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Index > Protein center > Mr1(Gene name) > Mouse
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  • Mr1 (Gene name),
  • Major histocompatibility complex class I-related gene protein (Protein name ),  HMR1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mr1(Mr1a);
    Protein name:
    Major histocompatibility complex class I-related gene protein(MHC class I-related gene protein);
    Alternative:
    Class I histocompatibility antigen-like protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3.
    Function:
    Has antigen presentation function. Involved in the development and expansion of a small population of T cells expressing an invariant T cell receptor alpha chain called mucosal-associated invariant T cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therfore may be involed in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
    Subcellular Location:
    Membrane Single-pass membrane protein Endoplasmic reticulum
    Protein Attributes:
    Sequence length:
    341
    Sequence:
    50:
    MMLLLPLLAV | FLVKRSHTRT | HSLRYFRLAV | SDPGPVVPEF | ISVGYVDSHP | 
    100:
    ITTYDSVTRQ | KEPKAPWMAE | NLAPDHWERY | TQLLRGWQQT | FKAELRHLQR | 
    150:
    HYNHSGLHTY | QRMIGCELLE | DGSTTGFLQY | AYDGQDFIIF | NKDTLSWLAM | 
    200:
    DYVAHITKQA | WEANLHELQY | QKNWLEEECI | AWLKRFLEYG | RDTLERTEHP | 
    250:
    VVRTTRKETF | PGITTFFCRA | HGFYPPEISM | TWMKNGEEIA | QEVDYGGVLP | 
    300:
    SGDGTYQTWL | SVNLDPQSND | VYSCHVEHCG | RQMVLEAPRE | SGDILRVSTI | 
    341:
    SGTTILIIAL | AGVGVLIWRR | SQELKEVMYQ | PTQVNEGSSP | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MHC class I-related gene protein
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    E0910h
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    Packing:
    96T
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    ELISA Kit for Mouse MHC class I-related gene protein
    Cat.:
    E0910m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse MHC class I-related gene protein
    Cat.:
    E0910r
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    96T
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    ELISA Kit for Mouse MHC class I-related gene protein
    Cat.:
    E0910b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MHC class I-related gene protein
    Cat.:
    U0910h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MHC class I-related gene protein
    Cat.:
    U0910b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MHC class I-related gene protein
    Cat.:
    U0910r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MHC class I-related gene protein
    Cat.:
    U0910m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse MHC class I-related gene protein
    Polyclonal Antibody for Mouse MHC class I-related gene protein
    Cat.:
    P0910Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MHC class I-related gene protein
    Cat.:
    P0910Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MHC class I-related gene protein
    Cat.:
    P0910Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MHC class I-related gene protein
    Monoclonal Antibody for Mouse MHC class I-related gene protein
    Monoclonal Antibody for Mouse MHC class I-related gene protein
    Monoclonal Antibody for Mouse MHC class I-related gene protein
    Protein for Mouse MHC class I-related gene protein
    Protein for Mouse MHC class I-related gene protein
    Protein for Mouse MHC class I-related gene protein
    Protein for Mouse MHC class I-related gene protein

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    References
    1. 1.
      "A highly conserved major histocompatibility complex class I-related gene in mammals."
      Yamaguchi H. , Hirai M. , Kurosawa Y. , Hashimoto K.
      Biochem. Biophys. Res. Commun.238:697-702(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      strain: BALB/c.
      tissue: Lung.
    2. 2.
      "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene."
      Riegert P. , Wanner V. , Bahram S.
      J. Immunol.161:4066-4077(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
      strain: C57BL/6.
      strain: C57BL/6J X 129/SvJ.
      tissue: Spleen.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: Czech II.
      tissue: Mammary tumor.
    5. 5.
      "Association of MR1 protein, an MHC class I-related molecule, with beta(2)-microglobulin."
      Yamaguchi H. , Hashimoto K.
      Biochem. Biophys. Res. Commun.290:722-729(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH B2M
    6. 6.
      "Biochemical features of the MHC-related protein 1 consistent with an immunological function."
      Miley M.J. , Truscott S.M. , Yu Y.Y. , Gilfillan S. , Fremont D.H. , Hansen T.H. , Lybarger L.
      J. Immunol.170:6090-6098(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH B2M; TAPBP; CALR AND PDIA3;MUTAGENESIS OF CYS-279
    7. 7.
      "Evidence for MR1 antigen presentation to mucosal-associated invariant T cells."
      Huang S. , Gilfillan S. , Cella M. , Miley M.J. , Lantz O. , Lybarger L. , Fremont D.H. , Hansen T.H.
      J. Biol. Chem.280:21183-21193(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-25; ARG-27; PHE-40; LEU-83; GLY-86; LYS-92; ALA-93; GLN-99; TYR-110; ARG-112; LEU-128; TYR-170 AND ALA-181
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