HESX1 ELISA Kit for Human(Homo sapiens) | EIAab.comHESX1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HESX1(Gene name) > Human

HESX1 (Gene name),

Homeobox expressed in ES cells 1 (Protein name ), HESX1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HESX1(HANF);

Protein name:

Homeobox expressed in ES cells 1;

Alternative:

Homeobox protein ANF(hAnf);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Can form heterodimers with PROP1 in binding to DNA (By similarity). Interacts with TLE1.

Function:

Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

185

Sequence:

50:

100:

150:

185:

RIQIWFQNRR | AKLKRSHRES | QFLMAKKNFN | TNLLE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9UBX0

String:

Q9UBX0

Pfam:

PF00046

KEGG:

hsa:8820

UniGene:

Hs.171980

MIM:

182230

STRING:

9606.ENSP00000295934

Uniprot:

Q9UBX0

FOR

ELISA Kit for Human Homeobox expressed in ES cells 1

CLIA Kit for Human Homeobox expressed in ES cells 1

Polyclonal Antibody for Human Homeobox expressed in ES cells 1

Monoclonal Antibody for Human Homeobox expressed in ES cells 1

Protein for Human Homeobox expressed in ES cells 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse."
Dattani M.T. , Martinez-Barbera J.-P. , Thomas P.Q. , Brickman J.M. , Gupta R. , Maartensson I.-L. , Toresson H. , Fox M. , Wales J.K.H. , Hindmarsh P.C. , Krauss S. , Beddington R.S.P. , Robinson I.C.A.F.
Nat. Genet.19:125-133(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SOD CYS-160;VARIANT SER-125
tissue: Fibrosarcoma.
2.

"Anf: a novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis."
Kazanskaya O.V. , Severtzova E.A. , Barth K.A. , Ermakova G.V. , Lukyanov S.A. , Benyumov A.O. , Pannese M. , Boncinelli E. , Wilson S.W. , Zaraisky A.G.
Gene200:25-34(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Teratocarcinoma.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis."
Dasen J.S. , Martinez-Barbera J.-P. , Herman T.S. , O'Connell S. , Olson L. , Ju B. , Tollkuhn J. , Baek S.H. , Rose D.W. , Rosenfeld M.G.
Genes Dev.15:3193-3207(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TLE1
5.

"Role of conserved salt bridges in homeodomain stability and DNA binding."
Torrado M. , Revuelta J. , Gonzalez C. , Corzana F. , Bastida A. , Asensio J.L.
J. Biol. Chem.284:23765-23779(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 108-174;DNA-BINDING
6.

"Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia."
Thomas P.Q. , Dattani M.T. , Brickman J.M. , McNay D. , Warne G. , Zacharin M. , Cameron F. , Hurst J. , Woods K. , Dunger D. , Stanhope R. , Forrest S. , Robinson I.C. , Beddington R.S.
Hum. Mol. Genet.10:39-45(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SOD LEU-170;VARIANT GHDPA ALA-181;VARIANT CPHD5 HIS-6
7.

"A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction."
Carvalho L.R. , Woods K.S. , Mendonca B.B. , Marcal N. , Zamparini A.L. , Stifani S. , Brickman J.M. , Arnhold I.J. , Dattani M.T.
J. Clin. Invest.112:1192-1201(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CPHD5 THR-26;CHARACTERIZATION OF VARIANT CPHD5 THR-26
8.

"HESX1 mutations are an uncommon cause of septooptic dysplasia and hypopituitarism."
McNay D.E.G. , Turton J.P. , Kelberman D. , Woods K.S. , Brauner R. , Papadimitriou A. , Keller E. , Keller A. , Haufs N. , Krude H. , Shalet S.M. , Dattani M.T.
J. Clin. Endocrinol. Metab.92:691-697(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GHDPA LYS-149;CHARACTERIZATION OF VARIANT GHDPA LYS-149

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