Hey2 ELISA Kit for Mouse(Mus musculus) | EIAab.comHey2 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Hey2 (Gene name),

Hairy/enhancer-of-split related with YRPW motif protein 2 (Protein name ), HEY2_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

Hey2(Chf1;Herp;Herp1;Hesr2;Hrt2);

Protein name:

Hairy/enhancer-of-split related with YRPW motif protein 2;

Alternative:

Hairy and enhancer of split-related protein 2(HESR-2);HES-related repressor protein 2;Protein gridlock homolog;Hairy-related transcription factor 2(HRT-2;mHRT2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

May self-associate (By similarity). Interacts with ARNT (By similarity). Interacts with GATA4, GATA6, HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A.

Function:

Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

339

Sequence:

50:

MKRPCEETTS | ESDLDETIDV | GSENNYPGHA | TSSVMRSNSP | TTTSQIMARK |

100:

KRRGIIEKRR | RDRINNSLSE | LRRLVPTAFE | KQGSAKLEKA | EILQMTVDHL |

150:

KMLQATGGKG | YFDAHALATD | FMSIGFRECL | TEVARYLSSV | EGLDPSDPLR |

200:

VRLVSHLSTC | ASQREAAVMT | SSMAHHHHPL | HPHHWAAAFH | HLPTALLQPN |

250:

GLHTSESTPC | RLSTSSEVPS | AHGSALLTAT | FAHADSALRM | PSGGTVAPCV |

300:

PPLSTSLLSL | SATVHAAAAA | ATAAAHSFPL | SFAGAFPMLP | SNAAAAAAVA |

339:

AATAISPPLS | VSAASSPQQT | STGTNNKPYQ | PWGTEVGAF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

SMR:

Pfam:

KEGG:

String:

Uniprot:

FOR

ELISA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

ELISA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

CLIA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

CLIA Kit for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

Polyclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

Polyclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

Monoclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

Monoclonal Antibody for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

Protein for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

Protein for Mouse Hairy/enhancer-of-split related with YRPW motif protein 2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"HRT1, HRT2 and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments."
Nakagawa O. , Nakagawa M. , Richardson J.A. , Olson E.N. , Srivastava D.
Dev. Biol.216:72-84(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
2.

"Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
Steidl C. , Leimeister C. , Klamt B. , Maier M. , Nanda I. , Dixon M. , Clarke R. , Schmid M. , Gessler M.
Genomics66:195-203(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
3.

"Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
Chin M.T. , Maemura K. , Fukumoto S. , Jain M.K. , Layne M.D. , Watanabe M. , Hsieh C.-M. , Lee M.-E.
J. Biol. Chem.275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
4.

"HERP, a new primary target of Notch regulated by ligand binding."
Iso T. , Sartorelli V. , Chung G. , Shichinohe T. , Kedes L. , Hamamori Y.
Mol. Cell. Biol.21:6071-6079(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Cloning of hesr2 gene."
Kokubo H. , Johnson R.L.
Submitted (2002-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Inner ear.
tissue: Testis.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
8.

"Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
Leimeister C. , Externbrinck A. , Klamt B. , Gessler M.
Mech. Dev.85:173-177(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
9.

"Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes."
Maier M.M. , Gessler M.
Biochem. Biophys. Res. Commun.275:652-660(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
10.

"Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
Nakagawa O. , McFadden D.G. , Nakagawa M. , Yanagisawa H. , Hu T. , Srivastava D. , Olson E.N.
Proc. Natl. Acad. Sci. U.S.A.97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INDUCTION;MUTAGENESIS OF 49-ARG--ARG-61
11.

"The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina."
Satow T. , Bae S.-K. , Inoue T. , Inoue C. , Miyoshi G. , Tomita K. , Bessho Y. , Hashimoto N. , Kageyama R.
J. Neurosci.21:1265-1273(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
12.

"HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling."
Iso T. , Sartorelli V. , Poizat C. , Iezzi S. , Wu H.-Y. , Chung G. , Kedes L. , Hamamori Y.
Mol. Cell. Biol.21:6080-6089(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH HDAC1; HES1; NCOR1 AND SIN3A
13.

"Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice."
Gessler M. , Knobeloch K.-P. , Helisch A. , Amann K. , Schumacher N. , Rohde E. , Fischer A. , Leimeister C.
Curr. Biol.12:1601-1604(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
14.

"Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice."
Donovan J. , Kordylewska A. , Jan Y.N. , Utset M.F.
Curr. Biol.12:1605-1610(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
15.

"HERP1 is a cell type-specific primary target of Notch."
Iso T. , Chung G. , Hamamori Y. , Kedes L.
J. Biol. Chem.277:6598-6607(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION
16.

"Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2."
Sakata Y. , Kamei C.N. , Nakagami H. , Bronson R. , Liao J.K. , Chin M.T.
Proc. Natl. Acad. Sci. U.S.A.99:16197-16202(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
17.

"The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain."
Sakamoto M. , Hirata H. , Ohtsuka T. , Bessho Y. , Kageyama R.
J. Biol. Chem.278:44808-44815(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
18.

"Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro."
Sakata Y. , Xiang F. , Chen Z. , Kiriyama Y. , Kamei C.N. , Simon D.I. , Chin M.T.
Arterioscler. Thromb. Vasc. Biol.24:2069-2074(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction."
Kokubo H. , Miyagawa-Tomita S. , Tomimatsu H. , Nakashima Y. , Nakazawa M. , Saga Y. , Johnson R.L.
Circ. Res.95:540-547(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
20.

"The Notch target genes Hey1 and Hey2 are required for embryonic vascular development."
Fischer A. , Schumacher N. , Maier M. , Sendtner M. , Gessler M.
Genes Dev.18:901-911(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
Kathiriya I.S. , King I.N. , Murakami M. , Nakagawa M. , Astle J.M. , Gardner K.A. , Gerard R.D. , Olson E.N. , Srivastava D. , Nakagawa O.
J. Biol. Chem.279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GATA4;MUTAGENESIS OF 33-SER--SER-37
22.

"Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system."
Kokubo H. , Miyagawa-Tomita S. , Nakazawa M. , Saga Y. , Johnson R.L.
Dev. Biol.278:301-309(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts."
Fischer A. , Klattig J. , Kneitz B. , Diez H. , Maier M. , Holtmann B. , Englert C. , Gessler M.
Mol. Cell. Biol.25:8960-8970(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GATA4 AND GATA6;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
24.

"CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression."
Koibuchi N. , Chin M.T.
Circ. Res.100:850-855(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
25.

"Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
Fischer A. , Steidl C. , Wagner T.U. , Lang E. , Jakob P.M. , Friedl P. , Knobeloch K.-P. , Gessler M.
Circ. Res.100:856-863(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HEYL;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
26.

"Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2."
Kokubo H. , Tomita-Miyagawa S. , Hamada Y. , Saga Y.
Development134:747-755(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE

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