MR1 ELISA Kit for Bovine(Bos taurus) | EIAab.comMR1 ELISA Kit for Bovine(Bos taurus)

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MR1 (Gene name),

Major histocompatibility complex class I-related gene protein (Protein name ), HMR1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MR1;

Protein name:

Major histocompatibility complex class I-related gene protein(MHC class I-related gene protein);

Alternative:

Class I histocompatibility antigen-like protein;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3.

Function:

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites (By similarity). Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Extracellular side Endoplasmic reticulum

Protein Attributes:

Sequence length:

336

Sequence:

50:

100:

150:

200:

250:

300:

336:

VGFIVLAIAL | AGVGILAWRK | RPRGKNKVIC | LSTPEH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07654

UniGene:

Bt.63045

KEGG:

bta:506206

Uniprot:

C1ITJ8

FOR

ELISA Kit for Bovine MHC class I-related gene protein

CLIA Kit for Bovine MHC class I-related gene protein

Polyclonal Antibody for Bovine MHC class I-related gene protein

Monoclonal Antibody for Bovine MHC class I-related gene protein

Protein for Bovine MHC class I-related gene protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution."
Huang S. , Martin E. , Kim S. , Yu L. , Soudais C. , Fremont D.H. , Lantz O. , Hansen T.H.
Proc. Natl. Acad. Sci. U.S.A.106:8290-8295(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBUNIT
2.

"Ruminant MR1 and MAIT cells."
Van Rhijn I.
Submitted (2008-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V. , Delcher A.L. , Florea L. , Kelley D.R. , Schatz M.C. , Puiu D. , Hanrahan F. , Pertea G. , Van Tassell C.P. , Sonstegard T.S. , Marcais G. , Roberts M. , Subramanian P. , Yorke J.A. , Salzberg S.L.
Genome Biol.10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Hereford.
4.

"The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins."
Lopez-Sagaseta J. , Dulberger C.L. , Crooks J.E. , Parks C.D. , Luoma A.M. , McFedries A. , Van Rhijn I. , Saghatelian A. , Adams E.J.
Proc. Natl. Acad. Sci. U.S.A.110:E1771-E1778(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 19-295 IN COMPLEX WITH B2M AND HUMAN T-CELL RECEPTOR;DISULFIDE BONDS

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