HERC2 ELISA Kit for Human(Homo sapiens) | EIAab.comHERC2 ELISA Kit for Human(Homo sapiens)

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HERC2 (Gene name),

E3 ubiquitin-protein ligase HERC2 (Protein name ), HERC2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HERC2;

Protein name:

E3 ubiquitin-protein ligase HERC2;

Alternative:

HECT domain and RCC1-like domain-containing protein 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (when phosphorylated at Thr-4827) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA.

Function:

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintainance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.

Subcellular Location:

Cytoplasm Nucleus Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8.

Protein Attributes:

Sequence length:

4834

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LTGEPAADDS | SDDSDNEDVD | SFASDSTQDY | LTGH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O95714

SMR:

O95714

MIM:

227220

UniGene:

Hs.434890

KEGG:

hsa:8924

Pfam:

PF03256

Uniprot:

O95714

FOR

ELISA Kit for Human E3 ubiquitin-protein ligase HERC2

CLIA Kit for Human E3 ubiquitin-protein ligase HERC2

Polyclonal Antibody for Human E3 ubiquitin-protein ligase HERC2

Monoclonal Antibody for Human E3 ubiquitin-protein ligase HERC2

Protein for Human E3 ubiquitin-protein ligase HERC2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities."
Ji Y. , Walkowicz M.J. , Buiting K. , Johnson D.K. , Tarvin R.E. , Rinchik E.M. , Horsthemke B. , Stubbs L. , Nicholls R.D.
Hum. Mol. Genet.8:533-542(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human."
Ji Y. , Rebert N.A. , Joslin J.M. , Higgins M.J. , Schultz R.A. , Nicholls R.D.
Genome Res.10:319-329(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2818-2895; 2909-2957; 2963-3290; 3317-3363; 3389-3430; 3458-3495; 3512-3527; 3533-3633; 3635-3821; 3826-4084; 4097-4505 AND 4529-4834;GENE STRUCTURE
4.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2454 AND SER-2928;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
5.

"Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene."
Kayser M. , Liu F. , Janssens A.C.J.W. , Rivadeneira F. , Lao O. , van Duijn K. , Vermeulen M. , Arp P. , Jhamai M.M. , van Ijcken W.F.J. , den Dunnen J.T. , Heath S. , Zelenika D. , Despriet D.D.G. , Klaver C.C.W. , Vingerling J.R. , de Jong P.T.V.M. , Hofman A. , more...
Am. J. Hum. Genet.82:411-423(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SHEP1
6.

"A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color."
Sturm R.A. , Duffy D.L. , Zhao Z.Z. , Leite F.P.M. , Stark M.S. , Hayward N.K. , Martin N.G. , Montgomery G.W.
Am. J. Hum. Genet.82:424-431(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SHEP1
7.

"Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression."
Eiberg H. , Troelsen J. , Nielsen M. , Mikkelsen A. , Mengel-From J. , Kjaer K.W. , Hansen L.
Hum. Genet.123:177-187(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SHEP1;REGULATION OF OCA2
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2928; SER-4810; SER-4811 AND SER-4814;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2454;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
11.

"Human eye colour and HERC2, OCA2 and MATP."
Mengel-From J. , Borsting C. , Sanchez J.J. , Eiberg H. , Morling N.
Forensic Sci. Int. Genet.4:323-328(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MISCELLANEOUS
12.

"HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes."
Bekker-Jensen S. , Rendtlew Danielsen J. , Fugger K. , Gromova I. , Nerstedt A. , Lukas C. , Bartek J. , Lukas J. , Mailand N.
Nat. Cell Biol.12:80-86(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RNF8;PHOSPHORYLATION AT THR-4827;MUTAGENESIS OF THR-4827;SUBCELLULAR LOCATION
13.

"Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase."
Kang T.H. , Lindsey-Boltz L.A. , Reardon J.T. , Sancar A.
Proc. Natl. Acad. Sci. U.S.A.107:4890-4895(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITIN LIGASE ACTIVITY;INTERACTION WITH XPA;SUBCELLULAR LOCATION
14.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2454 AND SER-2928;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-647; THR-1944 AND SER-2928;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger."
Danielsen J.R. , Povlsen L.K. , Villumsen B.H. , Streicher W. , Nilsson J. , Wikstrom M. , Bekker-Jensen S. , Mailand N.
J. Cell Biol.197:179-187(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;FUNCTION;SUMO-BINDING;DOMAIN;INTERACTION WITH RNF8;MUTAGENESIS OF CYS-2708 AND CYS-2711
18.

"Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture."
Al-Hakim A.K. , Bashkurov M. , Gingras A.C. , Durocher D. , Pelletier L.
Mol. Cell. Proteomics11:M111.014233.01-M111.014233.14(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCP110; CEP97 AND NEURL4;SUBCELLULAR LOCATION
19.

"Structure of the first RCC1-like domain of HERC2."
Tempel W. , Khan M.B. , Dong A. , Hu J. , Li Y. , Bountra C. , Arrowsmith C.H. , Edwards A.M. , Tong Y.
Submitted (2013-06) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 417-790;RCC1 REPEATS
20.

"A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder."
Puffenberger E.G. , Jinks R.N. , Wang H. , Xin B. , Fiorentini C. , Sherman E.A. , Degrazio D. , Shaw C. , Sougnez C. , Cibulskis K. , Gabriel S. , Kelley R.I. , Morton D.H. , Strauss K.A.
Hum. Mutat.33:1639-1646(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MRT38 LEU-594;CHARACTERIZATION OF VARIANT MRT38 LEU-594

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