSMPEN | MTLQRANSDT | 
    100:
    DLVTSESRSS | LTASMYEYTL | GQAQNLIIFW | DIKEEVDPSD | WIGLYHIDEN | 
    150:
    SPANFWDSKN | RGVTGTQKGQ | IVWRIEPGPY | FMEPEIKICF | KYYHGISGAL | 
    200:
    RATTPCITVK | NPAVMMGAEG | MEGGASGNLH | SRKLVSFTLS | DLRAVGLKKG | 
    250:
    MFFNPDPYLK | MSIQPGKKSS | FPTCAHHGQE | RRSTIISNTT | NPIWHREKYS | 
    300:
    FFALLTDVLE | IEIKDKFAKS | RPIIKRFLGK | LTIPVQRLLE | RQAIGDQMLS | 
    350:
    YNLGRRLPAD | HVSGYLQFKV | EVTSSVHEDA | SPEAVGTILG | VNSVNGDLGS | 
    400:
    PSDDEDMPGS | HHDSQVCSNG | PVSEDSAADG | TPKHSFRTSS | TLEIDTEELT | 
    450:
    STSSRTSPPR | GRQDSLNDYL | DAIEHNGHSR | PGTATCSERS | MGASPKLRSS | 
    500:
    FPTDTRLNAM | LHIDSDEEDH | EFQQDLGYPS | SLEEEGGLIM | FSRASRADDG | 
    550:
    SLTSQTKLED | NPVENEEAST | HEAASFEDKP | ENLPELAESS | LPAGPAPEEG | 
    600:
    EGGPEPQPSA | DQGSAELCGS | QEVDQPTSGA | DTGTSDASGG | SRRAVSETES | 
    650:
    LDQGSEPSQV | SSETEPSDPA | RTESVSEAST | RPEGESDLEC | ADSSCNESVT | 
    700:
    TQLSSVDTRC | SSLESARFPE | TPAFSSQEEE | DGACAAEPTS | SGPAEGSQES | 
    750:
    VCTAGSLPVV | QVPSGEDEGP | GAESATVPDQ | EELGEVWQRR | GSLEGAAAAA | 
    800:
    ESPPQEEGSA | GEAQGTCEGA | TAQEEGATGG | SQANGHQPLR | SLPSVRQDVS | 
    850:
    RYQRVDEALP | PNWEARIDSH | GRIFYVDHVN | RTTTWQRPTA | PPAPQVLQRS | 
    900:
    NSIQQMEQLN | RRYQSIRRTM | TNERPEENTN | AIDGAGEEAD | FHQASADFRR | 
    950:
    ENILPHSTSR | SRITLLLQSP | PVKFLISPEF | FTVLHSNPSA | YRMFTNNTCL | 
    1000:
    KHMITKVRRD | THHFERYQHN | RDLVGFLNMF | ANKQLELPRG | WEMKHDHQGK | 
    1050:
    AFFVDHNSRT | TTFIDPRLPL | QSSRPTSALV | HRQHLTRQRS | HSAGEVGEDS | 
    1100:
    RHAGPPVLPR | PSSTFNTVSR | PQYQDMVPVA | YNDKIVAFLR | QPNIFEILQE | 
    1150:
    RQPDLTRNHS | LREKIQFIRT | EGTPGLVRLS | SDADLVMLLS | LFEEEIMSYV | 
    1200:
    PPHALLHPSY | CQSPRGSPVS | SPQNSPGTQR | ANARAPAPYK | RDFEAKLRNF | 
    1250:
    YRKLETKGYG | QGPGKLKLII | RRDHLLEDAF | NQIMGYSRKD | LQRNKLYVTF | 
    1300:
    VGEEGLDYSG | PSREFFFLVS | RELFNPYYGL | FEYSANDTYT | VQISPMSAFV | 
    1350:
    DNHHEWFRFS | GRILGLALIH | QYLLDAFFTR | PFYKALLRIL | CDLSDLEYLD | 
    1400:
    EEFHQSLQWM | KDNDIHDILD | LTFTVNEEVF | GQITERELKP | GGANIPVTEK | 
    1450:
    NKKEYIERMV | KWRIERGVVQ | QTESLVRGFY | EVVDARLVSV | FDARELELVI | 
    1500:
    AGTAEIDLSD | WRNNTEYRGG | YHDNHIVIRW | FWAAVERFNN | EQRLRLLQFV | 
    1550:
    TGTSSIPYEG | FASLRGSNGP | RRFCVEKWGK | ITALPRAHTC | FNRLDLPPYP | 
    1572:
    SFSMLYEKLL | TAVEETSTFG | LE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase HECW2
    ELISA Kit for Human E3 ubiquitin-protein ligase HECW2
    CLIA Kit for Human E3 ubiquitin-protein ligase HECW2
    CLIA Kit for Human E3 ubiquitin-protein ligase HECW2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase HECW2
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase HECW2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase HECW2
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase HECW2
    Protein for Human E3 ubiquitin-protein ligase HECW2
    Protein for Human E3 ubiquitin-protein ligase HECW2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1352-1572 (ISOFORM 1)
      tissue: Uterus.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Heart.
      tissue: Lung.
    5. 5.
      "A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity."
      Miyazaki K. , Ozaki T. , Kato C. , Hanamoto T. , Fujita T. , Irino S. , Watanabe K. , Nakagawa T. , Nakagawara A.
      Biochem. Biophys. Res. Commun.308:106-113(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP73;TISSUE SPECIFICITY
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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