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Index > Protein center > Hmgcr(Gene name) > Rat
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  • Hmgcr (Gene name),
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Protein name ),  HMDH_RAT from NCBI database.
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  • Gene name:
    Hmgcr;
    Protein name:
    3-hydroxy-3-methylglutaryl-coenzyme A reductase(HMG-CoA reductase);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    887
    Sequence:
    50:
    MLSRLFRMHG | LFVASHPWEV | IVGTVTLTIC | MMSMNMFTGN | NKICGWNYEC | 
    100:
    PKFEEDVLSS | DIIILTITRC | IAILYIYFQF | QNLRQLGSKY | ILGIAGLFTI | 
    150:
    FSSFVFSTVV | IHFLDKELTG | LNEALPFFLL | LIDLSRASAL | AKFALSSNSQ | 
    200:
    DEVRENIARG | MAILGPTFTL | DALVECLVIG | VGTMSGVRQL | EIMCCFGCMS | 
    250:
    VLANYFVFMT | FFPACVSLVL | ELSRESREGR | PIWQLSHFAR | VLEEEENKPN | 
    300:
    PVTQRVKMIM | SLGLVLVHAH | SRWIADPSPQ | NSTAEQSKVS | LGLAEDVSKR | 
    350:
    IEPSVSLWQF | YLSKMISMDI | EQVITLSLAL | LLAVKYIFFE | QAETESTLSL | 
    400:
    KNPITSPVVT | PKKAQDNCCR | REPLLVRRNQ | KLSSVEEDPG | VNQDRKVEVI | 
    450:
    KPLVAEAETS | GRATFVLGAS | AASPPLALGA | QEPGIELPSE | PRPNEECLQI | 
    500:
    LESAEKGAKF | LSDAEIIQLV | NAKHIPAYKL | ETLMETHERG | VSIRRQLLSA | 
    550:
    KLAEPSSLQY | LPYRDYNYSL | VMGACCENVI | GYMPIPVGVA | GPLCLDGKEY | 
    600:
    QVPMATTEGC | LVASTNRGCR | AISLGGGASS | RVLADGMSRG | PVVRLPRACD | 
    650:
    SAEVKSWLET | PEGFAVVKEA | FDSTSRFARL | QKLHVTLAGR | NLYIRLQSKT | 
    700:
    GDAMGMNMIS | KGTEKALLKL | QEFFPELQIL | AVSGNYCTDK | KPAAINWIEG | 
    750:
    RGKTVVCEAV | IPAKVVREVL | KTTTEAMVDV | NINKNLVGSA | MAGSIGGYNA | 
    800:
    HAANIVTAIY | IACGQDAAQN | VGSSNCITLM | EASGPTNEDL | YISCTMPSIE | 
    850:
    IGTVGGGTNL | LPQQACLQML | GVQGACKDNP | GENARQLARI | VCGTVMAGEL | 
    887:
    SLMAALAAGH | LVRSHMVHNR | SKINLQDLQG | TCTKKAA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat HMG-CoA reductase
    Cat.:
    E10451h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat HMG-CoA reductase
    Cat.:
    E10451r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat HMG-CoA reductase
    MSDS:
    Please sign in first.
    ELISA Kit for Rat HMG-CoA reductase
    MSDS:
    Please sign in first.
    ELISA Kit for Rat HMG-CoA reductase
    Cat.:
    E10451m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat HMG-CoA reductase
    MSDS:
    Please sign in first.
    CLIA Kit for Rat HMG-CoA reductase
    MSDS:
    Please sign in first.
    CLIA Kit for Rat HMG-CoA reductase
    MSDS:
    Please sign in first.
    CLIA Kit for Rat HMG-CoA reductase
    MSDS:
    Please sign in first.
    CLIA Kit for Rat HMG-CoA reductase
    Cat.:
    U10451r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat HMG-CoA reductase
    Cat.:
    U10451h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat HMG-CoA reductase
    Cat.:
    U10451m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat HMG-CoA reductase
    Cat.:
    P10451Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat HMG-CoA reductase
    Polyclonal Antibody for Rat HMG-CoA reductase
    Polyclonal Antibody for Rat HMG-CoA reductase
    Polyclonal Antibody for Rat HMG-CoA reductase
    Polyclonal Antibody for Rat HMG-CoA reductase
    Monoclonal Antibody for Rat HMG-CoA reductase
    Monoclonal Antibody for Rat HMG-CoA reductase
    Monoclonal Antibody for Rat HMG-CoA reductase
    Monoclonal Antibody for Rat HMG-CoA reductase
    Monoclonal Antibody for Rat HMG-CoA reductase
    Monoclonal Antibody for Rat HMG-CoA reductase
    Protein for Rat HMG-CoA reductase
    Protein for Rat HMG-CoA reductase
    Protein for Rat HMG-CoA reductase
    Protein for Rat HMG-CoA reductase
    Protein for Rat HMG-CoA reductase
    Protein for Rat HMG-CoA reductase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequencing of rat 3-hydroxy-3-methylglutaryl coenzyme A reductase."
      Hangjiong C. , Williams D. , Shapiro D.
      Submitted (1994-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    3. 3.
      "Rat HMG-CoA reductase cDNA sequence contains an unusual 36 bp insert bounded by inverted repeats."
      Khan S. , Kabat S. , Stambrook P.
      Submitted (1990-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 644-887
      strain: Sprague-Dawley.
      tissue: Liver.
    4. 4.
      "Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver."
      Clarke P.R. , Hardie D.G.
      EMBO J.9:2439-2446(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 423-443 AND 867-878;PHOSPHORYLATION AT SER-871
      tissue: Liver.
    5. 5.
      "Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation."
      Edwards P.A. , Kempner E.S. , Lan S.-F. , Erickson S.K.
      J. Biol. Chem.260:10278-10282(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
      tissue: Liver.
    6. 6.
      "Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes."
      Gillespie J.G. , Hardie D.G.
      FEBS Lett.306:59-62(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
      tissue: Liver.
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