Heparan-alpha-glucosaminide N-acetyltransferase (Protein name
), HGNAT_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
HGSNAT(TMEM76);
Protein name:
Heparan-alpha-glucosaminide N-acetyltransferase;
Alternative:
Transmembrane protein 76;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homooligomer. Homooligomerization is necessary for enzyme activity.
Function:
Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
Subcellular Location:
Lysosome membrane
Multi-pass membrane protein
Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain.
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-663 (ISOFORMS 1/2)
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Cited for: INVOLVEMENT IN MPS3C;FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142
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Cited for: FUNCTION;ACTIVE SITE;ALTERNATIVE INITIATION (ISOFORMS 1 AND 2);SUBUNIT;CHARACTERIZATION OF VARIANT PHE-104;MUTAGENESIS OF CYS-107; CYS-151; CYS-179; LEU-236; ILE-237; HIS-297; CYS-333; CYS-402; CYS-462; HIS-479 AND HIS-633;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: VARIANTS MPS3C PHE-104; LEU-311; CYS-372; HIS-372; CYS-431; SER-452; LYS-499; LYS-510; LEU-569; VAL-590 AND LEU-599;VARIANTS GLN-265; GLN-551 AND THR-643;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: VARIANTS MPS3C PRO-165 AND PHE-546;VARIANT GLN-265
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Cited for: VARIANTS MPS3C PRO-165; ARG-280; LYS-301; CYS-372; LYS-499; PHE-546 AND CYS-567;VARIANT GLN-265
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Cited for: VARIANTS MPS3C PRO-165; LEU-311; CYS-372; CYS-431; LYS-499; GLU-514; GLU-517; PHE-546 AND LEU-569;VARIANTS GLN-265; LEU-509; GLN-551 AND THR-643;CHARACTERIZATION OF VARIANT MPS3C CYS-431;CHARACTERIZATION OF VARIANTS GLN-265; LEU-509; GLN-551 AND THR-643
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Cited for: CHARACTERIZATION OF VARIANTS MPS3C PHE-104; PRO-165; ARG-290; LEU-311; CYS-372; CYS-431; SER-452; LYS-499; LYS-510; GLU-514; GLU-517; PHE-546; CYS-567; LEU-569; VAL-590 AND LEU-599;CHARACTERIZATION OF VARIANTS GLN-265; LEU-509; GLN-551 AND THR-643
Vaild Sequence:
