Hey1 ELISA Kit for Mouse(Mus musculus) | EIAab.comHey1 ELISA Kit for Mouse(Mus musculus)

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Hey1 (Gene name),

Hairy/enhancer-of-split related with YRPW motif protein 1 (Protein name ), HEY1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Hey1(Herp2;Hesr1;Hrt1);

Protein name:

Hairy/enhancer-of-split related with YRPW motif protein 1;

Alternative:

Hairy-related transcription factor 1(HRT-1;mHRT1);Hairy and enhancer of split-related protein 1(HESR-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

May self-associate (By similarity). Interacts with HES1, NCOR1 and SIN3A (By similarity). Interacts with GATA4, GATA6 and HDAC1 and HEYL. Interacts with CCDC89/BOIP.

Function:

Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

299

Sequence:

50:

100:

150:

200:

250:

299:

SPPLLSSVAS | LSAFPFSFSS | FHLLSPSTPT | QAANLGKPYR | PWGTEIGAF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9WV93

UniGene:

Mm.29581

String:

Q9WV93

Pfam:

PF07527

Uniprot:

Q9WV93

FOR

ELISA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif protein 1

CLIA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif protein 1

Polyclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif protein 1

Monoclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif protein 1

Protein for Mouse Hairy/enhancer-of-split related with YRPW motif protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split."
Kokubo H. , Lun Y. , Johnson R.L.
Biochem. Biophys. Res. Commun.260:459-465(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6J.
2.

"Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
Leimeister C. , Externbrinck A. , Klamt B. , Gessler M.
Mech. Dev.85:173-177(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
3.

"Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes."
Maier M.M. , Gessler M.
Biochem. Biophys. Res. Commun.275:652-660(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
4.

"Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
Steidl C. , Leimeister C. , Klamt B. , Maier M. , Nanda I. , Dixon M. , Clarke R. , Schmid M. , Gessler M.
Genomics66:195-203(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
Nakagawa O. , McFadden D.G. , Nakagawa M. , Yanagisawa H. , Hu T. , Srivastava D. , Olson E.N.
Proc. Natl. Acad. Sci. U.S.A.97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
6.

"The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina."
Satow T. , Bae S.-K. , Inoue T. , Inoue C. , Miyoshi G. , Tomita K. , Bessho Y. , Hashimoto N. , Kageyama R.
J. Neurosci.21:1265-1273(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
7.

"HERP, a new primary target of Notch regulated by ligand binding."
Iso T. , Sartorelli V. , Chung G. , Shichinohe T. , Kedes L. , Hamamori Y.
Mol. Cell. Biol.21:6071-6079(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION
8.

"HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling."
Iso T. , Sartorelli V. , Poizat C. , Iezzi S. , Wu H.-Y. , Chung G. , Kedes L. , Hamamori Y.
Mol. Cell. Biol.21:6080-6089(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HDAC1
9.

"HERP1 is a cell type-specific primary target of Notch."
Iso T. , Chung G. , Hamamori Y. , Kedes L.
J. Biol. Chem.277:6598-6607(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION
10.

"Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse."
Van Wayenbergh R. , Taelman V. , Pichon B. , Fischer A. , Kricha S. , Gessler M. , Christophe D. , Bellefroid E.J.
Dev. Dyn.228:716-725(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCDC89
11.

"The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain."
Sakamoto M. , Hirata H. , Ohtsuka T. , Bessho Y. , Kageyama R.
J. Biol. Chem.278:44808-44815(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
12.

"The Notch target genes Hey1 and Hey2 are required for embryonic vascular development."
Fischer A. , Schumacher N. , Maier M. , Sendtner M. , Gessler M.
Genes Dev.18:901-911(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system."
Kokubo H. , Miyagawa-Tomita S. , Nakazawa M. , Saga Y. , Johnson R.L.
Dev. Biol.278:301-309(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts."
Fischer A. , Klattig J. , Kneitz B. , Diez H. , Maier M. , Holtmann B. , Englert C. , Gessler M.
Mol. Cell. Biol.25:8960-8970(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GATA4 AND GATA6
15.

"Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
Fischer A. , Steidl C. , Wagner T.U. , Lang E. , Jakob P.M. , Friedl P. , Knobeloch K.-P. , Gessler M.
Circ. Res.100:856-863(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HEYL;DEVELOPMENTAL STAGE
16.

"Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2."
Kokubo H. , Tomita-Miyagawa S. , Hamada Y. , Saga Y.
Development134:747-755(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE

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