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Index > Protein center > HEY2(Gene name) > Human
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  • HEY2 (Gene name),
  • Hairy/enhancer-of-split related with YRPW motif protein 2 (Protein name ),  HEY2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    HEY2(BHLHB32;CHF1;GRL;HERP;HERP1;HRT2);
    Protein name:
    Hairy/enhancer-of-split related with YRPW motif protein 2;
    Alternative:
    Class B basic helix-loop-helix protein 32(bHLHb32);Cardiovascular helix-loop-helix factor 1(hCHF1);Hairy and enhancer of split-related protein 2(HESR-2);HES-related repressor protein 2;Protein gridlock homolog;Hairy-related transcription factor 2(HRT-2;hHRT2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.
    Function:
    Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    337
    Sequence:
    50:
    MKRPCEETTS | ESDMDETIDV | GSENNYSGQS | TSSVIRLNSP | TTTSQIMARK | 
    100:
    KRRGIIEKRR | RDRINNSLSE | LRRLVPTAFE | KQGSAKLEKA | EILQMTVDHL | 
    150:
    KMLQATGGKG | YFDAHALAMD | FMSIGFRECL | TEVARYLSSV | EGLDSSDPLR | 
    200:
    VRLVSHLSTC | ATQREAAAMT | SSMAHHHHPL | HPHHWAAAFH | HLPAALLQPN | 
    250:
    GLHASESTPC | RLSTTSEVPP | AHGSALLTAT | FAHADSALRM | PSTGSVAPCV | 
    300:
    PPLSTSLLSL | SATVHAAAAA | ATAAAHSFPL | SFAGAFPMLP | PNAAAAVAAA | 
    337:
    TAISPPLSVS | ATSSPQQTSS | GTNNKPYRPW | GTEVGAF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    Pfam:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    ELISA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    CLIA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    CLIA Kit for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    Polyclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    Polyclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    Monoclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    Monoclonal Antibody for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    Protein for Human Hairy/enhancer-of-split related with YRPW motif protein 2
    Protein for Human Hairy/enhancer-of-split related with YRPW motif protein 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
      Leimeister C. , Externbrinck A. , Klamt B. , Gessler M.
      Mech. Dev.85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Gridlock, an HLH gene required for assembly of the aorta in zebrafish."
      Zhong T.P. , Rosenberg M. , Mohideen M.-A.P.K. , Weinstein B. , Fishman M.C.
      Science287:1820-1824(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Heart.
    3. 3.
      "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
      Chin M.T. , Maemura K. , Fukumoto S. , Jain M.K. , Layne M.D. , Watanabe M. , Hsieh C.-M. , Lee M.-E.
      J. Biol. Chem.275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH ARNT
      tissue: Heart.
    4. 4.
      "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
      Nakagawa O. , McFadden D.G. , Nakagawa M. , Yanagisawa H. , Hu T. , Srivastava D. , Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A.97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DNA-BINDING
    5. 5.
      "HERP, a new primary target of Notch regulated by ligand binding."
      Iso T. , Sartorelli V. , Chung G. , Shichinohe T. , Kedes L. , Hamamori Y.
      Mol. Cell. Biol.21:6071-6079(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Heart.
    6. 6.
      "Homo sapiens testis cDNA clone, basic-helix-loop-helix protein (Hey2)."
      Tanaka K. , Miyata J. , Ikeda J.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Testis.
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    10. 10.
      "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
      Kathiriya I.S. , King I.N. , Murakami M. , Nakagawa M. , Astle J.M. , Gardner K.A. , Gerard R.D. , Olson E.N. , Srivastava D. , Nakagawa O.
      J. Biol. Chem.279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6."
      Shirvani S. , Xiang F. , Koibuchi N. , Chin M.T.
      Biochem. Biophys. Res. Commun.339:151-156(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GATA6;MUTAGENESIS OF GLY-54
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-96; ALA-98 AND SER-100
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