Gene name:
HERC4 (KIAA1593) ;
Protein name:
Probable E3 ubiquitin-protein ligase HERC4 ;
Alternative:
HECT domain and RCC1-like domain-containing protein 4 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
Subcellular Location:
Cytoplasm
cytosol
shows a punctate cytoplasmic distribution.
Protein Attributes:
50:
MLCWGNASFG | QLGLGGIDEE | IVLEPRKSDF | FINKRVRDVG | CGLRHTVFVL |
100:
DDGTVYTCGC | NDLGQLGHEK | SRKKPEQVVA | LDAQNIVAVS | CGEAHTLALN |
150:
DKGQVYAWGL | DSDGQLGLVG | SEECIRVPRN | IKSLSDIQIV | QVACGYYHSL |
200:
ALSKASEVFC | WGQNKYGQLG | LGTDCKKQTS | PQLLKSLLGI | PFMQVAAGGA |
250:
HSFVLTLSGA | IFGWGRNKFG | QLGLNDENDR | YVPNLLKSLR | SQKIVYICCG |
300:
EDHTAALTKE | GGVFTFGAGG | YGQLGHNSTS | HEINPRKVFE | LMGSIVTEIA |
350:
CGRQHTSAFV | PSSGRIYSFG | LGGNGQLGTG | STSNRKSPFT | VKGNWYPYNG |
400:
QCLPDIDSEE | YFCVKRIFSG | GDQSFSHYSS | PQNCGPPDDF | RCPNPTKQIW |
450:
TVNEALIQKW | LSYPSGRFPV | EIANEIDGTF | SSSGCLNGSF | LAVSNDDHYR |
500:
TGTRFSGVDM | NAARLLFHKL | IQPDHPQISQ | QVAASLEKNL | IPKLTSSLPD |
550:
VEALRFYLTL | PECPLMSDSN | NFTTIAIPFG | TALVNLEKAP | LKVLENWWSV |
600:
LEPPLFLKIV | ELFKEVVVHL | LKLYKIGIPP | SERRIFNSFL | HTALKVLEIL |
650:
HRVNEKMGQI | IQYDKFYIHE | VQELIDIRND | YINWVQQQAY | GMDVNHGLTE |
700:
LADIPVTICT | YPFVFDAQAK | TTLLQTDAVL | QMQMAIDQAH | RQNVSSLFLP |
750:
VIESVNPCLI | LVVRRENIVG | DAMEVLRKTK | NIDYKKPLKV | IFVGEDAVDA |
800:
GGVRKEFFLL | IMRELLDPKY | GMFRYYEDSR | LIWFSDKTFE | DSDLFHLIGV |
850:
ICGLAIYNCT | IVDLHFPLAL | YKKLLKKKPS | LDDLKELMPD | VGRSMQQLLD |
900:
YPEDDIEETF | CLNFTITVEN | FGATEVKELV | LNGADTAVNK | QNRQEFVDAY |
950:
VDYIFNKSVA | SLFDAFHAGF | HKVCGGKVLL | LFQPNELQAM | VIGNTNYDWK |
1000:
ELEKNTEYKG | EYWAEHPTIK | IFWEVFHELP | LEKKKQFLLF | LTGSDRIPIL |
1050:
GMKSLKLVIQ | STGGGEEYLP | VSHTCFNLLD | LPKYTEKETL | RSKLIQAIDH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Probable E3 ubiquitin-protein ligase HERC4
ELISA Kit for Human Probable E3 ubiquitin-protein ligase HERC4
ELISA Kit for Human Probable E3 ubiquitin-protein ligase HERC4
CLIA Kit for Human Probable E3 ubiquitin-protein ligase HERC4
CLIA Kit for Human Probable E3 ubiquitin-protein ligase HERC4
CLIA Kit for Human Probable E3 ubiquitin-protein ligase HERC4
Polyclonal Antibody for Human Probable E3 ubiquitin-protein ligase HERC4
Polyclonal Antibody for Human Probable E3 ubiquitin-protein ligase HERC4
Polyclonal Antibody for Human Probable E3 ubiquitin-protein ligase HERC4
Monoclonal Antibody for Human Probable E3 ubiquitin-protein ligase HERC4
Monoclonal Antibody for Human Probable E3 ubiquitin-protein ligase HERC4
Monoclonal Antibody for Human Probable E3 ubiquitin-protein ligase HERC4
Protein for Human Probable E3 ubiquitin-protein ligase HERC4
Protein for Human Probable E3 ubiquitin-protein ligase HERC4
Protein for Human Probable E3 ubiquitin-protein ligase HERC4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
tissue :
Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Blood .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]